I have attached a test route reproducer-context.xml to reproduce the issue. The route reads from an activemq queue and uses cxf to send it to an http endpoint. The destination http endpoint does not exist and this is the expected configuration for reproducing the issue, Note: make sure fuse is configured with async http client so that cxf can use it. install cxf-http-async feature. Once test route is deployed, post the test-input.xml to the queue multiple times. You can use the Producer.java to send messages. Monitor the logs coming from the route, once the logs stop. do the route-info in fuse console and try to restart the bundle containing the blueprint, you will see inflight exchanges reported.