[root@dell-per750-34 ~]# uname -r
5.14.0-564.el9.x86_64 
[root@dell-per750-34 ~]# yum install -y tuned tuned-profiles-realtime tuned-profiles-nfv tuned-profiles-cpu-partitioning

[root@dell-per750-34 ~]#  cat /etc/tuned/performance/tuned.conf 
[main]
summary=Customize Performance TuneD profile
include=cpu-partitioning[variables]
isolated_cores=2,34,3,35,4,36,5,37,6,38,7,39,8,40,9,41,10,42,11,43,12,44,13,45,14,46,15,47,16,48,17,49,18,50,19,51,20,52,21,53,22,54,23,55,24,56,25,57,26,58,27,59,28,60,29,61,30,62,31,63
not_isolated_cores_expanded="${f:cpulist_invert:${isolated_cores_expanded}}"[cpu]
force_latency=cstate.id:1|3
governor=performance
energy_perf_bias=performance
min_perf_pct=100[bootloader]
initrd_remove_dir=
initrd_dst_img=
initrd_add_dir=
cmdline_cpu_part=+nohz=on rcu_nocbs="${isolated_cpu}" tuned.non_isolcpus="${not_isolated_cpumask}" intel_pstate=disable nosoftlockup
cmdline_realtime=+tsc=nowatchdog intel_iommu=on iommu=pt isolcpus=managed_irq,"${isolated_cpu}" systemd.cpu_affinity="${not_isolated_cores_expanded}"
cmdline_additionalArg=+ audit=0 idle=poll intel_idle.max_cstate=0 mce=off nmi_watchdog=0 processor.max_cstate=1

[root@dell-per750-34 ~]# cat /etc/sysconfig/irqbalance | grep IRQBALANCE_BANNED_CPULIST   
# IRQBALANCE_BANNED_CPULIST
#IRQBALANCE_BANNED_CPULIST=

[root@dell-per750-34 ~]# systemctl start tuned
[root@dell-per750-34 ~]# systemctl status tuned
○ tuned.service - Dynamic System Tuning Daemon
     Loaded: loaded (/usr/lib/systemd/system/tuned.service; enabled; preset: enabled)
     Active: inactive (dead) since Mon 2025-02-10 00:28:31 EST; 10s ago
       Docs: man:tuned(8)
             man:tuned.conf(5)
             man:tuned-adm(8)
    Process: 2731 ExecStart=/usr/sbin/tuned -l -P (code=exited, status=0/SUCCESS)
   Main PID: 2731 (code=exited, status=0/SUCCESS)
        CPU: 813msFeb 10 00:28:30 dell-per750-34.rhts.eng.pek2.redhat.com systemd[1]: Starting Dynamic System Tuning Daemon...
Feb 10 00:28:31 dell-per750-34.rhts.eng.pek2.redhat.com systemd[1]: tuned.service: Deactivated successfully.
Feb 10 00:28:31 dell-per750-34.rhts.eng.pek2.redhat.com systemd[1]: Started Dynamic System Tuning Daemon.
[root@dell-per750-34 ~]# tuned-adm profile performance 
Trying to (re)start tuned...
TuneD (re)started.
TuneD is not active on the DBus, not checking whether the profile was successfully applied.
[root@dell-per750-34 ~]# tuned-adm list   
Available profiles:
- accelerator-performance     - Throughput performance based tuning with disabled higher latency STOP states
- aws                         - Optimize for aws ec2 instances
- balanced                    - General non-specialized tuned profile
- balanced-battery            - Balanced profile biased towards power savings changes for battery
- cpu-partitioning            - Optimize for CPU partitioning
- cpu-partitioning-powersave  - Optimize for CPU partitioning with additional powersave
- desktop                     - Optimize for the desktop use-case
- hpc-compute                 - Optimize for HPC compute workloads
- intel-sst                   - Configure for Intel Speed Select Base Frequency
- latency-performance         - Optimize for deterministic performance at the cost of increased power consumption
- network-latency             - Optimize for deterministic performance at the cost of increased power consumption, focused on low latency network performance
- network-throughput          - Optimize for streaming network throughput, generally only necessary on older CPUs or 40G+ networks
- optimize-serial-console     - Optimize for serial console use.
- performance                 - Customize Performance TuneD profile
- powersave                   - Optimize for low power consumption
- realtime                    - Optimize for realtime workloads
- realtime-virtual-guest      - Optimize for realtime workloads running within a KVM guest
- realtime-virtual-host       - Optimize for KVM guests running realtime workloads
- throughput-performance      - Broadly applicable tuning that provides excellent performance across a variety of common server workloads
- virtual-guest               - Optimize for running inside a virtual guest
- virtual-host                - Optimize for running KVM guests
It seems that tuned daemon is not running, preset profile is not activated. 

[root@dell-per750-34 ~]# cat /etc/sysconfig/irqbalance | grep IRQBALANCE_BANNED_CPULIST   
# IRQBALANCE_BANNED_CPULIST
#IRQBALANCE_BANNED_CPULIST=