When using GnuPG (gpg) with Yubikey it asks for password for each single operation. Prior RHEL releases could cache the password for a certain time (configurable via ~/.gnupg/gpg-agent.conf).
This is no longer possible to control, making this a huge hurdle in daily life when doing a lot of PGP related operations.
Some research claims this is related to OpenSC and the pcscd service used by GnuPG.