We have an open case with Akamai (https://control.akamai.com/apps/case-management/#/cases/F-CS-9460253/view) about timeouts related to large files being downloaded on slow networks. The presigned URL we use to authenticate Akamai and S3 expires after 10 minutes. If the user has not been able to download the file in that time, Akamai is unable to complete the request. This is because of how Akamai does range requests. The current proposed solution is for Akamai to front run the request and seed CloudWrapper with the data using their fast connection to S3. If that does not work, we will need to update quay.io to store all large files on CloudFront.