The current CentOS Stream 10 ISOs on the mirrors (CentOS-Stream-10-20250611.0, both boot and dvd) fail to boot. Looking back at previous composes, it seems that CentOS-Stream-10-20250603.0 and earlier boot fine, but CentOS-Stream-10-20250604.0 and later have this problem.

Reproducing this in a virtual machine in virt-manager results in the following error message:

Booting from Hard Disk...
Boot failed: not a bootable disk

No bootable device.

I was also able to reproduce the failure to boot on an Intel NUC (secure boot disabled), however the boot process stops and powers down the machine rather than displaying the above error message.