Test scenario assumes autocreate is turned on.

1. Subscribe consumer to queue X on broker1 (Master1)

   java  -jar /var/dtests/node_data/clients/acce.jar receiver --log-msgs dict --broker 10.37.145.211:61616 --conn-username admin --conn-password admin --address lalaQ --count 100 --timeout 500
   

2. Send message to queue X on broker1 - passes

   java  -jar /var/dtests/node_data/clients/acce.jar sender --timeout 120 --log-msgs dict --broker 10.37.145.211:61616 --conn-username admin --conn-password admin --address lalaQ --count 1
   

3. Send message to queue X on broker2 - failure

   java  -jar /var/dtests/node_data/clients/acce.jar sender --timeout 120 --log-msgs dict --broker 10.37.145.217:61616 --conn-username admin --conn-password admin --address lalaQ --count 1
   16:36:44,932 ERROR ActiveMQInternalErrorException[errorType=INTERNAL_ERROR message=null]
   16:36:44,935 ERROR Error while sending a message!
   javax.jms.JMSException
   	at org.apache.activemq.artemis.core.protocol.core.impl.ChannelImpl.sendBlocking(ChannelImpl.java:423)
   	at org.apache.activemq.artemis.core.protocol.core.impl.ChannelImpl.sendBlocking(ChannelImpl.java:319)
   	at org.apache.activemq.artemis.core.protocol.core.impl.ActiveMQSessionContext.sendFullMessage(ActiveMQSessionContext.java:479)
   	at org.apache.activemq.artemis.core.client.impl.ClientProducerImpl.sendRegularMessage(ClientProducerImpl.java:304)
   	at org.apache.activemq.artemis.core.client.impl.ClientProducerImpl.doSend(ClientProducerImpl.java:276)
   	at org.apache.activemq.artemis.core.client.impl.ClientProducerImpl.send(ClientProducerImpl.java:129)
   	at org.apache.activemq.artemis.jms.client.ActiveMQMessageProducer.doSendx(ActiveMQMessageProducer.java:517)
   	at org.apache.activemq.artemis.jms.client.ActiveMQMessageProducer.send(ActiveMQMessageProducer.java:192)
   	at com.redhat.mqe.acc.AccSenderClient.startClient(AccSenderClient.java:99)
   	at com.redhat.mqe.lib.Main.main(Main.java:46)
   	at com.redhat.mqe.acc.Main.main(Main.java:85)
   	at com.redhat.mqe.acc.Main.main(Main.java:89)
   Caused by: ActiveMQInternalErrorException[errorType=INTERNAL_ERROR message=null]
   	... 12 more
   

4. Disconnect subscribed consumer from broker1
5. Try previous step again (send message to X on broker2) - passes

I was able to reproduce this with the latest 7.2.2 broker provided yesterday.
This seems like a weird "locking mechanism" only when message-load-balancing is set to OFF.

You can download clients from here:
http://messaging-qe-repo.usersys.redhat.com:8081/artifactory/cli-java/

aac1.jar = cli-qpid-jms-1.2.2-SNAPSHOT-0.37.0.redhat-00001.jar AMQP
acce.jar = cli-artemis-jms-1.2.2-SNAPSHOT-2.6.3.redhat-00004.jar Core
aoc7.jar = cli-activemq-1.2.2-SNAPSHOT-5.11.0.redhat-630329.jar Openwire

Openwire & AMQP broker log exceptions only provide:

2018-10-16 16:53:42,666 WARN  [org.apache.activemq.artemis.core.client] AMQ212037: Connection failure has been detected: null [code=GENERIC_EXCEPTION]
2018-10-16 16:53:42,668 WARN  [org.apache.activemq.artemis.core.server] AMQ222061: Client connection failed, clearing up resources for session 46350252-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:42,668 WARN  [org.apache.activemq.artemis.core.server] AMQ222107: Cleared up resources for session 46350252-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:42,669 WARN  [org.apache.activemq.artemis.core.server] AMQ222061: Client connection failed, clearing up resources for session 463884c3-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:42,669 WARN  [org.apache.activemq.artemis.core.server] AMQ222107: Cleared up resources for session 463884c3-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:57,360 WARN  [org.apache.activemq.artemis.core.client] AMQ212037: Connection failure has been detected: null [code=GENERIC_EXCEPTION]
2018-10-16 16:53:57,363 WARN  [org.apache.activemq.artemis.core.server] AMQ222061: Client connection failed, clearing up resources for session 4efe75b4-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:57,363 WARN  [org.apache.activemq.artemis.core.server] AMQ222107: Cleared up resources for session 4efe75b4-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:57,364 WARN  [org.apache.activemq.artemis.core.server] AMQ222061: Client connection failed, clearing up resources for session 4f03cce5-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:53:57,364 WARN  [org.apache.activemq.artemis.core.server] AMQ222107: Cleared up resources for session 4f03cce5-d153-11e8-86f0-5254001fbc3f
2018-10-16 16:54:11,047 WARN  [org.apache.activemq.artemis.core.client] AMQ212037: Connection failure has been detected: null [code=GENERIC_EXCEPTION]