The problem can easily be demonstrated using a piece of code like that attached. In this example, 192.168.1.114 is the IP number of the machine running the route, and therefore not reachable through the proxy. Using "localhost" here probably won't prove anything, because the JVMs stock HTTP client excludes localhost and its variants from proxying by default, and the HTTP client used by Camel might do the same (for all I know). Looking at the network traffic using tcpdump, I see HTTP requests for 192.168.1.114 being sent to the proxy, indicating that nonProxyHosts is not working. <?xml version= "1.0" encoding= "UTF-8" ?> <beans xmlns= "http: //www.springframework.org/schema/beans" xmlns:xsi= "http: //www.w3.org/2001/XMLSchema-instance" xmlns:osgix= "http: //www.springframework.org/schema/osgi-compendium" xmlns:cxf= "http: //camel.apache.org/schema/cxf" xmlns:cxfcore= "http: //cxf.apache.org/core" xmlns:osgi= "http: //www.springframework.org/schema/osgi" xsi:schemaLocation=" http: //www.springframework.org/schema/beans http://www.springframework.org/schema/beans/spring-beans-3.2.xsd http: //www.springframework.org/schema/osgi-compendium http://www.springframework.org/schema/osgi-compendium/spring-osgi-compendium-1.2.xsd http: //camel.apache.org/schema/spring http://camel.apache.org/schema/spring/camel-spring.xsd http: //camel.apache.org/schema/cxf http://camel.apache.org/schema/cxf/camel-cxf.xsd http: //cxf.apache.org/core http://cxf.apache.org/schemas/core.xsd "> <camelContext id= "XXX" xmlns= "http: //camel.apache.org/schema/spring" > <properties> <property key= "http.proxyHost" value= "squid.corp.redhat.com" /> <property key= "http.proxyPort" value= "3128" /> <property key= "http.nonProxyHosts" value= "192.168.1.114" /> </properties> <route> <from uri= "timer: //foo?period=1000&amp;fixedRate= true " /> <to uri= "http4: //192.168.1.114:8181/cxf/?proxyHost=squid.corp.redhat.com&amp;proxyPort2=3128" /> <to uri= "log: //foo" /> </route> </camelContext> </beans>