Create a routing handler like this: Handlers.routing()     .add(Methods.GET, "/*", exchange -> "domain1".equals(exchange.getHostName()), handler1)     .add(Methods.GET, "/{value1}/{value2}", exchange -> "domain2".equals(exchange.getHostName()), handler2); The handler2 will never be used. Even if the request is on domain2, and the URI matches }}{{"/{value1}/{value2}", it will still only try the "/*" template, and then use the fallback handler when the predicate doesn't match. It appears that this is because PathTemplateMatcher::trimBase() returns "/" (with a trailing slash) for the  "/*" {{ template, whereas it returns "" (without a trailing slash) for the }} "/{value1}/{value2}" template , and the longest matching prefix {{ is used}}{{ (and "/" will always win over "").}} This will happen even if I set the predicate for "/*" to always return false: Handlers.routing()     .add(Methods.GET, "/*", exchange -> false, handler1)     .add(Methods.GET, "/{value1}/{value2}", exchange -> true, handler2);