10540283
1999
12
17
1999
12
17
2006
11
15
0950-382X
34
1
1999
Oct
Molecular microbiology
Mol. Microbiol.
Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein.
24-36
The nirIX gene cluster of Paracoccus denitrificans is located between the nir and nor gene clusters encoding nitrite and nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is soluble and apparently located in the periplasm, as judged by the predicted signal sequence. NirI and NirX are homologues of NosR and NosX, proteins involved in regulation of the expression of the nos gene cluster encoding nitrous oxide reductase in Pseudomonas stutzeri and Sinorhizobium meliloti. Analysis of a NirI-deficient mutant strain revealed that NirI is involved in transcription activation of the nir gene cluster in response to oxygen limitation and the presence of N-oxides. The NirX-deficient mutant transiently accumulated nitrite in the growth medium, but it had a final growth yield similar to that of the wild type. Transcription of the nirIX gene cluster itself was controlled by NNR, a member of the family of FNR-like transcriptional activators. An NNR binding sequence is located in the middle of the intergenic region between the nirI and nirS genes with its centre located at position -41.5 relative to the transcription start sites of both genes. Attempts to complement the NirI mutation via cloning of the nirIX gene cluster on a broad-host-range vector were unsuccessful, the ability to express nitrite reductase being restored only when the nirIX gene cluster was reintegrated into the chromosome of the NirI-deficient mutant via homologous recombination in such a way that the wild-type nirI gene was present directly upstream of the nir operon.
Department of Molecular Cell Physiology, Faculty of Biology, BioCentrum Amsterdam, Vrije Universiteit, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands.
Saunders
N F
NF
Houben
E N
EN
Koefoed
S
S
de Weert
S
S
Reijnders
W N
WN
Westerhoff
H V
HV
De Boer
A P
AP
Van Spanning
R J
RJ
eng
GENBANK
AF005358
U47133
U94899
PDB
P33943
Journal Article
Research Support, Non-U.S. Gov't
ENGLAND
Mol Microbiol
8712028
0950-382X
0
Bacterial Proteins
0
DNA-Binding Proteins
0
Membrane Proteins
0
NNR protein, Paracoccus denitrificans
0
NirI protein, Paracoccus denitrificans
0
NirX protein, Paracoccus denitrificans
0
Transcription Factors
EC 1.7.-
Nitrite Reductases
IM
Amino Acid Sequence
Bacterial Proteins
Base Sequence
DNA-Binding Proteins
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Membrane Proteins
chemistry
genetics
metabolism
Molecular Sequence Data
Multigene Family
Mutation
Nitrite Reductases
genetics
metabolism
Paracoccus denitrificans
genetics
metabolism
Protein Structure, Secondary
Sequence Homology, Amino Acid
Transcription Factors
genetics
metabolism
Transcription, Genetic
10612833
2000
01
20
2000
01
20
2009
11
19
1098-1004
15
1
2000
Jan
Human mutation
Hum. Mutat.
Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans.
114-5
Usher syndromeIb (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult retinal pigment epithelium cells (ARPE-19) as a model system. A 160 bp minimal promoter within the first intron was active in ARPE-19 cells, but not in HeLa cells that do not express MYO7A. A 100 bp sequence, 5' of the first exon, and repeated with 90% homology within the first intron, appeared to modulate expression in both cell lines. Segments containing these elements were screened by heteroduplex analysis. No heteroduplexes were detected in the minimal promoter, suggesting that this sequence is conserved. A -2568 A>T transversion in the 5' 100 bp repeat, eliminating a CCAAT element, was found only in USH1B patients. However, in all 5 families, -2568 A>T was in cis with the same missense mutation in the myosin VIIa tail (Arg1240Gln), and 4 of the 5 families were Dutch. These observations suggest either 1) linkage disequilibrium or 2)that a combination of a promoter mutation with a less active myosin VIIa protein results in USH1B.
Copyright 2000 Wiley-Liss, Inc.
Center for Hereditary Communication Disorders, Boys Town National Research Hospital Omaha, NE, USA. ortend@boystown.org
Orten
D J
DJ
Weston
M D
MD
Kelley
P M
PM
Cremers
C W
CW
Wagenaar
M
M
Jacobson
S G
SG
Kimberling
W J
WJ
eng
DC00677
DC
NIDCD NIH HHS
United States
DC00982
DC
NIDCD NIH HHS
United States
DC03351
DC
NIDCD NIH HHS
United States
Corrected and Republished Article
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
UNITED STATES
Hum Mutat
9215429
1059-7794
EC 3.6.1.33
myosin VIIa
EC 3.6.4.1
Myosins
EC 3.6.4.2
Dyneins
IM
Hum Mutat. 1999 Oct;14(4):354
10502787
Amino Acid Substitution
Cell Line
Dyneins
Gene Expression Regulation
Hearing Loss, Sensorineural
genetics
metabolism
Hela Cells
Humans
Linkage Disequilibrium
Mutation, Missense
Myosins
biosynthesis
genetics
Pedigree
Pigment Epithelium of Eye
metabolism
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Promoter Regions, Genetic
Retinitis Pigmentosa
genetics
metabolism
Syndrome
Vestibular Diseases
genetics
metabolism
10737756
2000
04
13
2000
04
13
2004
11
17
0022-2623
43
6
2000
Mar
23
Journal of medicinal chemistry
J. Med. Chem.
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.
1234-41
The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-D-glucamine afforded 2-(S)-(1-(R)-(3, 5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-(2- phosphoryl-3-oxo-4H,-1,2,4-triazolo)methylmorpholine, bis(N-methyl-D-glucamine) salt, 11. Incubation of 11 in rat, dog, and human plasma and in human hepatic subcellular fractions in vitro indicated that conversion to 2 would be expected to occur in vivo most readily in humans during hepatic circulation. Conversion of 11 to 2 occurred rapidly in vivo in the rat and dog with the levels of 11 being undetectable within 5 min after 1 and 8 mg/kg doses iv in the rat and within 15 min after 0.5, 2, and 32 mg/kg doses iv in the dog. Compound 11 has a 10-fold lower affinity for the human NK-1 receptor as compared to 2, but it is functionally equivalent to 2 in preclinical models of NK-1-mediated inflammation in the guinea pig and cisplatin-induced emesis in the ferret, indicating that 11 acts as a prodrug of 2. Based in part on these data, 11 was identified as a novel, water-soluble prodrug of the clinical candidate 2 suitable for intravenous administration in humans.
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Merck, Sharp & Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K. jeffrey_hale@merck.com
Hale
J J
JJ
Mills
S G
SG
MacCoss
M
M
Dorn
C P
CP
Finke
P E
PE
Budhu
R J
RJ
Reamer
R A
RA
Huskey
S E
SE
Luffer-Atlas
D
D
Dean
B J
BJ
McGowan
E M
EM
Feeney
W P
WP
Chiu
S H
SH
Cascieri
M A
MA
Chicchi
G G
GG
Kurtz
M M
MM
Sadowski
S
S
Ber
E
E
Tattersall
F D
FD
Rupniak
N M
NM
Williams
A R
AR
Rycroft
W
W
Hargreaves
R
R
Metzger
J M
JM
MacIntyre
D E
DE
eng
Journal Article
UNITED STATES
J Med Chem
9716531
0022-2623
0
2-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro)phenyl-4-(5-(2-phosphoryl-3-oxo-4H,-1,2,4-triazolo))methylmorpholine, bis(N-methylglucamine) salt
0
Acetals
0
Anti-Inflammatory Agents, Non-Steroidal
0
Antiemetics
0
Antineoplastic Agents
0
L 754030
0
Morpholines
0
Prodrugs
0
Receptors, Neurokinin-1
15663-27-1
Cisplatin
7732-18-5
Water
IM
Acetals
chemical synthesis
chemistry
metabolism
pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal
chemical synthesis
chemistry
metabolism
pharmacology
Antiemetics
chemical synthesis
chemistry
metabolism
pharmacology
Antineoplastic Agents
Cisplatin
Dogs
Drug Evaluation, Preclinical
Ferrets
Guinea Pigs
Humans
Morpholines
chemical synthesis
chemistry
metabolism
pharmacology
Prodrugs
chemical synthesis
chemistry
metabolism
pharmacology
Rats
Receptors, Neurokinin-1
antagonists & inhibitors
Solubility
Stereoisomerism
Structure-Activity Relationship
Vomiting
chemically induced
drug therapy
Water
10854512
2000
06
29
2000
06
29
2004
11
17
1432-2218
14
1
2000
Jan
Surgical endoscopy
Surg Endosc
Inflammatory fibroid polyp of the duodenum.
86
Duodenal inflammatory fibroid polyps (IFP) are extemely rare lesions indistinguishable from submucosal tumors by endoscopic inspection alone. Like gastric inflammatory fibroid polyps, they can be managed by endoscopic polypectomy or mucosectomy. However, preoperative diagnosis of this benign lesion is difficult. Here we present a case of duodenal IFP causing gastrointestinal bleeding that was evaluated by endoscopic ultrasound before surgical removal. On endosonography, the duodenal IFP appeared as a coarsely heterogeneous isoechoic and hypoechoic mass circumscribed by a distinct margin and arising from the third layer of the duodenal wall. The endosonographic appearance of this lesion was in marked contrast to that previously reported for gastric IFPs, which have tended to appear as hypoechoic homogeneous lesions with indistinct margins. Endosonographic evaluation of suspected IFPs before endoscopic or surgical treatment is useful. However, the endosonographic appearances of duodenal and gastric IFPs may be significantly different, possibly because of differences in the makeup of the duodenal and gastric walls.
Division of Gastroenterology, ChangHua Christian Medical Center, ChangHua, Taiwan.
Soon
M S
MS
Lin
O S
OS
eng
Case Reports
Journal Article
1999
11
25
UNITED STATES
Surg Endosc
8806653
0930-2794
IM
Duodenal Neoplasms
complications
pathology
surgery
Duodenitis
etiology
pathology
surgery
Endoscopy, Gastrointestinal
Endosonography
Female
Fibroma
pathology
surgery
Gastric Mucosa
pathology
Gastrointestinal Hemorrhage
etiology
pathology
surgery
Humans
Intestinal Polyps
complications
pathology
surgery
Middle Aged
10972993
2000
09
26
2000
09
26
2008
11
21
0899-1987
28
4
2000
Aug
Molecular carcinogenesis
Mol. Carcinog.
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
236-46
Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet structural mutations in these genes are infrequent in sporadic cancer cases. To better define the involvement of these genes in sporadic cancers, we characterized expression levels of BRCA1 and BRCA2 transcripts in cancer cell lines derived from neoplasms of the ovary, prostate, and breast and compared them with those expressed in primary cultures of normal epithelial cells established from these organs. We observed upregulation of BRCA1 and/or BRCA2 expression in six of seven ovarian cancer cell lines (OVCA420, OVCA429, OVCA432, ALST, DOV13, and SKOV3) when compared with levels found in normal ovary surface epithelial cells. Furthermore, five cancerous or immortalized prostatic epithelial cell lines (BPH-1, TSU-Pr1, LNCaP, PC-3, and DU145) also expressed higher levels of BRCA1 and/or BRCA2 mRNA than did primary cultures of normal prostatic epithelial cells. In contrast, only the estrogen receptor-positive MCF-7 cell line overexpressed these messages, whereas the estrogen receptor-negative breast cancer cell lines Hs578T, MDA-MB-231, and MDA-MB-468 showed no change in expression levels when compared with normal breast epithelial cells. In addition, expanding on our recent identification of a novel BRCA2 transcript variant carrying an in-frame exon 12 deletion (BRCA2 delta 12), we report increased expression of this variant in several ovarian, prostate, and mammary cancer cell lines (OVCA420, OVCA433, ALST, DOV13, SKOV3, TSU-Pr1, DU145, and MDA-MB-468). Most notably, high levels of BRCA2 delta 12 mRNA were detected in an estrogen receptor-positive breast cancer cell line, MCF-7, and in an androgen-independent prostate cancer cell line, DU-145. Interestingly, the wild-type BRCA2 transcript was barely detectable in DU145, which could be used as a model system for future investigations on BRCA2 delta 12 function. Taken together, our data suggest disruption of BRCA1 and/or BRCA2 gene expression in certain epithelial cancer cell lines of the ovary, prostate, and breast. Because wild-type BRCA1 and BRCA2 gene products increase during cell-cycle progression and are believed to exert growth-inhibitory action, enhanced expression of these genes in cancer cells may represent a negative feedback mechanism for curbing proliferation in fast-growing cells. At present, the functionality of BRCA2 delta 12 remains elusive.
Copyright 2000 Wiley-Liss, Inc.
Department of Biology, Tufts University, Medford, Massachusetts, USA.
Rauh-Adelmann
C
C
Lau
K M
KM
Sabeti
N
N
Long
J P
JP
Mok
S C
SC
Ho
S M
SM
eng
C69453
PHS HHS
United States
CA15576
CA
NCI NIH HHS
United States
CA62269
CA
NCI NIH HHS
United States
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
UNITED STATES
Mol Carcinog
8811105
0899-1987
0
BRCA1 Protein
0
BRCA2 Protein
0
Neoplasm Proteins
0
RNA, Messenger
0
Transcription Factors
IM
BRCA1 Protein
genetics
BRCA2 Protein
Breast
metabolism
Breast Neoplasms
genetics
Cell Line
Epithelial Cells
metabolism
Exons
Female
Gene Expression Regulation, Neoplastic
Genes, BRCA1
Genetic Variation
Humans
Male
Neoplasm Proteins
genetics
Ovarian Neoplasms
genetics
Prostatic Neoplasms
genetics
RNA, Messenger
genetics
Sequence Deletion
Transcription Factors
genetics
Transcription, Genetic
Tumor Cells, Cultured
11025314
2001
01
05
2001
01
05
2006
11
15
0108-2701
56 ( Pt 10)
2000
Oct
Acta crystallographica. Section C, Crystal structure communications
Acta Crystallogr C
Multicentre hydrogen bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt.
1247-50
The title compound, (S)-(+)-4-[5-(2-oxo-4, 5-dihydroimidazol-1-ylsulfonyl)indolin-1 -ylcarbonyl ]anilinium chloride (S)-(+)-1-[1-(4-aminobenzoyl)indoline-5- sulfonyl]-4-phenyl-4, 5-dihydroimidazol-2-one, C(24)H(23)N(4)O(4)S(+).Cl(-). C(24)H(22)N(4)O(4)S, crystallizes in space group C2 from a CH(3)OH/CH(2)Cl(2) solution. In the crystal structure, there are two different conformers with their terminal C(6) aromatic rings mutually oriented at angles of 67.69 (14) and 61.16 (15) degrees. The distances of the terminal N atoms (of the two conformers) from the chloride ion are 3.110 (4) and 3.502 (4) A. There are eight distinct hydrogen bonds, i.e. four N-H...Cl, three N-H...O and one N-H...N, with one N-H group involved in a bifurcated hydrogen bond with two acceptors sharing the H atom. C-H...O contacts assist in the overall hydrogen-bonding process.
College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea. parki@cnu.ac.kr.
Park
K L
KL
Moon
B G
BG
Jung
S H
SH
Kim
J G
JG
Suh
I H
IH
eng
Journal Article
Research Support, Non-U.S. Gov't
DENMARK
Acta Crystallogr C
8305826
0108-2701
0
1-(1-(4-aminobenzoyl)indoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazol-2-one
0
Antineoplastic Agents
0
Imidazoles
0
Sulfones
IM
Antineoplastic Agents
chemistry
Crystallography, X-Ray
Hydrogen Bonding
Imidazoles
chemistry
Models, Molecular
Molecular Conformation
Stereoisomerism
Sulfones
chemistry
11056631
2000
12
01
0031-9007
85
19
2000
Nov
6
Physical review letters
Phys. Rev. Lett.
Dislocated epitaxial islands.
4088-91
Dislocation networks observed in CoSi (2) islands grown epitaxially on Si are compared with the results of dislocation-dynamics calculations. The calculations make use of the fact that image forces play a relatively minor role compared to line tension forces and dislocation-dislocation interactions. Remarkable agreement is achieved, demonstrating that this approach can be applied more generally to study dislocations in other mesostructures.
IBM Watson Research Center, P.O. Box 218, Yorktown Heights, New York 10598, USA.
Liu
X H
XH
Ross
F M
FM
Schwarz
K W
KW
eng
Journal Article
UNITED STATES
Phys Rev Lett
0401141
0031-9007
IM
11034741
2001
01
26
2001
08
02
2007
11
15
1469-493X
4
2000
Cochrane database of systematic reviews (Online)
Cochrane Database Syst Rev
Parent-training programmes for improving maternal psychosocial health.
CD002020
The prevalence of mental health problems in women is 1:3 and such problems tend to be persistent. There is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for the psychological health of the child. It is now thought that parenting programmes may have an important role to play in the improvement of maternal psychosocial health.
The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression and self-esteem.
A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR).
Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health.
A systematic critical appraisal of all included studies was undertaken using the Journal of the American Medical Association (JAMA) published criteria. The data were summarised using effect sizes but were not combined in a meta-analysis due to the small number of studies within each group and the presence of significant heterogeneity.
A total of 22 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. These 17 studies reported on a total of 59 outcomes including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. Approximately 22% of the outcomes measured suggested significant differences favouring the intervention group. A further 40% showed differences favouring the intervention group but which failed to achieve conventional levels of statistical significance, in some cases due to the small numbers that were used. Approximately 38% of outcomes suggested no evidence of effectiveness.
It is suggested that parenting programmes can make a significant contribution to the improvement of psychosocial health in mothers. While the critical appraisal suggests some variability in the quality of the included studies, it is concluded that there is sufficient evidence to support their use with diverse groups of parents. However, it is also suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required.
Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Oxford, UK, OX3 7LF. esther.coren@dphpc.ox.ac.uk
Barlow
J
J
Coren
E
E
eng
Journal Article
Review
England
Cochrane Database Syst Rev
100909747
1361-6137
IM
Cochrane Database Syst Rev. 2001;(2):CD002020
11406024
Anxiety
therapy
Depression
therapy
Female
Humans
Maternal Behavior
psychology
Mother-Child Relations
Parenting
Program Evaluation
Randomized Controlled Trials as Topic
Self Concept
99
11237011
2001
03
09
2001
03
22
2006
11
15
0028-0836
409
6822
2001
Feb
15
Nature
Nature
Initial sequencing and analysis of the human genome.
860-921
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.
Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA. lander@genome.wi.mit.edu
Lander
E S
ES
Linton
L M
LM
Birren
B
B
Nusbaum
C
C
Zody
M C
MC
Baldwin
J
J
Devon
K
K
Dewar
K
K
Doyle
M
M
FitzHugh
W
W
Funke
R
R
Gage
D
D
Harris
K
K
Heaford
A
A
Howland
J
J
Kann
L
L
Lehoczky
J
J
LeVine
R
R
McEwan
P
P
McKernan
K
K
Meldrim
J
J
Mesirov
J P
JP
Miranda
C
C
Morris
W
W
Naylor
J
J
Raymond
C
C
Rosetti
M
M
Santos
R
R
Sheridan
A
A
Sougnez
C
C
Stange-Thomann
N
N
Stojanovic
N
N
Subramanian
A
A
Wyman
D
D
Rogers
J
J
Sulston
J
J
Ainscough
R
R
Beck
S
S
Bentley
D
D
Burton
J
J
Clee
C
C
Carter
N
N
Coulson
A
A
Deadman
R
R
Deloukas
P
P
Dunham
A
A
Dunham
I
I
Durbin
R
R
French
L
L
Grafham
D
D
Gregory
S
S
Hubbard
T
T
Humphray
S
S
Hunt
A
A
Jones
M
M
Lloyd
C
C
McMurray
A
A
Matthews
L
L
Mercer
S
S
Milne
S
S
Mullikin
J C
JC
Mungall
A
A
Plumb
R
R
Ross
M
M
Shownkeen
R
R
Sims
S
S
Waterston
R H
RH
Wilson
R K
RK
Hillier
L W
LW
McPherson
J D
JD
Marra
M A
MA
Mardis
E R
ER
Fulton
L A
LA
Chinwalla
A T
AT
Pepin
K H
KH
Gish
W R
WR
Chissoe
S L
SL
Wendl
M C
MC
Delehaunty
K D
KD
Miner
T L
TL
Delehaunty
A
A
Kramer
J B
JB
Cook
L L
LL
Fulton
R S
RS
Johnson
D L
DL
Minx
P J
PJ
Clifton
S W
SW
Hawkins
T
T
Branscomb
E
E
Predki
P
P
Richardson
P
P
Wenning
S
S
Slezak
T
T
Doggett
N
N
Cheng
J F
JF
Olsen
A
A
Lucas
S
S
Elkin
C
C
Uberbacher
E
E
Frazier
M
M
Gibbs
R A
RA
Muzny
D M
DM
Scherer
S E
SE
Bouck
J B
JB
Sodergren
E J
EJ
Worley
K C
KC
Rives
C M
CM
Gorrell
J H
JH
Metzker
M L
ML
Naylor
S L
SL
Kucherlapati
R S
RS
Nelson
D L
DL
Weinstock
G M
GM
Sakaki
Y
Y
Fujiyama
A
A
Hattori
M
M
Yada
T
T
Toyoda
A
A
Itoh
T
T
Kawagoe
C
C
Watanabe
H
H
Totoki
Y
Y
Taylor
T
T
Weissenbach
J
J
Heilig
R
R
Saurin
W
W
Artiguenave
F
F
Brottier
P
P
Bruls
T
T
Pelletier
E
E
Robert
C
C
Wincker
P
P
Smith
D R
DR
Doucette-Stamm
L
L
Rubenfield
M
M
Weinstock
K
K
Lee
H M
HM
Dubois
J
J
Rosenthal
A
A
Platzer
M
M
Nyakatura
G
G
Taudien
S
S
Rump
A
A
Yang
H
H
Yu
J
J
Wang
J
J
Huang
G
G
Gu
J
J
Hood
L
L
Rowen
L
L
Madan
A
A
Qin
S
S
Davis
R W
RW
Federspiel
N A
NA
Abola
A P
AP
Proctor
M J
MJ
Myers
R M
RM
Schmutz
J
J
Dickson
M
M
Grimwood
J
J
Cox
D R
DR
Olson
M V
MV
Kaul
R
R
Raymond
C
C
Shimizu
N
N
Kawasaki
K
K
Minoshima
S
S
Evans
G A
GA
Athanasiou
M
M
Schultz
R
R
Roe
B A
BA
Chen
F
F
Pan
H
H
Ramser
J
J
Lehrach
H
H
Reinhardt
R
R
McCombie
W R
WR
de la Bastide
M
M
Dedhia
N
N
Blöcker
H
H
Hornischer
K
K
Nordsiek
G
G
Agarwala
R
R
Aravind
L
L
Bailey
J A
JA
Bateman
A
A
Batzoglou
S
S
Birney
E
E
Bork
P
P
Brown
D G
DG
Burge
C B
CB
Cerutti
L
L
Chen
H C
HC
Church
D
D
Clamp
M
M
Copley
R R
RR
Doerks
T
T
Eddy
S R
SR
Eichler
E E
EE
Furey
T S
TS
Galagan
J
J
Gilbert
J G
JG
Harmon
C
C
Hayashizaki
Y
Y
Haussler
D
D
Hermjakob
H
H
Hokamp
K
K
Jang
W
W
Johnson
L S
LS
Jones
T A
TA
Kasif
S
S
Kaspryzk
A
A
Kennedy
S
S
Kent
W J
WJ
Kitts
P
P
Koonin
E V
EV
Korf
I
I
Kulp
D
D
Lancet
D
D
Lowe
T M
TM
McLysaght
A
A
Mikkelsen
T
T
Moran
J V
JV
Mulder
N
N
Pollara
V J
VJ
Ponting
C P
CP
Schuler
G
G
Schultz
J
J
Slater
G
G
Smit
A F
AF
Stupka
E
E
Szustakowski
J
J
Thierry-Mieg
D
D
Thierry-Mieg
J
J
Wagner
L
L
Wallis
J
J
Wheeler
R
R
Williams
A
A
Wolf
Y I
YI
Wolfe
K H
KH
Yang
S P
SP
Yeh
R F
RF
Collins
F
F
Guyer
M S
MS
Peterson
J
J
Felsenfeld
A
A
Wetterstrand
K A
KA
Patrinos
A
A
Morgan
M J
MJ
de Jong
P
P
Catanese
J J
JJ
Osoegawa
K
K
Shizuya
H
H
Choi
S
S
Chen
Y J
YJ
Szustakowki
J
J
International Human Genome Sequencing Consortium
eng
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
England
Nature
0410462
0028-0836
0
DNA Transposable Elements
0
Proteins
0
Proteome
63231-63-0
RNA
IM
Nature. 2001 Oct 18;413(6857):660
11606985
Nature. 2001 Feb 15;409(6822):822-3
11236997
Nature. 2001 Feb 15;409(6822):818-20
11236994
Nature. 2001 Feb 15;409(6822):820-1
11236995
Nature. 2001 Feb 15;409(6822):814-6
11236992
Nature 2001 Jun 7;411(6838):720
Szustakowki, J [corrected to Szustakowski, J]
Nature 2001 Aug 2;412(6846):565
Animals
Chromosome Mapping
Conserved Sequence
CpG Islands
DNA Transposable Elements
Databases, Factual
Drug Industry
Evolution, Molecular
Forecasting
GC Rich Sequence
Gene Duplication
Genes
Genetic Diseases, Inborn
Genetics, Medical
Genome, Human
Human Genome Project
Humans
Mutation
Private Sector
Proteins
genetics
Proteome
Public Sector
RNA
genetics
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
methods
Species Specificity
11243089
2001
03
12
2001
05
17
2006
11
15
0019-557X
43
1
1999 Jan-Mar
Indian journal of public health
Indian J Public Health
Nutritional status of pavement dweller children of Calcutta City.
49-54
Pavement dwelling is likely to aggravate malnutrition among its residents due to extreme poverty, lack of dwelling and access to food and their exposure to polluted environment. Paucity of information about nutritional status of street children compared to that among urban slum dwellers, squatters or rural/tribal population is quite evident. The present study revealed the magnitude of Protein Energy Malnutrition (PEM) and few associated factors among a sample of 435 underfives belonging to pavement dweller families and selected randomly from clusters of such families, from each of the five geographical sectors of Calcutta city. Overall prevalence of PEM was found almost similar (about 70%) to that among other 'urban poor' children viz. slum dwellers etc., but about 16% of them were found severely undernourished (Grade III & V of IAP classification of PEM). About 35% and 70% of street dweller children had wasting and stunting respectively. Severe PEM (Grade III & IV) was more prevalent among 12-23 months old, girl child, those belonged to illiterate parents and housewife mothers rather than wage earners. It also did increase with increase of birth rate of decrease of birth interval.
Department of Community Medicine, Medical College, Calcutta.
Ray
S K
SK
Mishra
R
R
Biswas
R
R
Kumar
S
S
Halder
A
A
Chatterjee
T
T
eng
Journal Article
Research Support, Non-U.S. Gov't
India
Indian J Public Health
0400673
0019-557X
IM
J
Child, Preschool
Cluster Analysis
Cross-Sectional Studies
Educational Status
Female
Humans
India
epidemiology
Infant
Male
Nutritional Status
Poverty
Prejudice
Prevalence
Protein-Energy Malnutrition
epidemiology
143717
00288124
This document presents a cross-sectional survey concerning the magnitude of protein energy malnutrition (PEM) and its associated factors among 435 under-5 pavement-dwelling children in Calcutta. Results revealed that 69.43% were undernourished and that 16% of them were suffering from severe malnutrition (grade III and IV of the Indian Academy of Pediatrics criteria for PEM). The 24-35 month age group had the highest prevalence of malnutrition (82.93%) followed by the 36-47 and 12-23 month age groups with prevalences of 76.19% and 74.03%, respectively. Prevalence of severe grade malnutrition was noted to be three times higher in females (24.76%) than males (8.45%), and among families it increased in direct proportion to birth rate and inverse proportion to birth interval. Moreover, children of illiterate parents and nonworking mothers had a higher incidence of severe PEM. Simple measures such as exclusive breast-feeding and timely complementary feeding as well as measures directed toward birth spacing and limiting family size should be implemented to solve the problem of malnutrition.
Age Factors
Asia
Child
Child Nutrition
Demographic Factors
Developing Countries
Diseases
Geographic Factors
Health
Homeless Persons
India
Malnutrition
Nutrition
Nutrition Disorders
Population
Population Characteristics
Research Methodology
Research Report
Residence Characteristics
Sampling Studies
Southern Asia
Spatial Distribution
Studies
Surveys
Urban Population
Youth
TJ: INDIAN JOURNAL OF PUBLIC HEALTH.
11238657
2001
03
12
2001
05
17
2006
11
15
0022-1767
166
6
2001
Mar
15
Journal of immunology (Baltimore, Md. : 1950)
J. Immunol.
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.
4083-91
Increasing evidence suggests that a continuous release of histamine from mast cells occurs in the airways of asthmatic patients and that histamine may modulate functions of other inflammatory cells such as macrophages. In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Enhancement of beta-glucuronidase release induced by histamine was evident after 30 min and peaked at 90 min, whereas that of IL-6 required 2-6 h of incubation. These effects were reproduced by the H(1) agonist (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptane carboxamide but not by the H(2) agonist dimaprit. Furthermore, histamine induced a concentration-dependent increase of intracellular Ca(2+) concentrations ([Ca(2+)](i)) that followed three types of response, one characterized by a rapid increase, a second in which [Ca(2+)](i) displays a slow but progressive increase, and a third characterized by an oscillatory pattern. Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways.
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy. triggian@unina.it
Triggiani
M
M
Gentile
M
M
Secondo
A
A
Granata
F
F
Oriente
A
A
Taglialatela
M
M
Annunziato
L
L
Marone
G
G
eng
Journal Article
Research Support, Non-U.S. Gov't
United States
J Immunol
2985117R
0022-1767
0
Histamine Agonists
0
Histamine H1 Antagonists
0
Histamine H2 Antagonists
0
Interleukin-6
0
RNA, Messenger
0
Receptors, Histamine H1
0
Toluidines
103827-15-2
6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide
51-45-6
Histamine
65119-89-3
Dimaprit
7440-70-2
Calcium
EC 3.2.1.31
Glucuronidase
AIM
IM
Calcium
metabolism
physiology
Cytosol
metabolism
Dimaprit
pharmacology
Dose-Response Relationship, Immunologic
Exocytosis
immunology
Glucuronidase
secretion
Histamine
analogs & derivatives
pharmacology
physiology
Histamine Agonists
pharmacology
Histamine H1 Antagonists
pharmacology
Histamine H2 Antagonists
pharmacology
Humans
Interleukin-6
biosynthesis
genetics
secretion
Lung
cytology
enzymology
immunology
metabolism
Macrophages, Alveolar
enzymology
immunology
metabolism
secretion
RNA, Messenger
biosynthesis
Receptors, Histamine H1
metabolism
Toluidines
pharmacology
Up-Regulation
immunology
11279676
2001
03
30
2001
12
07
2007
11
15
1469-493X
1
2001
Cochrane database of systematic reviews (Online)
Cochrane Database Syst Rev
Elective versus selective caesarean section for delivery of the small baby.
CD000078
Elective caesarean delivery for women in preterm labour might reduce the chances of fetal or neonatal death, but it might also increase the risk of maternal morbidity.
To assess the effects of a policy of elective caesarean delivery versus selective caesarean delivery for women in preterm labour.
The Cochrane Pregnancy and Childbirth Group trials register was searched. Date of last search: September 2000.
Randomised trials comparing a policy of elective caesarean delivery versus expectant management with recourse to caesarean section.
One reviewer assessed eligibility and trial quality, and both contributed to the update.
Six studies involving 122 women were included. All trials reported recruiting difficulties. No significant differences between elective and selective policies for caesarean delivery were found for fetal, neonatal or maternal outcomes.
There is not enough evidence to evaluate the use of a policy for elective caesarean delivery for small babies. Randomised trials in this area are likely to continue to experience recruitment problems. However, it still may be possible to investigate elective caesarean delivery in preterm babies with cephalic presentations.
Health Services Research Unit, The Polwarth Building, Foresterhill, Aberdeen, UK, AB9 2ZD. a.grant@abdn.ac.uk
Grant
A
A
Glazener
C M
CM
eng
Journal Article
Review
England
Cochrane Database Syst Rev
100909747
1361-6137
IM
Cochrane Database Syst Rev. 2001;(2):CD000078
11405950
Cochrane Database Syst Rev. 2000;(2):CD000078
10796117
Cesarean Section
Female
Humans
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature
Pregnancy
Randomized Controlled Trials as Topic
Surgical Procedures, Elective
21
11406024
2001
06
14
2002
02
28
2007
11
15
1469-493X
2
2001
Cochrane database of systematic reviews (Online)
Cochrane Database Syst Rev
Parent-training programmes for improving maternal psychosocial health.
CD002020
Mental health problems are common, and there is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for both the short and long-term psychological health of the child. The use of parenting programmes is increasing in the UK and evidence of their effectiveness in improving outcomes for mothers is now required.
The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression, and self-esteem.
A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR).
Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health.
A systematic critical appraisal of all included studies was undertaken using a modified version of the Journal of the American Medical Association (JAMA) published criteria. The treatment effect for each outcome in each study was standardised by dividing the mean difference in post-intervention scores for the intervention and treatment group, by the pooled standard deviation, to produce an effect size. Where appropriate the results were then combined in a meta-analysis using a fixed-effect model, and 95% confidence intervals were used to assess the significance of the findings.
A total of 23 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. The 17 studies provided a total of 59 assessments of outcome on a range of aspects of psychosocial functioning including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. There was only sufficient data, however, on five outcomes (depression; anxiety/stress; self-esteem; social support; and relationship with spouse/marital adjustment) to combine the results in a meta-analysis. The meta-analyses show statistically significant results favouring the intervention group as regards depression; anxiety/stress; self-esteem; and relationship with spouse/marital adjustment. The meta-analysis of the social support data, however, showed no evidence of effectiveness. These results suggest that parenting programmes, irrespective of the type (or content) of programme, can be effective in improving important aspects of maternal psycho-social functioning. Of the data summarising the effectiveness of the different types of parenting programmes, which it was not possible to combine in a meta-analysis, approximately 22% of the outcomes measured, showed significant differences between the intervention group and the control group. A further 40% showed medium to large non-significant differences favouring the intervention group. Approximately one-third of outcomes showed small non-significant differences or no evidence of effectiveness. A meta-analysis of the follow-up data on three outcomes was also conducted - depression, self-esteem and relationship with spouse/marital adjustment. The results show that there was a continued improvement in self-esteem, depression and marital adjustment at follow-up, although the latter two findings were not statistically significant.
It is suggested that parenting programmes can make a significant contribution to short-term psychosocial health in mothers, and that the limited follow-up data available suggest that these are maintained over time. However, the overall paucity of long-term follow-up data points to the need for further evidence concerning the long-term effectiveness of parenting programmes on maternal mental health. Furthermore, it is suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required.
Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. esther.coren@public-health.oxford.ac.uk
Barlow
J
J
Coren
E
E
eng
Journal Article
Review
England
Cochrane Database Syst Rev
100909747
1361-6137
IM
Cochrane Database Syst Rev. 2004;(1):CD002020
14973981
Cochrane Database Syst Rev. 2000;(4):CD002020
11034741
Anxiety
therapy
Depression
therapy
Female
Humans
Maternal Behavior
psychology
Maternal Welfare
Mother-Child Relations
Parenting
Program Evaluation
Randomized Controlled Trials as Topic
Self Concept
100
11428848
2001
06
28
2001
09
27
2007
11
15
0195-668X
22
13
2001
Jul
European heart journal
Eur. Heart J.
Indications for implantable cardioverter defibrillator (ICD) therapy. Study Group on Guidelines on ICDs of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology.
1074-81
Heart Lung Center Utrecht, University Medical Center, The Netherlands.
Hauer
R N
RN
Aliot
E
E
Block
M
M
Capucci
A
A
Lüderitz
B
B
Santini
M
M
Vardas
P E
PE
European Society of Cardiology. Working Group on Arrhythmias and Working Group on Cardiac Pacing
eng
Guideline
Journal Article
Practice Guideline
England
Eur Heart J
8006263
0195-668X
IM
Arrhythmias, Cardiac
etiology
therapy
Arrhythmogenic Right Ventricular Dysplasia
therapy
Cardiomyopathy, Dilated
therapy
Cardiomyopathy, Hypertrophic
therapy
Coronary Disease
therapy
Death, Sudden, Cardiac
prevention & control
Defibrillators, Implantable
Heart Valve Diseases
therapy
Humans
Long QT Syndrome
therapy
Ventricular Fibrillation
therapy
11441930
2001
07
09
2001
07
19
2009
05
12
0284-186X
40
2-3
2001
Acta oncologica (Stockholm, Sweden)
Acta Oncol
Assessment of quality of life during chemotherapy.
175-84
Increasingly more aggressive chemotherapy together with expected small differences between treatments with respect to objective endpoints has heightened awareness about the importance of addressing how patients experience and value the impact that treatment has had on their overall life situation. Assessment of a patient's quality of life (QoL) is now conceptually viewed as an important complement to traditional objective evaluation measures. It was therefore considered important to review the basis for the assessment of this endpoint when The Swedish Council of Technology Assessment in Health Care (SBU) performed a systematic overview of chemotherapy effects in several tumour types. The group came to the following conclusions: QoL assessments, mostly by patient self-reporting in questionnaires, have come increasingly into use during the past decade. A number of general, cancer-specific and cancer diagnosis-specific instruments have been developed. There is at present little need for development of new cancer instruments, although specific treatment modalities and tumour types may need new additional modules. A predefined hypothesis should determine the instrument to be used. Since the selection of a QoL instrument in a specific study influences both the results and the conclusions, it is essential to carefully select the instrument or instruments that have the greatest likelihood of identifying relevant differences between treatment alternatives. Interpretation of QoL data is more difficult than interpretation of objective endpoints such as survival time, objective response rates or toxicity. Despite these difficulties, QoL analyses have provided new insights into the advantages and disadvantages of various treatments not provided by traditional end-points. Some palliative treatments seemingly increase patients' QoL despite side-effects or the lack of, or marginal, increases in survival. When using potentially curative chemotherapy, it is not a matter of when the treatment should be started, but rather when it should be concluded. When using less active chemotherapy, the expected small therapeutic gains must be weighed against the QoL costs of using the therapy: does the toxicity and/or the inconvenience of the proposed treatment justify the expected gain? When it is found that the strain on the patient is greater than the effects of the cancer, treatment must be discontinued. It is not possible to determine whether or not the advantages of palliative chemotherapy are worth their costs without knowledge about patients' personal values regarding the influence on factors of relevance for QoL. The mostly used QoL questionnaires do not consider individual preferences, which therefore need to be addressed in the dialogue with the patient. QoL assessment is clearly in need of further methodological improvement before this endpoint can be regarded as fully established with respect to ability to provide unequivocally useful data in clinical trials. The multitude of questionnaires, missing data, lack of pre-study hypotheses of relevant differences between treatments and data multiplicity giving a risk for chance findings are examples of serious methodological problems. Patient response-shifts over time further complicate the interpretation of the data. Thus, QoL data, also from seemingly well-performed clinical trials, have to be interpreted cautiously. The international development during recent years has aimed at creating increased standardization of QoL measures. This has created greater possibilities to compare results from different trials. Hopefully, this also implies that it will be possible to draw firmer conclusions from QoL measurements in recently completed or ongoing trials than has been the case previously. QoL assessments are resource demanding even when short standardized questionnaires are used. Since cancer patients also generally give priority to anticancer effects over toxicity and convenience, QoL assessments in clinical trials are motivated mainly in study settings comparing treatments without expected major differences of outcome in objective endpoints.
Department of Oncology, University Hospital, Lund, Sweden.
Gunnars
B
B
Nygren
P
P
Glimelius
B
B
SBU-group. Swedish Council of Technology Assessment in Health Care
eng
Journal Article
Review
Norway
Acta Oncol
8709065
0284-186X
0
Antineoplastic Agents
IM
Antineoplastic Agents
adverse effects
therapeutic use
Endpoint Determination
Humans
Neoplasms
drug therapy
Outcome Assessment (Health Care)
Palliative Care
Patient Satisfaction
Quality of Life
Questionnaires
112
11442735
2001
07
09
2001
10
04
2006
11
15
0303-6979
28
8
2001
Aug
Journal of clinical periodontology
J. Clin. Periodontol.
Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches.
753-61
In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated.
105 adult patients with moderately advanced chronic periodontitis from 3 centres participated in the trial. Each patient had to present with at least 8 periodontal sites in 2 jaw quadrants with a probing pocket depth (PPD) of > or =5 mm and bleeding following pocket probing (BoP), out of which at least 2 sites had to be > or =7 mm and a further 2 sites > or =6 mm. Following a baseline examination, including assessments of plaque, PPD, clinical attachment level (CAL) and BoP, careful instruction in oral hygiene was given. The patients were then randomly assigned to one of two treatment groups: scaling/root planing (SRP) with local analgesia or debridement (supra- and subgingival ultrasonic instrumentation without analgesia). The "SRP" group received a single episode of full-mouth supra-/subgingival scaling and root planing under local analgesia. In addition, at a 3-month recall visit, a full-mouth supra-/subgingival debridement using ultrasonic instrumentation was provided. This was followed by subgingival application of an 8.5% w/w doxycycline polymer at sites with a remaining PPD of > or =5 mm. The patients of the "debridement" group were initially subjected to a 45-minute full-mouth debridement with the use of an ultrasonic instrument and without administration of local analgesia, and followed by application of doxycycline in sites with a PPD of > or =5 mm. At month 3, sites with a remaining PPD of > or =5 mm were subjected to scaling and root planing. Clinical re-examinations were performed at 3 and 6 months.
At 3 months, the proportion of sites showing PPD of < or =4 mm was significantly higher in the "debridement" group than in the "SRP" group (58% versus 50%; p<0.05). The CAL gain at 3 months amounted to 0.8 mm in the "debridement" group and 0.5 mm in the "SRP" group (p=0.064). The proportion of sites demonstrating a clinically significant CAL gain (> or =2 mm) was higher in the "debridement" group than in the "SRP" group (38% versus 30%; p<0.05). At the 6-month examination, no statistically significant differences in PPD or CAL were found between the two treatment groups. BoP was significantly lower for the "debridement" group than for the "SRP" group (p<0.001) both at 3- and 6 months. The mean total treatment time (baseline and 3-month) for the "SRP" patients was 3:11 h, compared to 2:00 h for the patients in the "debridement" group (p<0.001).
The results indicate that simplified subgingival instrumentation combined with local application of doxycycline in deep periodontal sites can be considered as a justified approach for non-surgical treatment of chronic periodontitis.
Department of Periodontology, Institute of Odontology, Göteborg University, SE 405 30 Göteborg, Sweden. wennstrom@odontologi.gu.se
Wennström
J L
JL
Newman
H N
HN
MacNeill
S R
SR
Killoy
W J
WJ
Griffiths
G S
GS
Gillam
D G
DG
Krok
L
L
Needleman
I G
IG
Weiss
G
G
Garrett
S
S
eng
fre
ger
Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Denmark
J Clin Periodontol
0425123
0303-6979
0
Anti-Bacterial Agents
24390-14-5
doxycycline hyclate
564-25-0
Doxycycline
D
IM
Adult
Aged
Anti-Bacterial Agents
administration & dosage
Chronic Disease
Clinical Protocols
Cost-Benefit Analysis
Debridement
Dental Scaling
methods
Doxycycline
administration & dosage
analogs & derivatives
Drug Compounding
Female
Gingival Hemorrhage
etiology
Humans
Male
Middle Aged
Periodontal Pocket
pathology
Periodontitis
complications
drug therapy
pathology
therapy
Prospective Studies
Root Planing
methods
Single-Blind Method
Treatment Outcome
11488864
2001
08
07
2001
10
25
2006
11
15
0905-7161
12
4
2001
Aug
Clinical oral implants research
Clin Oral Implants Res
Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit.
350-7
Textured implant surfaces are thought to enhance endosseous integration. Torque removal forces have been used as a biomechanical measure of anchorage, or endosseous integration, in which the greater forces required to remove implants may be interpreted as an increase in the strength of bony integration. The purpose of this study was to compare the torque resistance to removal of screw-shaped titanium implants having a dual acid-etched surface (Osseotite) with implants having either a machined surface, or a titanium plasma spray surface that exhibited a significantly more complex surface topography. Three custom screw-shaped implant types - machined, dual acid-etched (DAE), and titanium plasma sprayed (TPS) - were used in this study. Each implant surface was characterized by scanning electron microscopy and optical profilometry. One DAE implant was placed into each distal femur of eighteen adult New Zealand White rabbits along with one of the other implant types. Thus, each rabbit received two DAE implants and one each of the machined, or TPS, implants. All implants measured 3.25 mm in diameter x 4.00 mm in length without holes, grooves or slots to resist rotation. Eighteen rabbits were used for reverse torque measurements. Groups of six rabbits were sacrificed following one, two and three month healing periods. Implants were removed by reverse torque rotation with a digital torque-measuring device. Three implants with the machined surface preparation failed to achieve endosseous integration. All other implants were anchored by bone. Mean torque values for machined, DAE and TPS implants at one, two and three months were 6.00+/-0.64 N-cm, 9.07+/-0.67 N-cm and 6.73+/-0.95 N-cm; 21.86+/-1.37 N-cm, 27.63+/-3.41 N-cm and 27.40+/-3.89 N-cm; and 27.48+/-1.61 N-cm, 44.28+/-4.53 N-cm and 59.23+/-3.88 N-cm, respectively. Clearly, at the earliest time point the stability of DAE implants was comparable to that of TPS implants, while that of the machined implants was an order of magnitude lower. The TPS implants increased resistance to reverse torque removal over the three-month period. The results of this study confirm our previous results that demonstrated enhanced bony anchorage to dual acid-etched implants as compared to machined implants. Furthermore, the present results indicate that dual acid etching of titanium enhances early endosseous integration to a level which is comparable to that achieved by the topographically more complex TPS surfaces.
Division of Associated Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA 90095, USA. pklok@ucla.edu
Klokkevold
P R
PR
Johnson
P
P
Dadgostari
S
S
Caputo
A
A
Davies
J E
JE
Nishimura
R D
RD
eng
fre
ger
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Denmark
Clin Oral Implants Res
9105713
0905-7161
0
Coated Materials, Biocompatible
0
Dental Implants
0
Sulfuric Acids
7440-32-6
Titanium
7647-01-0
Hydrochloric Acid
7664-93-9
sulfuric acid
D
Analysis of Variance
Animals
Coated Materials, Biocompatible
Dental Implantation, Endosseous
Dental Implants
Dental Polishing
Dental Prosthesis Design
Device Removal
Femur
Hydrochloric Acid
Implants, Experimental
Metallurgy
Osseointegration
Rabbits
Sulfuric Acids
Surface Properties
Titanium
Torque
11488868
2001
08
07
2001
10
25
2006
11
15
0905-7161
12
4
2001
Aug
Clinical oral implants research
Clin Oral Implants Res
Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases.
379-84
Porous beta-phase tricalcium phosphate particles (pTCP) (Cerasorb) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner-stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant-acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue.
Department of Oral Cell Biology, ACTA, Vrije Universiteit, Vander Boechorststraat 7, 1081 BT Amsterdam, Netherlands. IR.Zerbo.Ocb.ACTA@med.vu.nl
Zerbo
I R
IR
Bronckers
A L
AL
de Lange
G L
GL
van Beek
G J
GJ
Burger
E H
EH
eng
fre
ger
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Denmark
Clin Oral Implants Res
9105713
0905-7161
0
Bone Substitutes
0
Calcium Phosphates
0
beta-tricalcium phosphate
7758-87-4
tricalcium phosphate
D
Absorbable Implants
Aged
Alveolar Ridge Augmentation
methods
Bone Regeneration
drug effects
Bone Substitutes
pharmacology
Calcium Phosphates
pharmacology
Humans
Male
Mandible
surgery
Maxillary Sinus
surgery
Middle Aged
Oral Surgical Procedures, Preprosthetic
Porosity
11520209
2001
08
24
2001
09
27
2004
11
17
0022-2623
44
18
2001
Aug
30
Journal of medicinal chemistry
J. Med. Chem.
Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.
3001-13
This paper describes the synthesis of a series of azo compounds able to deliver 5-aminosalicylic acid (5-ASA) and a potent platelet activating factor (PAF) antagonist in a colon-specific manner for the purpose of treating ulcerative colitis. We found it possible to add an amino group on the aromatic moiety of our reported 1-[(1-acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine derivatives or on British Biotech compounds BB-882 and BB-823 maintaining a high level of activity as PAF antagonist. A selected compound UR-12715 (49c) showed an IC(50) of 8 nM in the in vitro PAF-induced aggregation assay, and an ID(50) of 29 microg/kg in the in vivo PAF-induced hypotension test in normotensive rats. Through attachment of 49c to the 5-ASA via azo functionality we obtained UR-12746 (70). Pharmacokinetics experiments with [14C]-70 allow us to reach the following conclusions, critical in the design of these new prodrugs of 5-ASA. Neither the whole molecule 70 nor the carrier 49c were absorbed after oral administration of [14C]-70 in rat as was demonstrated by the absence of plasma levels of radioactivity and the high recovery of it in feces. Effective cleavage of azo bond (84%) by microflora in the colon is achieved. These facts ensure high topical concentrations of 5-ASA and 49c in the colon. Additionally, 70 exhibited a potent anticolitic effect in the trinitrobenzenesulfonic acid-induced colitis model in the rat. This profile suggests that UR-12746 (70) provides an attractive new approach to the treatment of ulcerative colitis.
Research Center, J. Uriach & Cía.S.A., Degà Bahí 59-67, 08026 Barcelona, Spain. chem-carceller@uriach.com
Carceller
E
E
Salas
J
J
Merlos
M
M
Giral
M
M
Ferrando
R
R
Escamilla
I
I
Ramis
J
J
García-Rafanell
J
J
Forn
J
J
eng
Journal Article
United States
J Med Chem
9716531
0022-2623
0
1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine
0
Amines
0
Aminosalicylic Acids
0
Anti-Inflammatory Agents, Non-Steroidal
0
Aza Compounds
0
Azo Compounds
0
Imidazoles
0
Platelet Activating Factor
0
Prodrugs
0
Pyridines
0
UR 12746
2508-19-2
Trinitrobenzenesulfonic Acid
89-57-6
Mesalamine
IM
Amines
chemical synthesis
chemistry
pharmacology
Aminosalicylic Acids
Animals
Anti-Inflammatory Agents, Non-Steroidal
chemical synthesis
chemistry
pharmacokinetics
pharmacology
Aza Compounds
chemical synthesis
chemistry
pharmacology
Azo Compounds
chemical synthesis
chemistry
pharmacokinetics
pharmacology
Colitis, Ulcerative
chemically induced
drug therapy
Drug Evaluation, Preclinical
Female
Hypotension
drug therapy
Imidazoles
chemical synthesis
chemistry
pharmacology
Male
Mesalamine
chemical synthesis
chemistry
pharmacology
Platelet Activating Factor
antagonists & inhibitors
Platelet Aggregation
drug effects
Prodrugs
chemical synthesis
chemistry
pharmacokinetics
pharmacology
Pyridines
chemical synthesis
chemistry
pharmacology
Rats
Rats, Sprague-Dawley
Rats, Wistar
Stereoisomerism
Structure-Activity Relationship
Trinitrobenzenesulfonic Acid
11525160
2001
08
28
2001
08
30
2004
11
17
0250-5525
124
2000
Schweizerische medizinische Wochenschrift. Supplementum
Schweiz Med Wochenschr Suppl
32nd Annual meeting of the Swiss Society of Nephrology. Lausanne, 14-15 December 2000. Abstracts.
1S-20S
eng
fre
ger
Congresses
Overall
Switzerland
Schweiz Med Wochenschr Suppl
7708316
0250-5525
IM
Animals
Humans
Kidney Diseases
Nephrology
11524736
2001
08
28
2001
12
12
2006
11
15
1098-1004
18
3
2001
Sep
Human mutation
Hum. Mutat.
Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome.
251
Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Hum Mutat 18:251, 2001.
Copyright 2001 Wiley-Liss, Inc.
Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk
Comeglio
P
P
Evans
A L
AL
Brice
G W
GW
Child
A H
AH
eng
Journal Article
Research Support, Non-U.S. Gov't
United States
Hum Mutat
9215429
1059-7794
0
Microfilament Proteins
0
fibrillin
IM
Hum Mutat. 2001 Dec;18(6):546-7
11748851
Adult
Base Sequence
Child, Preschool
Female
Frameshift Mutation
Great Britain
Humans
Male
Marfan Syndrome
genetics
Microfilament Proteins
genetics
Middle Aged
Mutation
Mutation, Missense
Sequence Deletion
11543891
2001
09
06
2001
09
27
2010
10
15
0198-8859
62
9
2001
Sep
Human immunology
Hum. Immunol.
The origin of Palestinians and their genetic relatedness with other Mediterranean populations.
889-900
The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes. The comparison with other Mediterranean populations by using neighbor-joining dendrograms and correspondence analyses reveal that Palestinians are genetically very close to Jews and other Middle East populations, including Turks (Anatolians), Lebanese, Egyptians, Armenians, and Iranians. Archaeologic and genetic data support that both Jews and Palestinians came from the ancient Canaanites, who extensively mixed with Egyptians, Mesopotamian, and Anatolian peoples in ancient times. Thus, Palestinian-Jewish rivalry is based in cultural and religious, but not in genetic, differences. The relatively close relatedness of both Jews and Palestinians to western Mediterranean populations reflects the continuous circum-Mediterranean cultural and gene flow that have occurred in prehistoric and historic times. This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition.
Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es
Arnaiz-Villena
A
A
Elaiwa
N
N
Silvera
C
C
Rostom
A
A
Moscoso
J
J
Gómez-Casado
E
E
Allende
L
L
Varela
P
P
Martínez-Laso
J
J
eng
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Retracted Publication
United States
Hum Immunol
8010936
0198-8859
0
HLA Antigens
0
HLA-A Antigens
0
HLA-B Antigens
0
HLA-DQ Antigens
0
HLA-DQB1 antigen
0
HLA-DR Antigens
128338-86-3
HLA-DRB1 antigen
IM
Hum Immunol. 2001 Oct;62(10):1064
11600211
Suciu-Foca N, Lewis R. Hum Immunol. 2001 Oct;62(10):1063
11600210
Alleles
Arabs
genetics
Gene Frequency
Greece
ethnology
HLA Antigens
genetics
HLA-A Antigens
genetics
HLA-B Antigens
genetics
HLA-DQ Antigens
HLA-DR Antigens
genetics
Haplotypes
genetics
Humans
Islam
Israel
Jews
genetics
Linkage Disequilibrium
Mediterranean Region
Middle East
Phylogeny
Polymorphism, Genetic
genetics
11562649
2001
09
19
2002
02
22
2005
11
16
0891-5245
15
5
2001 Sep-Oct
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
J Pediatr Health Care
Educating parents about normal stool pattern changes in infants.
269-74
Pediatric Nurse Practitioner Program at Ohio State University College of Nursing, Columbus, USA.
Arias
A
A
Bennison
J
J
Justus
K
K
Thurman
D
D
eng
Journal Article
Review
United States
J Pediatr Health Care
8709735
0891-5245
N
J Pediatr Health Care. 2001 Sep-Oct;15(5):270-1
11858131
Adolescent
Child
Child, Preschool
Consumer Satisfaction
Defecation
Feces
chemistry
Health Education
methods
Humans
Infant
Infant, Newborn
Ohio
Parenting
13
11567133
2001
09
21
2001
10
04
2007
03
19
0036-8075
293
5538
2001
Sep
21
Science (New York, N.Y.)
Science
Changes in seismic anisotropy after volcanic eruptions: evidence from Mount Ruapehu.
2231-3
The eruptions of andesite volcanoes are explosively catastrophic and notoriously difficult to predict. Yet changes in shear waveforms observed after an eruption of Mount Ruapehu, New Zealand, suggest that forces generated by such volcanoes are powerful and dynamic enough to locally overprint the regional stress regime, which suggests a new method of monitoring volcanoes for future eruptions. These results show a change in shear-wave polarization with time and are interpreted as being due to a localized stress regime caused by the volcano, with a release in pressure after the eruption.
Institute of Geophysics, Victoria University of Wellington, Wellington, New Zealand.
Miller
V
V
Savage
M
M
eng
Journal Article
United States
Science
0404511
0036-8075
11473127
2001
09
24
2001
11
01
2004
11
17
0021-9258
276
39
2001
Sep
28
The Journal of biological chemistry
J. Biol. Chem.
Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.
36520-9
We have used the highly selective alpha(4)beta(1) inhibitor 2S-[(1-benzenesulfonyl-pyrrolidine-2S-carbonyl)-amino]-4-[4-methyl-2S-(methyl-[2-[4-(3-o-tolyl-ureido)-phenyl]-acetyl]-amino)-pentanoylamino]-butyric acid (BIO7662) as a model ligand to study alpha(4)beta(1) integrin-ligand interactions on Jurkat cells. Binding of [(35)S]BIO7662 to Jurkat cells was dependent on the presence of divalent cations and could be blocked by treatment with an excess of unlabeled inhibitor or with EDTA. K(D) values for the binding of BIO7662 to Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm Mg(2+), 1 mm Ca(2+) were <10 pm, indicating that it has a high affinity for both activated and nonactivated integrin. No binding was observed on alpha(4)beta(1) negative cells. Through an analysis of the metal ion dependences of ligand binding, several unexpected findings about alpha(4)beta(1) function were made. First, we observed that Ca(2+) binding to alpha(4)beta(1) was stimulated by the addition of BIO7662. From solution binding studies on purified alpha(4)beta(1), two types of Ca(2+)-binding sites were identified, one dependent upon and the other independent of BIO7662 binding. Second, we observed that the metal ion dependence of ligand binding was affected by the affinity of the ligand for alpha(4)beta(1). ED(50) values for the metal ion dependence of the binding of BIO7762 and the binding of a lower affinity ligand, BIO1211, differed by 2-fold for Mn(2+), 30-fold for Mg(2+), and >1000-fold for Ca(2+). Low Ca(2+) (ED(50) = 5-10 microm) stimulated the binding of BIO7662 to alpha(4)beta(1). The effects of microm Ca(2+) closely resembled the effects of Mn(2+) on alpha(4)beta(1) function. Third, we observed that the rate of BIO7662 binding was dependent on the metal ion concentration and that the ED(50) for the metal ion dependence of BIO7662 binding was affected by the concentration of the BIO7662. These studies point to an even more complex interplay between metal ion and ligand binding than previously appreciated and provide evidence for a three-component coupled equilibrium model for metal ion-dependent binding of ligands to alpha(4)beta(1).
Biogen, Inc., Cambridge, Massachusetts 02142, USA.
Chen
L L
LL
Whitty
A
A
Scott
D
D
Lee
W C
WC
Cornebise
M
M
Adams
S P
SP
Petter
R C
RC
Lobb
R R
RR
Pepinsky
R B
RB
eng
Journal Article
2001
07
25
United States
J Biol Chem
2985121R
0021-9258
0
2-((1-benzenesulfonylpyrrolidine-2-carbonyl)amino)-4-(4-methyl-2-(methyl-(2-(4-(3-o-tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid
0
Benzoic Acids
0
Cations
0
Dipeptides
0
Integrin alpha4beta1
0
Integrins
0
Ions
0
Ligands
0
Phenylurea Compounds
0
Receptors, Lymphocyte Homing
60-00-4
Edetic Acid
7439-95-4
Magnesium
7439-96-5
Manganese
7440-70-2
Calcium
IM
Benzoic Acids
pharmacology
Calcium
metabolism
pharmacology
Cations
Dipeptides
pharmacology
Dose-Response Relationship, Drug
Edetic Acid
pharmacology
Humans
Integrin alpha4beta1
Integrins
antagonists & inhibitors
chemistry
metabolism
Ions
Jurkat Cells
Kinetics
Ligands
Magnesium
pharmacology
Manganese
pharmacology
Models, Chemical
Phenylurea Compounds
pharmacology
Protein Binding
Receptors, Lymphocyte Homing
antagonists & inhibitors
chemistry
metabolism
Time Factors
11583040
2001
10
02
2001
10
04
2006
11
15
0084-6597
28
2000
Annual review of earth and planetary sciences
Annu Rev Earth Planet Sci
Understanding oblique impacts from experiments, observations, and modeling.
141-67
Natural impacts in which the projectile strikes the target vertically are virtually nonexistent. Nevertheless, our inherent drive to simplify nature often causes us to suppose most impacts are nearly vertical. Recent theoretical, observational, and experimental work is improving this situation, but even with the current wealth of studies on impact cratering, the effect of impact angle on the final crater is not well understood. Although craters' rims may appear circular down to low impact angles, the distribution of ejecta around the crater is more sensitive to the angle of impact and currently serves as the best guide to obliquity of impacts. Experimental studies established that crater dimensions depend only on the vertical component of the impact velocity. The shock wave generated by the impact weakens with decreasing impact angle. As a result, melting and vaporization depend on impact angle; however, these processes do not seem to depend on the vertical component of the velocity alone. Finally, obliquity influences the fate of the projectile: in particular, the amount and velocity of ricochet are a strong function of impact angle.
Lunar and Planetary Lab., University of Arizona, Tucson, 84721, USA. betty@lpl.arizona.edu
Pierazzo
E
E
Melosh
H J
HJ
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
United States
Annu Rev Earth Planet Sci
100971465
0084-6597
S
Computer Simulation
Evolution, Planetary
Gravitation
Meteoroids
Models, Theoretical
Moon
Planets
96
00026602
NASA Discipline Exobiology
Non-NASA Center
Melosh
H J
HJ
U AZ, Tucson
Grant numbers: NAGW-5159, NAGW-428.
11580607
2001
10
02
2001
10
25
2006
11
15
0031-9007
87
13
2001
Sep
24
Physical review letters
Phys. Rev. Lett.
Maximal height scaling of kinetically growing surfaces.
136101
The scaling properties of the maximal height of a growing self-affine surface with a lateral extent L are considered. In the late-time regime its value measured relative to the evolving average height scales like the roughness: h*(L) approximately L alpha. For large values its distribution obeys logP(h*(L)) approximately (-)A(h*(L)/L(alpha))(a). In the early-time regime where the roughness grows as t(beta), we find h*(L) approximately t(beta)[lnL-(beta/alpha)lnt+C](1/b), where either b = a or b is the corresponding exponent of the velocity distribution. These properties are derived from scaling and extreme-value arguments. They are corroborated by numerical simulations and supported by exact results for surfaces in 1D with the asymptotic behavior of a Brownian path.
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA.
Raychaudhuri
S
S
Cranston
M
M
Przybyla
C
C
Shapir
Y
Y
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
2001
09
05
United States
Phys Rev Lett
0401141
0031-9007
IM
Bacteria
growth & development
Crystallization
Kinetics
Models, Theoretical
Surface Properties
11600210
2001
10
15
2001
10
25
0198-8859
62
10
2001
Oct
Human immunology
Hum. Immunol.
Editorial. Anthropology and genetic markers.
1063
Suciu-Foca
N
N
Lewis
R
R
eng
Retraction of Publication
United States
Hum Immunol
8010936
0198-8859
IM
Arnaiz-Villena A, Elaiwa N, Silvera C, Rostom A, Moscoso J, Gómez-Casado E, Allende L, Varela P, Martínez-Laso J. Hum Immunol. 2001 Sep;62(9):889-900
11543891
11600211
2001
10
15
2001
10
25
2004
11
17
0198-8859
62
10
2001
Oct
Human immunology
Hum. Immunol.
Letter from the ASHI president and council.
1064
Tyan
D B
DB
eng
Comment
Letter
United States
Hum Immunol
8010936
0198-8859
IM
Hum Immunol. 2001 Sep;62(9):889-900
11543891
Ethics, Medical
Histocompatibility
Humans
Immunogenetics
Publishing
Societies, Medical
United States
11686176
1982
01
01
1982
01
01
2007
11
15
0094-6133
1979 Jan-Feb
Malpractice digest
Malpract Dig
How physicians may minimize their chances of becoming involved in an informed consent claim.
1-2
Bower
John J
JJ
eng
Journal Article
United States
Malpract Dig
9879884
0094-6133
E
Consent Forms
Humans
Informed Consent
Jurisprudence
Malpractice
Records as Topic
12517
KIE BoB Subject Heading: INFORMED CONSENT
11686167
1990
10
17
1990
10
17
2007
11
15
8756-2057
25-26
1990 Jan-Apr
Reporter on human reproduction and the law
Report Hum Reprod Law
The dilemma of the Webster decision: deconstitutionalizing the trimester system.
276-92
Kindregan
Charles P
CP
eng
Journal Article
United States
Report Hum Reprod Law
100971950
8756-2057
E
Abortion, Eugenic
Abortion, Induced
Abortion, Therapeutic
Beginning of Human Life
Civil Rights
Embryonic and Fetal Development
Fetal Viability
Fetus
Government Regulation
Great Britain
History
Humans
International Cooperation
Internationality
Jurisprudence
Legislation as Topic
Life
Pregnancy
Pregnant Women
Privacy
Religion
Social Control, Formal
State Government
Supreme Court Decisions
United States
31521
Abortion Act 1967 (Great Britain)
Genetics and Reproduction
Legal Approach
Roe v. Wade
Webster v. Reproductive Health Services
63 fn.
KIE BoB Subject Heading: abortion/legal aspects
11694165
2001
11
05
2001
12
28
2006
11
07
0098-7484
286
17
2001
Nov
7
JAMA : the journal of the American Medical Association
JAMA
msJAMA: Breast reconstruction: one woman's choice.
2163
Bily
L
L
eng
Journal Article
United States
JAMA
7501160
0098-7484
AIM
IM
Body Image
Decision Making
Female
Humans
Mammaplasty
methods
psychology
Mastectomy
psychology
11704686
2001
11
19
2001
12
28
2005
11
16
0028-4793
345
22
2001
Nov
29
The New England journal of medicine
N. Engl. J. Med.
Recognition and management of anthrax--an update.
1621-6
Department of Medicine, Massachusetts General Hospital, Boston 02114-2696, USA.
Swartz
M N
MN
eng
Journal Article
Review
2001
11
06
United States
N Engl J Med
0255562
0028-4793
0
Anthrax Vaccines
0
Penicillins
AIM
IM
N Engl J Med. 2002 Mar 21;346(12):943-5; discusson 943-5
11911137
N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5
11907299
N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5
11911138
N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5
11911136
N Engl J Med 2002 Feb 21;346(8):634
Anthrax
diagnosis
drug therapy
epidemiology
prevention & control
Anthrax Vaccines
Antibiotic Prophylaxis
Bacillus anthracis
pathogenicity
Bioterrorism
Diagnosis, Differential
Gastrointestinal Diseases
diagnosis
microbiology
Humans
Infection Control
methods
Laboratory Techniques and Procedures
Meningitis, Bacterial
diagnosis
microbiology
Penicillins
therapeutic use
Respiratory Tract Infections
diagnosis
drug therapy
microbiology
Skin Diseases, Bacterial
diagnosis
microbiology
Spores, Bacterial
Virulence
11
11731716
2001
12
03
2002
02
28
2005
11
16
0031-7012
64
1
2002
Jan
Pharmacology
Pharmacology
Progress in the search for ideal drugs.
1-7
The search for ideal drugs to improve patient care requires applications of modern scientific methods to both discovery and development. Using these modern methods, the pharmaceutical industry with strong academic and government collaboration has introduced in the last 25 years many new drugs that approach the ideal. After reviewing Björnsson's classification of drug action and the notion of contributory causality, this commentary defines an ideal drug from the perspectives of pharmacodynamics, pharmacokinetics, and therapeutics. Examples of new drugs for hypertension, heart disease, stroke, osteoporosis, asthma, ulcer, and migraine headaches are described. Finally, the profound implications of progress in developing ideal drugs not only for the patient but also for the academic, educational, and regulatory establishments are briefly reviewed.
Copyright 2002 S. Karger AG, Basel
Department of Medicine, Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Spector
Reynold
R
eng
Journal Article
Review
Switzerland
Pharmacology
0152016
0031-7012
0
Pharmaceutical Preparations
IM
Drug Industry
Drug Therapy
trends
Humans
Pharmaceutical Preparations
classification
Pharmacokinetics
Pharmacology
25
11748851
2001
12
18
2002
03
07
2006
11
15
1098-1004
18
6
2001
Dec
Human mutation
Hum. Mutat.
Erratum: Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome.
546-7
Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases.
Copyright 2001 Wiley-Liss, Inc.
Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk
Comeglio
P
P
Evans
A L
AL
Brice
G W
GW
Child
A H
AH
eng
Corrected and Republished Article
Journal Article
Research Support, Non-U.S. Gov't
United States
Hum Mutat
9215429
1059-7794
0
Microfilament Proteins
0
fibrillin
9007-49-2
DNA
IM
Hum Mutat. 2001 Sep;18(3):251
11524736
Adult
Base Sequence
Child, Preschool
DNA
chemistry
genetics
DNA Mutational Analysis
Female
Frameshift Mutation
Great Britain
Humans
Male
Marfan Syndrome
genetics
pathology
Microfilament Proteins
genetics
Middle Aged
Mutation
Mutation, Missense
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
11748856
2001
12
18
2002
03
07
2007
11
15
1098-1004
18
6
2001
Dec
Human mutation
Hum. Mutat.
Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain.
549
Germline mutations in the MLH1 and MSH2 genes, account for the majority of HNPCC families. We have screened such families from Spain by using DGGE analysis and subsequent direct sequencing techniques. In eight families we identified six novel MLH1 and two novel MSH2 mutations comprising one frame shift mutation (c.1420 del C), two missense mutations (L622H and R687W), two splice site mutations (c.1990-1 G>A and c.453+2 T>C and one nonsense mutation (K329X) in the MLH1 gene as well as two frame shift mutations (c.1979-1980 del AT and c.1704-1705 del AG) in the MSH2 gene. Our analysis contributes to the further characterization of the mutational spectrum of MLH1 and MSH2 genes in HNPCC families.
Copyright 2001 Wiley-Liss, Inc.
Laboratory of Molecular Oncology, San Carlos University Hospital, 28040 Madrid, Spain.
Godino
J
J
de La Hoya
M
M
Diaz-Rubio
E
E
Benito
M
M
Caldés
T
T
eng
OMIM
114500
120435
120436
600258
600259
600678
Journal Article
Research Support, Non-U.S. Gov't
United States
Hum Mutat
9215429
1059-7794
0
Adaptor Proteins, Signal Transducing
0
Carrier Proteins
0
DNA-Binding Proteins
0
MLH1 protein, human
0
Neoplasm Proteins
0
Nuclear Proteins
0
Proto-Oncogene Proteins
9007-49-2
DNA
EC 3.6.1.3
MSH2 protein, human
EC 3.6.1.3
MutS Homolog 2 Protein
IM
Adaptor Proteins, Signal Transducing
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
genetics
DNA
chemistry
genetics
DNA Mutational Analysis
DNA-Binding Proteins
Family Health
Female
Germ-Line Mutation
Humans
Male
MutS Homolog 2 Protein
Neoplasm Proteins
genetics
Nuclear Proteins
Proto-Oncogene Proteins
genetics
Spain
11885531
2002
02
05
2002
04
08
2006
11
15
0028-2200
99
7
1992
Jul
Nederlands tijdschrift voor tandheelkunde
Ned Tijdschr Tandheelkd
[Microbiological diagnostics in periodontal treatment].
245-6
Periodontal diseases are bacterial infections. The rationale for the use of microbiological diagnostics in periodontal treatment of severe periodontitis patients is discussed as well as the use of adjunct antimicrobial therapy for the elimination of specific bacterial species.
Uit de vakgroep Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam (ACTA).
de Graaff
J
J
van Winkelhoff
A J
AJ
dut
English Abstract
Journal Article
Review
Microbiologische diagnostiek in de paradontologie.
Netherlands
Ned Tijdschr Tandheelkd
0400771
0028-2200
0
Anti-Bacterial Agents
D
Actinomycetales Infections
drug therapy
Anti-Bacterial Agents
therapeutic use
Humans
Hygiene
Periodontal Diseases
diagnosis
drug therapy
microbiology
Periodontitis
diagnosis
drug therapy
microbiology
Risk Factors
6
12179763
1991
12
03
1991
12
03
2003
11
14
1226-0282
10
2
1990
Dec
Pogŏn sahoe nonjip = Journal of population, health, and social welfare
Bogeon sahoe nonjib
Recent changes in the population control policy and its future directions in Korea.
152-73
Cho
N H
NH
Seo
M H
MH
Tan
B A
BA
eng
Journal Article
KOREA, REPUBLIC OF
Bogeon sahoe nonjib
9422396
1226-0282
J
Adult
Age Factors
Aged
Asia
Birth Rate
Conservation of Natural Resources
Contraception
Delivery of Health Care
Demography
Dependency (Psychology)
Developing Countries
Economics
Employment
Environment
Family Planning Services
Far East
Fertility
Health
Health Manpower
Health Planning
Health Services
Korea
Maternal-Child Health Centers
Organization and Administration
Population
Population Characteristics
Population Density
Population Dynamics
Population Growth
Primary Health Care
Program Evaluation
Public Policy
Public Sector
Research
Social Welfare
Socioeconomic Factors
Sterilization, Reproductive
067656
00204408
The total fertility rate (TFR) in Korea decreased from 6.0 to 1.6 over the period 1960-87. A national family planning program and socioeconomic development have played roles in this decline. Should this most recent TFR prevail, the nation's population will increase to 50.2 million by 2020, shifting to negative growth thereafter. Demographic aging and labor shortages will ensue. Future population policy should consider Korea's socioeconomic conditions and its burgeoning population in relation to the available land area, and aim to maintain a minimum positive population growth rate. In this context, this paper considers future population policy directions for Korea, acknowledging that its strategies and objectives must change. Postponing reaching the goal of zero population growth rate is suggested to allow a moderate population infusion of economically active individuals. These people will help facilitate greater economic development and work to improve the quality of life in Korea. Strengthened family planning/maternal-child health programs which encourage and support temporary contraceptive methods instead of sterilization will help to achieve this goal. Improving qualitative program aspects should be the center of attention in these programs. The paper also calls upon the Korea Institute for Health and Social Affairs to strengthen its research and evaluation capabilities.
Adult
Age Factors
Aged
Asia
Birth Rate
Carrying Capacity
Contraception
Contraceptive Methods
Delivery Of Health Care
Demographic Aging
Demographic Factors
Demographic Transition
Dependency Burden
Developing Countries
Eastern Asia
Economic Development
Economic Factors
Environment
Family Planning
Family Planning Programs
Fertility
Fertility Measurements
Fertility Rate
Health
Health Services
Human Resources
Korea
Labor Force
Macroeconomic Factors
Maternal-child Health Services
Microeconomic Factors
Natural Resources
Organization And Administration
Policy
Population
Population Characteristics
Population Decrease
Population Dynamics
Population Growth
Population Policy
Population Pressure
Population Size
Primary Health Care
Program Evaluation
Programs
Public Sector
Research Methodology
Social Policy
Social Welfare
Socioeconomic Factors
Sterilization, Sexual
Total Fertility Rate--changes
Zero Population Growth
TJ: JOURNAL OF POPULATION, HEALTH AND SOCIAL WELFARE
12349809
2000
12
06
2000
12
06
2007
11
15
0251-7329
37
2
2000
UN chronicle
UN Chron
Gender and globalization. A century in retrospect.
69-70
Chinkin
C
C
eng
Journal Article
UNITED STATES
UN Chron
8305532
0251-7329
J
Economics
Evaluation Studies as Topic
Interpersonal Relations
Social Change
Socioeconomic Factors
Women's Rights
152034
00297373
In the past, power structures of the nation-State have been organized around patriarchal assumptions, granting men monopoly over power, authority, and wealth. A number of structures have been erected to achieve this imbalance, which have disguised its inequity by making it appear as natural and universal. However, with globalization, this centralization of power within the Sovereign State has been fragmented. Although globalization opens up new spaces by weakening the nation-State, subsequently making possible the undermining of traditional gender hierarchies and devising new bases for gender relations, the reality that the State is no longer the sole institution that can define identity and belonging within it has denied women the space to assert their own claims to gendered self-determination. In this regard, globalization has impacted upon gender relations in complex and contradictory ways. This paper discusses such impacts of globalization on gender relations. Overall, it has become apparent that forms of inequality still exist regardless of a State's prevailing political ideology. Their manifestations may differ, but the reality of women's subordination remains constant.
Critique
Economic Factors
Gender Issues
Gender Relations
Social Change
Socioeconomic Factors
Women's Status
World
TJ: UN CHRONICLE
11831940
2002
02
08
2002
02
25
2004
11
17
0003-9950
120
2
2002
Feb
Archives of ophthalmology
Arch. Ophthalmol.
Republication of color figures.
234-7
Dushku
Nicholas
N
John
Molykutty K
MK
Schultz
Gregory S
GS
Reid
Ted W
TW
eng
Comment
Letter
United States
Arch Ophthalmol
7706534
0003-9950
EC 3.4.24.-
Matrix Metalloproteinases
AIM
IM
Arch Ophthalmol. 2001 May;119(5):695-706
11346397
Epithelial Cells
enzymology
pathology
Fibroblasts
enzymology
pathology
Humans
Immunoenzyme Techniques
Limbus Corneae
pathology
Matrix Metalloproteinases
metabolism
Pterygium
enzymology
pathology
11838066
2002
02
12
2002
02
25
2008
11
21
0023-7205
99
3
2002
Jan
17
Läkartidningen
Lakartidningen
[Unequal distribution of health resources. Research is not supported with consideration to the global significance of the diseases].
148-9
josef.milerad@lakartidningen.se
Milerad
Josef
J
swe
Biography
Historical Article
Journal Article
Portraits
Ojämn fördelning av hälsoresurser. Forskningspengar satsas inte i proportion till sjukdomars globala betydelse.
Sweden
Lakartidningen
0027707
0023-7205
IM
Health Care Rationing
History, 20th Century
Humans
Nobel Prize
Research Support as Topic
economics
organization & administration
Sweden
United States
World Health
Varmus
Harold
H
11858276
2002
02
21
2002
03
28
2008
11
21
0094-5765
48
5-12
2001 Mar-Jun
Acta astronautica
Acta Astronaut
Phase 1 research program overview.
845-51
The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success.
c2001 AIAA. Published by Elsevier Science Ltd.
NASA Johnson Space Center, Houston, TX, USA.
Uri
J J
JJ
Lebedev
O N
ON
eng
Journal Article
England
Acta Astronaut
9890631
0094-5765
S
Biological Science Disciplines
Equipment Design
Exobiology
Extraterrestrial Environment
Humans
International Cooperation
Program Evaluation
Research
instrumentation
organization & administration
Russia
Space Flight
instrumentation
organization & administration
trends
Spacecraft
USSR
United States
United States National Aeronautics and Space Administration
organization & administration
Weightlessness
00027286
Flight Experiment
Mir Project
STS Shuttle Project
long duration
manned
short duration
11858625
2002
02
22
2002
03
06
2004
11
17
0002-838X
65
3
2002
Feb
1
American family physician
Am Fam Physician
Information from your family doctor. Exercise for the elderly.
427-8
eng
Journal Article
Patient Education Handout
United States
Am Fam Physician
1272646
0002-838X
AIM
IM
Am Fam Physician. 2002 Feb 1;65(3):419-26
11858624
Aged
Exercise
Family Practice
Health Promotion
Humans
11869993
2002
02
28
2002
03
22
2004
11
17
1052-1577
27
4
2002
Feb
Harvard health letter / from Harvard Medical School
Harv Health Lett
By the way doctor... I'm 72 and was recently told that I am losing a bit of my sight because of macular degeneration. My doctor assured me that it was progressing very slowly, but also said there wasn't really anything to do about it. But I read that zinc or vitamins might help. Should I be taking them?
8
Lee
Thomas H
TH
eng
Journal Article
United States
Harv Health Lett
9425764
1052-1577
0
Antioxidants
0
Vitamins
7440-66-6
Zinc
K
Aged
Antioxidants
therapeutic use
Drug Therapy, Combination
Humans
Macular Degeneration
prevention & control
Vitamins
therapeutic use
Zinc
therapeutic use
11876201
2002
03
04
2002
03
22
2007
11
15
1069-9422
5
3
1998
Life support & biosphere science : international journal of earth space
Life Support Biosph Sci
Consumer acceptance of vegetarian sweet potato products intended for space missions.
339-46
Sweet potato is one of the crops selected for NASA's Advanced Life Support Program for potential long-duration lunar/Mars missions. This article presents recipes of products made from sweet potato and determines the consumer acceptability of products containing from 6% to 20% sweet potato on a dry weight basis. These products were developed for use in nutritious and palatable meals for future space explorers. Sensory evaluation (appearance/color, aroma, texture, flavor/taste, and overall acceptability) studies were conducted to determine the consumer acceptability of vegetarian products made with sweet potato using panelists at NASA/Johnson Space Center in Houston, TX. None of these products including the controls, contained any ingredient of animal origin with the exception of sweet potato pie. A 9-point hedonic scale (9 being like extremely and 1 being dislike extremely) was used to evaluate 10 products and compare them to similar commercially available products used as controls. The products tested were pancakes, waffles, tortillas, bread, pie, pound cake, pasta, vegetable patties, doughnuts, and pretzels. All of the products were either liked moderately or liked slightly with the exception of the sweet potato vegetable patties, which were neither liked nor disliked. Mean comparisons of sensory scores of sweet potato recipes and their controls were accomplished by using the Student t-test. Because of their nutritional adequacy and consumer acceptability, these products are being recommended to NASA's Advanced Life Support Program for inclusion in a vegetarian menu plan designed for lunar/Mars space missions.
Center for Food and Environmental Systems for Human Exploration of Space, George Washington Carver Agricultural Experiment Station, Tuskegee University, Tuskegee, AL 36088, USA.
Wilson
C D
CD
Pace
R D
RD
Bromfield
E
E
Jones
G
G
Lu
J Y
JY
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
United States
Life Support Biosph Sci
9431217
1069-9422
S
Diet, Vegetarian
psychology
Ecological Systems, Closed
Evaluation Studies as Topic
Food Habits
psychology
Food Preferences
psychology
Food Technology
Humans
Ipomoea batatas
Life Support Systems
Menu Planning
Nutritive Value
Space Flight
United States
United States National Aeronautics and Space Administration
Weightlessness
00027330
NASA Discipline Life Support Systems
Non-NASA Center
Mortley
D G
DG
Tuskegee U, AL
Grant numbers: NCC 9-51, ALX-FS-2.
11892742
2002
03
13
2002
03
18
2009
07
23
0012-1606
242
2
2002
Feb
15
Developmental biology
Dev. Biol.
The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis.
376-87
Recent studies on the structural composition of mammalian sperm heads have shown a congregate of unidentified proteins occupying the periphery of the mammalian sperm nucleus, forming a layer of condensed cytosol. These proteins are the perinuclear theca (PT) and can be categorized into SDS-soluble and SDS-insoluble components. The present study focused on identifying the major SDS-insoluble PT protein, which we localized to the subacrosomal layer of bovine spermatozoa and cloned by immunoscreening a bull testicular cDNA library. The isolated clones encode a protein of 122 amino acids that bears 67% similarity with histone H2B and contains a predicted histone fold motif. The novel amino terminus of the protein contains a potential bipartite nuclear targeting sequence. Hence, we identified this prominent subacrosomal component as a novel H2B variant, SubH2Bv. Northern blot analyses of SubH2Bv mRNA expression showed that it is testis-specific and is also present in murid testes. Immunocytochemical analysis showed SubH2Bv intimately associates, temporally and spatially, with acrosome formation. While the molecular features of SubH2Bv are common to nuclear proteins, it is never seen developmentally within the nucleus of the spermatid. Considering its developmental and molecular characteristics, we have postulated roles of SubH2Bv in acrosome assembly and acrosome-nuclear docking.
Copyright 2001 Academic Press.
Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada, K7L 3N6.
Aul
Ritu B
RB
Oko
Richard J
RJ
eng
Corrected and Republished Article
Journal Article
Research Support, Non-U.S. Gov't
United States
Dev Biol
0372762
0012-1606
0
DNA, Complementary
0
Histones
0
RNA, Messenger
63231-63-0
RNA
IM
Dev Biol. 2001 Nov 15;239(2):376-87
11784042
Acrosome
chemistry
metabolism
ultrastructure
Amino Acid Motifs
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Blotting, Western
Cattle
DNA, Complementary
metabolism
Electrophoresis, Polyacrylamide Gel
Histones
chemistry
Immunoblotting
Immunohistochemistry
Male
Mice
Molecular Sequence Data
RNA
metabolism
RNA, Messenger
metabolism
Rats
Reverse Transcriptase Polymerase Chain Reaction
Seminiferous Epithelium
metabolism
Sequence Homology, Amino Acid
Spermatogenesis
Spermatozoa
chemistry
Testis
metabolism
11909345
2002
03
22
2002
05
16
2003
11
03
0031-9007
88
10
2002
Mar
11
Physical review letters
Phys. Rev. Lett.
Measurement of B --> K*gamma branching fractions and charge asymmetries.
101805
The branching fractions of the exclusive decays B0-->K(*0)gamma and B+-->K(*+)gamma are measured from a sample of (22.74+/-0.36)x10(6) BB decays collected with the BABAR detector at the PEP-II asymmetric e(+)e(-) collider. We find B (B0-->K(*0)gamma) = [4.23+/-0.40(stat)+/-0.22(syst)]x10(-5), B(B+-->K(*+)gamma) = [3.83+/-0.62(stat)+/-0.22(syst)]x10(-5) and constrain the CP-violating charge asymmetry to be -0.170<A(CP)(B-->K(*)gamma)<0.082 at 90% C.L.
Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France.
Aubert
B
B
Boutigny
D
D
Gaillard
J-M
JM
Hicheur
A
A
Karyotakis
Y
Y
Lees
J P
JP
Robbe
P
P
Tisserand
V
V
Palano
A
A
Chen
G P
GP
Chen
J C
JC
Qi
N D
ND
Rong
G
G
Wang
P
P
Zhu
Y S
YS
Eigen
G
G
Reinertsen
P L
PL
Stugu
B
B
Abbott
B
B
Abrams
G S
GS
Borgland
A W
AW
Breon
A B
AB
Brown
D N
DN
Button-Shafer
J
J
Cahn
R N
RN
Clark
A R
AR
Gill
M S
MS
Gritsan
A V
AV
Groysman
Y
Y
Jacobsen
R G
RG
Kadel
R W
RW
Kadyk
J
J
Kerth
L T
LT
Kluth
S
S
Kolomensky
Yu G
YG
Kral
J F
JF
LeClerc
C
C
Levi
M E
ME
Liu
T
T
Lynch
G
G
Meyer
A B
AB
Momayezi
M
M
Oddone
P J
PJ
Perazzo
A
A
Pripstein
M
M
Roe
N A
NA
Romosan
A
A
Ronan
M T
MT
Shelkov
V G
VG
Telnov
A V
AV
Wenzel
W A
WA
Zisman
M S
MS
Bright-Thomas
P G
PG
Harrison
T J
TJ
Hawkes
C M
CM
Knowles
D J
DJ
O'Neale
S W
SW
Penny
R C
RC
Watson
A T
AT
Watson
N K
NK
Deppermann
T
T
Goetzen
K
K
Koch
H
H
Krug
J
J
Kunze
M
M
Lewandowski
B
B
Peters
K
K
Schmuecker
H
H
Steinke
M
M
Andress
J C
JC
Barlow
N R
NR
Bhimji
W
W
Chevalier
N
N
Clark
P J
PJ
Cottingham
W N
WN
De Groot
N
N
Dyce
N
N
Foster
B
B
McFall
J D
JD
Wallom
D
D
Wilson
F F
FF
Abe
K
K
Hearty
C
C
Mattison
T S
TS
McKenna
J A
JA
Thiessen
D
D
Jolly
S
S
McKemey
A K
AK
Tinslay
J
J
Blinov
V E
VE
Bukin
A D
AD
Bukin
D A
DA
Buzykaev
A R
AR
Golubev
V B
VB
Ivanchenko
V N
VN
Korol
A A
AA
Kravchenko
E A
EA
Onuchin
A P
AP
Salnikov
A A
AA
Serednyakov
S I
SI
Skovpen
Yu I
YI
Telnov
V I
VI
Yushkov
A N
AN
Best
D
D
Lankford
A J
AJ
Mandelkern
M
M
McMahon
S
S
Stoker
D P
DP
Ahsan
A
A
Arisaka
K
K
Buchanan
C
C
Chun
S
S
Branson
J G
JG
MacFarlane
D B
DB
Prell
S
S
Rahatlou
Sh
Sh
Raven
G
G
Sharma
V
V
Campagnari
C
C
Dahmes
B
B
Hart
P A
PA
Kuznetsova
N
N
Levy
S L
SL
Long
O
O
Lu
A
A
Richman
J D
JD
Verkerke
W
W
Witherell
M
M
Yellin
S
S
Beringer
J
J
Dorfan
D E
DE
Eisner
A M
AM
Frey
A
A
Grillo
A A
AA
Grothe
M
M
Heusch
C A
CA
Johnson
R P
RP
Kroeger
W
W
Lockman
W S
WS
Pulliam
T
T
Sadrozinski
H
H
Schalk
T
T
Schmitz
R E
RE
Schumm
B A
BA
Seiden
A
A
Turri
M
M
Walkowiak
W
W
Williams
D C
DC
Wilson
M G
MG
Chen
E
E
Dubois-Felsmann
G P
GP
Dvoretskii
A
A
Hitlin
D G
DG
Metzler
S
S
Oyang
J
J
Porter
F C
FC
Ryd
A
A
Samuel
A
A
Weaver
M
M
Yang
S
S
Zhu
R Y
RY
Devmal
S
S
Geld
T L
TL
Jayatilleke
S
S
Mancinelli
G
G
Meadows
B T
BT
Sokoloff
M D
MD
Barillari
T
T
Bloom
P
P
Dima
M O
MO
Fahey
S
S
Ford
W T
WT
Johnson
D R
DR
Nauenberg
U
U
Olivas
A
A
Park
H
H
Rankin
P
P
Roy
J
J
Sen
S
S
Smith
J G
JG
van Hoek
W C
WC
Wagner
D L
DL
Blouw
J
J
Harton
J L
JL
Krishnamurthy
M
M
Soffer
A
A
Toki
W H
WH
Wilson
R J
RJ
Zhang
J
J
Brandt
T
T
Brose
J
J
Colberg
T
T
Dahlinger
G
G
Dickopp
M
M
Dubitzky
R S
RS
Hauke
A
A
Maly
E
E
Müller-Pfefferkorn
R
R
Otto
S
S
Schubert
K R
KR
Schwierz
R
R
Spaan
B
B
Wilden
L
L
Behr
L
L
Bernard
D
D
Bonneaud
G R
GR
Brochard
F
F
Cohen-Tanugi
J
J
Ferrag
S
S
Roussot
E
E
T'Jampens
S
S
Thiebaux
Ch
Ch
Vasileiadis
G
G
Verderi
M
M
Anjomshoaa
A
A
Bernet
R
R
Khan
A
A
Lavin
D
D
Muheim
F
F
Playfer
S
S
Swain
J E
JE
Falbo
M
M
Borean
C
C
Bozzi
C
C
Dittongo
S
S
Folegani
M
M
Piemontese
L
L
Treadwell
E
E
Anulli
F
F
Baldini-Ferroli
R
R
Calcaterra
A
A
de Sangro
R
R
Falciai
D
D
Finocchiaro
G
G
Patteri
P
P
Peruzzi
I M
IM
Piccolo
M
M
Xie
Y
Y
Zallo
A
A
Bagnasco
S
S
Buzzo
A
A
Contri
R
R
Crosetti
G
G
Fabbricatore
P
P
Farinon
S
S
Lo Vetere
M
M
Macri
M
M
Monge
M R
MR
Musenich
R
R
Pallavicini
M
M
Parodi
R
R
Passaggio
S
S
Pastore
F C
FC
Patrignani
C
C
Pia
M G
MG
Priano
C
C
Robutti
E
E
Santroni
A
A
Morii
M
M
Bartoldus
R
R
Dignan
T
T
Hamilton
R
R
Mallik
U
U
Cochran
J
J
Crawley
H B
HB
Fischer
P-A
PA
Lamsa
J
J
Meyer
W T
WT
Rosenberg
E I
EI
Benkebil
M
M
Grosdidier
G
G
Hast
C
C
Höcker
A
A
Lacker
H M
HM
Laplace
S
S
Lepeltier
V
V
Lutz
A M
AM
Plaszczynski
S
S
Schune
M H
MH
Trincaz-Duvoid
S
S
Valassi
A
A
Wormser
G
G
Bionta
R M
RM
Brigljević
V V
VV
Lange
D J
DJ
Mugge
M
M
Shi
X
X
van Bibber
K
K
Wenaus
T J
TJ
Wright
D M
DM
Wuest
C R
CR
Carroll
M
M
Fry
J R
JR
Gabathuler
E
E
Gamet
R
R
George
M
M
Kay
M
M
Payne
D J
DJ
Sloane
R J
RJ
Touramanis
C
C
Aspinwall
M L
ML
Bowerman
D A
DA
Dauncey
P D
PD
Egede
U
U
Eschrich
I
I
Gunawardane
N J W
NJ
Nash
J A
JA
Sanders
P
P
Smith
D
D
Azzopardi
D E
DE
Back
J J
JJ
Dixon
P
P
Harrison
P F
PF
Potter
R J L
RJ
Shorthouse
H W
HW
Strother
P
P
Vidal
P B
PB
Williams
M I
MI
Cowan
G
G
George
S
S
Green
M G
MG
Kurup
A
A
Marker
C E
CE
McGrath
P
P
McMahon
T R
TR
Ricciardi
S
S
Salvatore
F
F
Scott
I
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Vaitsas
G
G
Brown
D
D
Davis
C L
CL
Allison
J
J
Barlow
R J
RJ
Boyd
J T
JT
Forti
A C
AC
Fullwood
J
J
Jackson
F
F
Lafferty
G D
GD
Savvas
N
N
Simopoulos
E T
ET
Weatherall
J H
JH
Farbin
A
A
Jawahery
A
A
Lillard
V
V
Olsen
J
J
Roberts
D A
DA
Schieck
J R
JR
Blaylock
G
G
Dallapiccola
C
C
Flood
K T
KT
Hertzbach
S S
SS
Kofler
R
R
Moore
T B
TB
Staengle
H
H
Willocq
S
S
Brau
B
B
Cowan
R
R
Sciolla
G
G
Taylor
F
F
Yamamoto
R K
RK
Milek
M
M
Patel
P M
PM
Trischuk
J
J
Lanni
F
F
Palombo
F
F
Bauer
J M
JM
Booke
M
M
Cremaldi
L
L
Eschenburg
V
V
Kroeger
R
R
Reidy
J
J
Sanders
D A
DA
Summers
D J
DJ
Martin
J P
JP
Nief
J Y
JY
Seitz
R
R
Taras
P
P
Zacek
V
V
Nicholson
H
H
Sutton
C S
CS
Cartaro
C
C
Cavallo
N
N
De Nardo
G
G
Fabozzi
F
F
Gatto
C
C
Lista
L
L
Paolucci
P
P
Piccolo
D
D
Sciacca
C
C
LoSecco
J M
JM
Alsmiller
J R G
JR
Gabriel
T A
TA
Handler
T
T
Brau
J
J
Frey
R
R
Iwasaki
M
M
Sinev
N B
NB
Strom
D
D
Colecchia
F
F
Dal Corso
F
F
Dorigo
A
A
Galeazzi
F
F
Margoni
M
M
Michelon
G
G
Morandin
M
M
Posocco
M
M
Rotondo
M
M
Simonetto
F
F
Stroili
R
R
Torassa
E
E
Voci
C
C
Benayoun
M
M
Briand
H
H
Chauveau
J
J
David
P
P
de La Vaissière
Ch
Ch
Del Buono
L
L
Hamon
O
O
Le Diberder
F
F
Leruste
Ph
P
Lory
J
J
Roos
L
L
Stark
J
J
Versillé
S
S
Manfredi
P F
PF
Re
V
V
Speziali
V
V
Frank
E D
ED
Gladney
L
L
Guo
Q H
QH
Panetta
J H
JH
Angelini
C
C
Batignani
G
G
Bettarini
S
S
Bondioli
M
M
Carpinelli
M
M
Forti
F
F
Giorgi
M A
MA
Lusiani
A
A
Martinez-Vidal
F
F
Morganti
M
M
Neri
N
N
Paoloni
E
E
Rama
M
M
Rizzo
G
G
Sandrelli
F
F
Simi
G
G
Triggiani
G
G
Walsh
J
J
Haire
M
M
Judd
D
D
Paick
K
K
Turnbull
L
L
Wagoner
D E
DE
Albert
J
J
Bula
C
C
Elmer
P
P
Lu
C
C
McDonald
K T
KT
Miftakov
V
V
Schaffner
S F
SF
Smith
A J S
AJ
Tumanov
A
A
Varnes
E W
EW
Cavoto
G
G
del Re
D
D
Faccini
R
R
Ferrarotto
F
F
Ferroni
F
F
Fratini
K
K
Lamanna
E
E
Leonardi
E
E
Mazzoni
M A
MA
Morganti
S
S
Piredda
G
G
Safai Tehrani
F
F
Serra
M
M
Voena
C
C
Christ
S
S
Waldi
R
R
Adye
T
T
Franek
B
B
Geddes
N I
NI
Gopal
G P
GP
Xella
S M
SM
Aleksan
R
R
De Domenico
G
G
Emery
S
S
Gaidot
A
A
Ganzhur
S F
SF
Giraud
P-F
PF
Hamel Monchenault
G
G
Kozanecki
W
W
Langer
M
M
London
G W
GW
Mayer
B
B
Serfass
B
B
Vasseur
G
G
Yèche
Ch
Ch
Zito
M
M
Copty
N
N
Purohit
M V
MV
Singh
H
H
Yumiceva
F X
FX
Adam
I
I
Anthony
P L
PL
Aston
D
D
Baird
K
K
Berger
J P
JP
Bloom
E
E
Boyarski
A M
AM
Bulos
F
F
Calderini
G
G
Claus
R
R
Convery
M R
MR
Coupal
D P
DP
Coward
D H
DH
Dorfan
J
J
Doser
M
M
Dunwoodie
W
W
Field
R C
RC
Glanzman
T
T
Godfrey
G L
GL
Gowdy
S J
SJ
Grosso
P
P
Himel
T
T
Hryn'ova
T
T
Huffer
M E
ME
Innes
W R
WR
Jessop
C P
CP
Kelsey
M H
MH
Kim
P
P
Kocian
M L
ML
Langenegger
U
U
Leith
D W G S
DW
Luitz
S
S
Luth
V
V
Lynch
H L
HL
Marsiske
H
H
Menke
S
S
Messner
R
R
Moffeit
K C
KC
Mount
R
R
Muller
D R
DR
O'Grady
C P
CP
Perl
M
M
Petrak
S
S
Quinn
H
H
Ratcliff
B N
BN
Robertson
S H
SH
Rochester
L S
LS
Roodman
A
A
Schietinger
T
T
Schindler
R H
RH
Schwiening
J
J
Seeman
J T
JT
Serbo
V V
VV
Snyder
A
A
Soha
A
A
Spanier
S M
SM
Stelzer
J
J
Su
D
D
Sullivan
M K
MK
Tanaka
H A
HA
Va'vra
J
J
Wagner
S R
SR
Weinstein
A J R
AJ
Wienands
U
U
Wisniewski
W J
WJ
Wright
D H
DH
Young
C C
CC
Burchat
P R
PR
Cheng
C H
CH
Kirkby
D
D
Meyer
T I
TI
Roat
C
C
De Silva
A
A
Henderson
R
R
Bugg
W
W
Cohn
H
H
Weidemann
A W
AW
Izen
J M
JM
Kitayama
I
I
Lou
X C
XC
Turcotte
M
M
Bianchi
F
F
Bona
M
M
Di Girolamo
B
B
Gamba
D
D
Smol
A
A
Zanin
D
D
Bosisio
L
L
Della Ricca
G
G
Lanceri
L
L
Pompili
A
A
Poropat
P
P
Vuagnin
G
G
Panvini
R S
RS
Brown
C M
CM
Kowalewski
R
R
Roney
J M
JM
Band
H R
HR
Charles
E
E
Dasu
S
S
Di Lodovico
F
F
Eichenbaum
A M
AM
Hu
H
H
Johnson
J R
JR
Liu
R
R
Nielsen
J
J
Pan
Y
Y
Prepost
R
R
Scott
I J
IJ
Sekula
S J
SJ
von Wimmersperg-Toeller
J H
JH
Wu
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SL
Yu
Z
Z
Zobernig
H
H
Kordich
T M B
TM
Neal
H
H
BABAR Collaborations
eng
Journal Article
2002
02
26
United States
Phys Rev Lett
0401141
0031-9007
11916658
2002
03
27
2002
04
15
2007
11
15
1070-910X
9
7
2002
Mar
Harvard women's health watch
Harv Womens Health Watch
By the way, doctor. A few months ago, I was surprised to read that a new study has raised a question about the value of screening mammograms. Is that true? I thought the importance of having such mammograms was well-established. I'm 52 and have been getting annual mammograms for 10 years. Should I stop?
8
Robb-Nicholson
Celeste
C
eng
Journal Article
United States
Harv Womens Health Watch
9423147
1070-910X
K
Breast Neoplasms
mortality
radiography
Clinical Trials as Topic
standards
Female
Humans
Mammography
Middle Aged
Patient Education as Topic
Research Design
11966386
2002
04
22
2002
05
02
2007
11
15
0098-7484
287
16
2002
Apr
24
JAMA : the journal of the American Medical Association
JAMA
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
2114-9
The Bethesda 2001 Workshop was convened to evaluate and update the 1991 Bethesda System terminology for reporting the results of cervical cytology. A primary objective was to develop a new approach to broaden participation in the consensus process.
Forum groups composed of 6 to 10 individuals were responsible for developing recommendations for discussion at the workshop. Each forum group included at least 1 cytopathologist, cytotechnologist, clinician, and international representative to ensure a broad range of views and interests. More than 400 cytopathologists, cytotechnologists, histopathologists, family practitioners, gynecologists, public health physicians, epidemiologists, patient advocates, and attorneys participated in the workshop, which was convened by the National Cancer Institute and cosponsored by 44 professional societies. More than 20 countries were represented.
Literature review, expert opinion, and input from an Internet bulletin board were all considered in developing recommendations. The strength of evidence of the scientific data was considered of paramount importance.
Bethesda 2001 was a year-long iterative review process. An Internet bulletin board was used for discussion of issues and drafts of recommendations. More than 1000 comments were posted to the bulletin board over the course of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to the public. Postworkshop recommendations were posted on the bulletin board for a last round of critical review prior to finalizing the terminology.
Bethesda 2001 was developed with broad participation in the consensus process. The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.
EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA. ds87v@nih.gov
Solomon
Diane
D
Davey
Diane
D
Kurman
Robert
R
Moriarty
Ann
A
O'Connor
Dennis
D
Prey
Marianne
M
Raab
Stephen
S
Sherman
Mark
M
Wilbur
David
D
Wright
Thomas
T
Jr
Young
Nancy
N
Forum Group Members
Bethesda 2001 Workshop
eng
Consensus Development Conference
Consensus Development Conference, NIH
Guideline
Journal Article
Review
United States
JAMA
7501160
0098-7484
AIM
IM
JAMA. 2002 Apr 24;287(16):2140-1
11966390
Cervical Intraepithelial Neoplasia
classification
pathology
Female
Humans
Laboratories
standards
Quality Control
Terminology as Topic
Uterine Cervical Dysplasia
classification
pathology
Uterine Cervical Neoplasms
diagnosis
pathology
Vaginal Smears
classification
standards
28
11953811
2002
05
09
2002
05
24
2008
11
21
1432-2218
16
5
2002
May
Surgical endoscopy
Surg Endosc
Disruptive visions: surgeon responsibility during the era of change.
733-4
Satava
R M
RM
eng
Editorial
Germany
Surg Endosc
8806653
0930-2794
IM
Biomedical Technology
Commerce
trends
Delivery of Health Care
trends
General Surgery
standards
trends
Health Services Needs and Demand
trends
Humans
12038483
2002
05
30
2002
07
26
2008
11
21
0273-1177
26
12
2000
Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Adv Space Res
Planetary protection issues for Mars sample acquisition flight projects.
1911-6
The planned NASA sample acquisition flight missions to Mars pose several interesting planetary protection issues. In addition to the usual forward contamination procedures for the adequate protection of Mars for the sake of future missions, there are reasons to ensure that the sample is not contaminated by terrestrial microbes from the acquisition mission. Recent recommendations by the Space Studies Board (SSB) of the National Research Council (United States), would indicate that the scientific integrity of the sample is a planetary protection concern (SSB, 1997). Also, as a practical matter, a contaminated sample would interfere with the process for its release from quarantine after return for distribution to the interested scientists. These matters are discussed in terms of the first planned acquisition mission.
c2001 COSPAR Published by Elsevier Science Ltd. All rights reserved.
Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.
Barengoltz
J B
JB
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
United States
Adv Space Res
9878935
0273-1177
7722-84-1
Hydrogen Peroxide
S
Containment of Biohazards
Environmental Microbiology
Extraterrestrial Environment
Hot Temperature
Hydrogen Peroxide
Mars
Space Flight
standards
Spacecraft
Specimen Handling
Sterilization
methods
United States
United States National Aeronautics and Space Administration
standards
00027913
NASA Center JPL
NASA Discipline Exobiology
Barengoltz
J B
JB
JPL
12101218
2002
07
08
2002
08
12
2006
11
15
0021-9258
277
28
2002
Jul
12
The Journal of biological chemistry
J. Biol. Chem.
Interaction between FtsZ and FtsW of Mycobacterium tuberculosis.
24983-7
The recruitment of FtsZ to the septum and its subsequent interaction with other cell division proteins in a spatially and temporally controlled manner are the keys to bacterial cell division. In the present study, we have tested the hypothesis that FtsZ and FtsW of Mycobacterium tuberculosis could be binding partners. Using gel renaturation, pull-down, and solid-phase assays, we confirm that FtsZ and FtsW interact through their C-terminal tails, which carry extensions absent in their Escherichia coli counterparts. Crucial to these interactions is the cluster of aspartate residues Asp(367) to Asp(370) of FtsZ, which most likely interact with a cluster of positively charged residues in the C-terminal tail of FtsW. Mutations of the aspartate residues 367-370 showed that changing three aspartate residues to alanine resulted in complete loss of interaction. This is the first demonstration of the direct interaction between FtsZ and FtsW. We speculate that this interaction between FtsZ and FtsW could serve to anchor FtsZ to the membrane and link septum formation to peptidoglycan synthesis in M. tuberculosis. The findings assume particular significance in view of the global efforts to explore new targets in M. tuberculosis for chemotherapeutic intervention.
Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India.
Datta
Pratik
P
Dasgupta
Arunava
A
Bhakta
Sanjib
S
Basu
Joyoti
J
eng
Journal Article
Research Support, Non-U.S. Gov't
2002
05
06
United States
J Biol Chem
2985121R
0021-9258
0
Bacterial Proteins
0
Cytoskeletal Proteins
0
DNA Primers
0
FtsZ protein, Bacteria
0
Membrane Proteins
125724-13-2
FtsW protein, Bacteria
IM
Amino Acid Sequence
Bacterial Proteins
chemistry
metabolism
Base Sequence
Cytoskeletal Proteins
DNA Primers
Membrane Proteins
Molecular Sequence Data
Mycobacterium tuberculosis
metabolism
Protein Binding
12145319
2002
07
29
2002
09
16
2005
11
17
0021-9258
277
31
2002
Aug
2
The Journal of biological chemistry
J. Biol. Chem.
Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.
28271-9
The regulation of SNARE complex assembly likely plays an important role in governing the specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched protein, amisyn, with a tomosyn- and VAMP-like coiled-coil-forming domain that binds specifically to syntaxin 1a and syntaxin 4 both in vitro and in vivo, as assessed by co-immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments with membranes. The amisyn coil domain can form SNARE complexes of greater thermostability than can VAMP2 with syntaxin 1a and SNAP-25 in vitro, but it lacks a transmembrane anchor and so cannot act as a v-SNARE in this complex. The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles. We propose that amisyn forms nonfusogenic complexes with syntaxin 1a and SNAP-25, holding them in a conformation ready for VAMP2 to replace it to mediate the membrane fusion event, thereby contributing to the regulation of SNARE complex formation.
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5345, USA.
Scales
Suzie J
SJ
Hesser
Boris A
BA
Masuda
Esteban S
ES
Scheller
Richard H
RH
eng
GENBANK
AF391153
Journal Article
2002
05
24
United States
J Biol Chem
2985121R
0021-9258
0
Carrier Proteins
0
Membrane Proteins
0
Nerve Tissue Proteins
0
Qa-SNARE Proteins
0
Recombinant Fusion Proteins
0
SNAP25 protein, human
0
SNARE Proteins
0
STX1A protein, human
0
STXBP6 protein, human
0
Snap25 protein, rat
0
Stx1a protein, rat
0
Synaptosomal-Associated Protein 25
0
Syntaxin 1
0
Vesicular Transport Proteins
51-41-2
Norepinephrine
EC 2.5.1.18
Glutathione Transferase
IM
Amino Acid Sequence
Animals
Binding Sites
Carrier Proteins
chemistry
genetics
physiology
Exocytosis
Glutathione Transferase
genetics
Hela Cells
Humans
Kinetics
Membrane Proteins
chemistry
metabolism
physiology
Molecular Sequence Data
Nerve Tissue Proteins
chemistry
metabolism
Norepinephrine
antagonists & inhibitors
secretion
PC12 Cells
Pheochromocytoma
Protein Structure, Secondary
Qa-SNARE Proteins
Rats
Recombinant Fusion Proteins
metabolism
SNARE Proteins
Sequence Alignment
Sequence Homology, Amino Acid
Synaptosomal-Associated Protein 25
Syntaxin 1
Thermodynamics
Vesicular Transport Proteins
12159900
2002
08
03
2002
08
22
2007
11
15
0362-4331
2002
Jul
2
The New York times
NY Times (Print)
Weighing medical ethics for many years to come: a conversation with Harold Shapiro. Interview by Howard Markel.
F6
Shapiro
Harold
H
eng
Interview
Newspaper Article
United States
NY Times (Print)
9877126
0362-4331
E
Advisory Committees
Bioethical Issues
Biomedical Research
Biotechnology
Cloning, Organism
Conflict of Interest
Embryo Research
Embryo, Mammalian
cytology
Financing, Government
Health Priorities
Human Experimentation
Humans
Research Support as Topic
Stem Cells
United States
103061
VF 2.1
Bioethics and Professional Ethics
National Bioethics Advisory Commission
Popular Approach/Source
KIE Bib: bioethics
12174865
2002
08
13
2002
08
21
2004
11
17
1145-0762
11
2
2000
Jun
Journal international de bioéthique = International journal of bioethics
J Int Bioethique
Physicians' attitudes towards medical ethics issues in Turkey.
57-67
Dept. of Deontology, Faculty of Medicine, University of Ankara, Tip. Fak. Dekanligi, Morfoloji Terleskesi, Anakara, Sihhiye - 06100 Turkey.
Pelin
S S
SS
Arda
B
B
eng
Journal Article
France
J Int Bioethique
9015754
1145-0762
E
Abortion, Induced
Animal Experimentation
Animals
Attitude of Health Personnel
Bioethical Issues
Biomedical Research
Complementary Therapies
Confidentiality
Data Collection
Ethics, Medical
Ethics, Research
Euthanasia
Humans
Physician-Patient Relations
Physicians
psychology
Prejudice
Reproductive Techniques, Assisted
Truth Disclosure
Turkey
102894
Bioethics and Professional Ethics
Empirical Approach
Pelin, Serap Sahinoglu; Arda, Berna
KIE Bib: bioethics; medical ethics
12192682
2002
08
22
2002
09
09
2006
11
15
0018-9251
35
3
1999
Jul
IEEE transactions on aerospace and electronic systems
IEEE Trans Aerosp Electron Syst
Intelligent control of a planning system for astronaut training.
1055-70
This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconstrained environment. Formulating the planning problem in the domain of discrete-event systems under a unified framework such that it can be modeled, designed, and analyzed as a control system will provide a self-contained theory for such planning systems. This will also provide a means to certify various planning systems for operations in the dynamical and complex environments in space. The work presented here completes the design, development, and analysis of an intricate, large-scale, and representative mathematical formulation for intelligent control of a real planning system for Space Station crew training. This planning system has been tested and used at NASA-Johnson Space Center.
Johnson Space Center, USA.
Ortiz
J
J
Chen
G
G
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
United States
IEEE Trans Aerosp Electron Syst
9876802
0018-9251
S
Algorithms
Artificial Intelligence
Astronauts
education
Humans
Inservice Training
Space Flight
education
Spacecraft
Systems Analysis
Time Management
United States
United States National Aeronautics and Space Administration
00028138
Grant numbers: DAAG55-98-1-0198.
12211241
2002
09
03
2002
09
13
2007
03
19
1095-9203
297
5586
2002
Aug
30
Science (New York, N.Y.)
Science
Mycobacterium leprae and demyelination.
1475-6; author reply 1475-6
Ottenhoff
Tom H M
TH
eng
Comment
Letter
United States
Science
0404511
0036-8075
IM
Science. 2002 May 3;296(5569):927-31
11988579
Bacterial Adhesion
Demyelinating Diseases
immunology
microbiology
pathology
Humans
Leprosy
immunology
microbiology
pathology
Mycobacterium leprae
pathogenicity
physiology
Schwann Cells
microbiology
12211266
2002
09
03
2002
09
25
2004
11
17
1054-6863
12
1
2002
Mar
Kennedy Institute of Ethics journal
Kennedy Inst Ethics J
Public policy and the sale of human organs.
47-64
Gill and Sade, in the preceding article in this issue of the Kennedy Institute of Ethics Journal, argue that living individuals should be free from legal constraints against selling their organs. The present commentary responds to several of their claims. It explains why an analogy between kidneys and blood fails; why, as a matter of public policy, we prohibit the sale of human solid organs, yet allow the sale of blood; and why their attack on Kant's putative argument against the sale of human body parts is misplaced. Finally, it rejects the claim that the state is entitled to interfere with the actions of individuals only if such actions would harm others. We draw certain lines grounded in what Rawls has termed "public reason" beyond which we do not give effect to the autonomous self-regarding decisions of individuals. Public resistance to the sale of human body parts, no matter how voluntary or well informed, is grounded in the conviction that such a practice would diminish human dignity and our sense of solidarity. A system of organ donation, in contrast, conveys our respect for persons and honors our common humanity.
Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA.
Cohen
Cynthia B
CB
eng
Journal Article
United States
Kennedy Inst Ethics J
9109135
1054-6863
E
Blood Donors
Commodification
Ethical Analysis
Fees and Charges
Human Body
Humans
Kidney
Kidney Transplantation
economics
Living Donors
Public Policy
Tissue and Organ Procurement
economics
United States
103573
Analytical Approach
Health Care and Public Health
24 refs. 4 fn.
KIE Bib: blood donation; organ and tissue donation
12219757
2002
09
09
2002
09
13
2006
09
26
1225-505X
10
1
2001
Jun
Ŭi sahak
Uisahak
Development of neurophysiology in the early twentieth century: Charles Scott Sherrington and The Integrative action of the nervous system.
1-21
Department of the Medical History and Medical Humanities, Seoul National University College of Medicine.
Kim
O J
OJ
eng
Biography
Historical Article
Journal Article
Korea (South)
Uisahak
9605018
1225-505X
Q
Books
history
Great Britain
History, 19th Century
History, 20th Century
Neurophysiology
history
Sherrington
C S
CS
12227380
2002
09
12
2002
09
13
2004
11
17
0269-8897
15
1
2002
Mar
Science in context
Sci Context
Paracelsus, Paracelsianism, and the secularization of the worldview.
9-27
This paper examines Paracelsus and Paracelsianism in the light of the ideas of Max Weber concerning the social consequences of the Reformation, with special reference to his theories of Entzauberung and secularization. He linked these tendencies both to the rise of capitalism and the growth of experimental science. The detailed case study of Paracelsus' account of diseases linked with saints, in common with his interpretation of many other conditions, demonstrates that he self-consciously extended the boundaries of medicine and eroded the role of magic and witchcraft associated with the church. On the other hand, Paracelsus adopted the Neoplatonic worldview, was immersed in popular magic, and evolved a system of medicine that self-consciously revolved around magic. These factors seem to place a distinct limit on his role in the demystification of knowledge. However, the magic of Paracelsus entailed a decisive break with the entrenched elitist and esoteric tradition of the occultists and hermeticists. It is argued that this reconstructed magic re-establishes the credentials of Paracelsus as a significant contributor to the disenchantment and secularization of the worldview.
All Souls College, Oxford.
Webster
Charles
C
eng
Biography
Historical Article
Journal Article
England
Sci Context
8904113
0269-8897
Q
Europe
History, 17th Century
History, 20th Century
History, Early Modern 1451-1600
Magic
history
Medicine
Philosophy
history
Religion and Medicine
Sciatica
history
Paracelsus
Weber
Max
M
12230355
2002
09
16
2002
09
25
2005
11
17
1539-3704
137
6
2002
Sep
17
Annals of internal medicine
Ann. Intern. Med.
Screening for osteoporosis in postmenopausal women: recommendations and rationale.
526-8
U.S. Preventive Services Task Force
eng
Guideline
Journal Article
Practice Guideline
United States
Ann Intern Med
0372351
0003-4819
AIM
IM
Ann Intern Med. 2003 Apr 15;138(8):689; author reply 389-90
12693905
Ann Intern Med. 2002 Sep 17;137(6):I59
12230384
Age Factors
Aged
Female
Fractures, Bone
etiology
prevention & control
Humans
Mass Screening
Middle Aged
Osteoporosis, Postmenopausal
complications
diagnosis
Risk Factors
12230384
2002
09
16
2002
09
25
2005
11
17
1539-3704
137
6
2002
Sep
17
Annals of internal medicine
Ann. Intern. Med.
Summaries for patients. Screening for osteoporosis: recommendations from the U.S. Preventive Services Task Force.
I59
eng
Journal Article
Patient Education Handout
United States
Ann Intern Med
0372351
0003-4819
AIM
IM
Ann Intern Med. 2002 Sep 17;137(6):526-8
12230355
Ann Intern Med. 2002 Sep 17;137(6):529-41
12230356
Aged
Bone Density
Evidence-Based Medicine
Female
Fractures, Bone
etiology
prevention & control
Humans
Mass Screening
Middle Aged
Osteoporosis, Postmenopausal
complications
diagnosis
therapy
Risk Factors
United States
12369570
2002
10
07
2003
02
21
2008
11
21
8750-7587
93
4
2002
Oct
Journal of applied physiology (Bethesda, Md. : 1985)
J. Appl. Physiol.
Human unilateral lower limb suspension as a model for spaceflight effects on skeletal muscle.
1563-5; author reply 1565-6
Adams
Gregory R
GR
eng
Comment
Letter
United States
J Appl Physiol
8502536
0161-7567
IM
S
J Appl Physiol. 2002 Jul;93(1):354-60
12070225
Bed Rest
Humans
Immobilization
Leg
Muscle Fibers, Skeletal
physiology
Muscle, Skeletal
physiology
Space Flight
Weight-Bearing
NASA Discipline Musculoskeletal
Non-NASA Center
Flight Experiment
STS-78 Shuttle Project
manned
short duration
Adams
G R
GR
U CA, Irvine
Fitts
R H
RH
Vanderbilt U, Nashville, TN
12416895
2002
11
05
2003
04
01
2007
11
14
1528-9117
8
5
2002 Sep-Oct
Cancer journal (Sudbury, Mass.)
Cancer J
Radiotherapy alone for lymphocyte-predominant Hodgkin's disease.
377-83
The purpose of the study was to analyze the results with radiotherapy alone in a select group of asymptomatic adults with nonbulky, early-stage lymphocyte-predominant Hodgkin's disease.
Between 1963 and 1995, 36 patients with nonbulky stage IA (N = 27) or IIA (N = 9) supradiaphragmatic (N = 27) or subdiaphragmatic (N = 9) lymphocyte-predominant Hodgkin's disease were treated with radiotherapy alone. Eleven of the patients underwent laparotomy. Limited-field radiotherapy involving only one side of the diaphragm and extended-field radiotherapy encompassing both sides of the diaphragm were used in 28 and 8 cases, respectively. Median dose to involved areas was 40.0 Gy given daily in 20 2.0-Gy fractions. Salvage treatmentconsisted of MOPP (mechlorethamine, vincristine, prednisone, procarbazine), CVPP/ABDIC (cyclophosphamide, vinblastine, procarbazine and prednisone/doxorubicin, bleomycin, dacarbazine, lomustine, and prednisone), or ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy and/or involved-field radiotherapy.
Median follow-up was 8.8 years (range, 3.0-34.4 years). None of the 15 patients with supradiaphragmatic disease who received limited-field radiotherapy to regions that did not include the mediastinal or hilar nodes subsequently experienced relapse there. Only one of 20 patients who received supradiaphragmatic limited-field radiotherapy alone experienced relapse in the paraaortic nodes or spleen. The 5-year relapse-free and overall survival rates for the 20 patients with stage IA lymphocyte-predominant Hodgkin's disease treated with involved-field or regional radiotherapy were 95% and 100%, respectively. There were no cases of severe or life-threatening cardiac toxicity. No solid tumors have been observed in-field in patients treated with limited-field radiotherapy, even though they have been followed up longer than those treated with extended-field radiotherapy (median follow-up, 11.6 vs 5.5 years); two solid tumors have developed in-field in patients who received extended-field radiotherapy.
Involved-field or regional radiotherapy alone may be adequate in stage IA lymphocyte-predominant Hodgkin's disease patients. Longer follow-up will help to more clearly define the risks of cardiac toxicity and solid tumors that result from involved-field or regional radiotherapy, which appear to be low based on follow-up to date.
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA.
Schlembach
Pamela J
PJ
Wilder
Richard B
RB
Jones
Dan
D
Ha
Chul S
CS
Fayad
Luis E
LE
Younes
Anas
A
Hagemeister
Fredrick
F
Hess
Mark
M
Cabanillas
Fernando
F
Cox
James D
JD
eng
CA 16672
CA
NCI NIH HHS
United States
CA 6294
CA
NCI NIH HHS
United States
Journal Article
Research Support, U.S. Gov't, P.H.S.
United States
Cancer J
100931981
1528-9117
11056-06-7
Bleomycin
13010-47-4
Lomustine
23214-92-8
Doxorubicin
4342-03-4
Dacarbazine
51-75-2
Mechlorethamine
53-03-2
Prednisone
57-22-7
Vincristine
671-16-9
Procarbazine
865-21-4
Vinblastine
ABDIC protocol
ABVD protocol
CVPP protocol
MOPP protocol
IM
Cancer J. 2002 Sep-Oct;8(5):367-8
12416892
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols
administration & dosage
therapeutic use
Bleomycin
administration & dosage
Combined Modality Therapy
Dacarbazine
administration & dosage
Doxorubicin
administration & dosage
Female
Hodgkin Disease
drug therapy
radiotherapy
Humans
Lomustine
administration & dosage
Male
Mechlorethamine
administration & dosage
Middle Aged
Prednisone
administration & dosage
Procarbazine
administration & dosage
Radiotherapy Dosage
Retrospective Studies
Salvage Therapy
methods
Survival Analysis
Treatment Outcome
Vinblastine
administration & dosage
Vincristine
administration & dosage
12501715
2002
12
27
2003
01
08
2005
11
16
0559-7765
29
1
1998
Jan
Sheng li ke xue jin zhan [Progress in physiology]
Sheng Li Ke Xue Jin Zhan
[Mechanism of bone mineral loss in microgravity].
84-6
Cui
W
W
chi
Journal Article
Review
China
Sheng Li Ke Xue Jin Zhan
20730140R
0559-7765
IM
S
Bone Demineralization, Pathologic
etiology
Humans
Space Flight
Weightlessness
adverse effects
Weightlessness Simulation
adverse effects
10
Cosmos 1129 Project
Cosmos 2044 Project
Flight Experiment
STS-51B Shuttle Project
STS-54 Shuttle Project
manned
short duration
unmanned
12599353
2003
02
24
2003
03
10
2007
11
15
0025-4282
53
4
1994
Maryland law review (Baltimore, Md. : 1936)
MD Law Rev
The new Uniform Health Care Decisions Act: paving a health care decisions superhighway?
1238-54
American Bar Association, Commission on Legal Problems of the Elderly, USA.
Sabatino
C P
CP
eng
Journal Article
United States
MD Law Rev
100971842
0025-4282
E
Advance Directives
legislation & jurisprudence
Decision Making
Humans
Legislation, Medical
Life Support Care
Personal Autonomy
Proxy
legislation & jurisprudence
Records as Topic
United States
106309
Special Issue
Death and Euthanasia
Legal Approach
Uniform Health-Care Decisions Act
Uniform Rights of the Terminally Ill Act
Sabatino, Charles P
102 fn.
KIE Bib: advance directives
12599354
2003
02
24
2003
03
10
2004
11
17
0025-4282
53
4
1994
Maryland law review (Baltimore, Md. : 1936)
MD Law Rev
The right to refuse life-sustaining medical treatment: national trend and recent changes in Maryland law.
1306-43
Goldmeier
K E
KE
eng
Journal Article
United States
MD Law Rev
100971842
0025-4282
E
Decision Making
Euthanasia, Passive
legislation & jurisprudence
Family
psychology
Humans
Legal Guardians
legislation & jurisprudence
Life Support Care
Maryland
Persistent Vegetative State
Right to Die
legislation & jurisprudence
Treatment Refusal
legislation & jurisprudence
United States
106310
Special Issue
Death and Euthanasia
Legal Approach
Mack v. Mack
Goldmeier, Karen E
235 fn.
KIE Bib: allowing to die/legal aspects; treatment refusal
12742516
2003
05
13
2009
02
27
1879-0712
468
2
2003
May
9
European journal of pharmacology
Eur. J. Pharmacol.
S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties.
93-101
Mitochondrial Ca(2+) accumulation can induce a sudden increase in the permeability of the inner membrane. This phenomenon is due to the generation of a large nonselective ion channel, termed the permeability transition pore (PTP), which contributes to cellular injury during ischemia and reperfusion. Inhibition of PTP generation constitutes a relevant pharmacological target to protect a cell from death. In this study, we examined the effect of S-15176 ((N-[(3,5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3,4-trimethoxybenzyl)piperazine), a novel anti-ischemic agent, on PTP in rat liver mitochondria. S-15176 prevented PTP opening generated by various triggering agents, as attested by the concentration-dependent inhibition of mitochondrial swelling, of mitochondrial membrane potential dissipation and of NADPH oxidation. These effects were associated with an increase in the Ca(2+) loading capacity of mitochondria. S-15176 was a strong inhibitor of lipid peroxidation, but experiments with another trimetazidine derivative devoid of antioxidant activity indicated that this activity was not essential to the inhibitory effect. Binding studies demonstrated that [3H]S-15176 bound to mitochondrial binding sites, especially those localized in the inner membrane. These sites were shared by several well-known inhibitors of PTP opening. These results demonstrate that the mechanism by which S-15176 protects mitochondria against the deleterious effects of ischemia-reperfusion involves inhibition of PTP opening and provide evidence that the drug operates through low structural specificity binding sites located in the inner mitochondrial membrane.
Département de Pharmacologie, Faculté de Médecine de Paris XII, Créteil, France
Elimadi
Aziz
A
Jullien
Vincent
V
Tillement
Jean Paul
JP
Morin
Didier
D
eng
Journal Article
Research Support, Non-U.S. Gov't
Netherlands
Eur J Pharmacol
1254354
0014-2999
0
Antioxidants
0
Mitochondrial Membrane Transport Proteins
0
Piperazines
0
S 15176
0
mitochondrial permeability transition pore
53-59-8
NADP
7440-70-2
Calcium
IM
Animals
Antioxidants
pharmacology
Binding Sites
Calcium
metabolism
Lipid Peroxidation
drug effects
Male
Membrane Potential, Mitochondrial
drug effects
Mitochondria, Liver
drug effects
metabolism
Mitochondrial Membrane Transport Proteins
drug effects
metabolism
NADP
metabolism
Oxidation-Reduction
Piperazines
pharmacology
Rats
Rats, Wistar
12742518
2003
05
13
2009
02
27
1879-0712
468
2
2003
May
9
European journal of pharmacology
Eur. J. Pharmacol.
Behavioral effects of rimcazole analogues alone and in combination with cocaine.
109-19
Several sigma receptor ligands have been reported to also have affinity for the dopamine transporter, among them rimcazole (9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride). However, rimcazole lacks behavioral effects like those of other dopamine uptake inhibitors, such as cocaine and GBR 12909 (1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride). Because of this profile, the interactions with cocaine of rimcazole and several of its novel analogues were assessed. The compounds studied were rimcazole, its N-methyl analogue, SH 1-73 (9-[3-(cis-3,5-dimethyl-4-methyl-1-piperazinyl)-propyl]carbazole hydrobromide), the dibrominated analogue, SH 1-76 (3,6-dibromo-9-[3-(cis-3,5-dimethyl-1-piperazinyl)-propyl]carbazole hydrochloride), and the N-propylphenyl analogues, SH 3-24 ([3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]diphenylamine hydrochloride) and SH 3-28 (9-[3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]carbazole hydrobromide). The former has a diphenyl-amine group in place of the carbazole moiety of rimcazole, giving the compound additional structural similarity to GBR 12909. The rimcazole analogues produced dose-related decreases in locomotor activity, and also decreased cocaine-stimulated activity in mice. In rats trained to discriminate 10 mg/kg cocaine (i.p.) from saline injections, cocaine and GBR 12909 each produced a dose-related increase in cocaine-appropriate responding. Cocaine also increased rates of responding. SH 3-28 decreased cocaine-appropriate responding at the cocaine training dose to about 58% (SH 3-28) with two of five subjects selecting the cocaine response key. Neither rimcazole nor SH 3-24 produced a significant attenuation of the discriminative effects of cocaine. Rimcazole and its analogs all attenuated the increases in rates of responding produced by cocaine. In contrast to effects obtained with rimcazole analogs, GBR 12909 potentiated the cocaine-induced increases in locomotor activity and operant behavior, as well as the discriminative-stimulus effects of cocaine. The present results indicate that analogues of rimcazole can attenuate the behavioral effects of cocaine, and though the mechanism for these effects is not presently clear, it is possible that this attenuation maybe mediated by actions of the rimcazole analogues at the dopamine transporter and/or sigma receptors.
Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. jkatz@intra.nida.nih.gov
Katz
Jonathan L
JL
Libby
Therissa A
TA
Kopajtic
Theresa
T
Husbands
Stephen M
SM
Newman
Amy Hauck
AH
eng
Journal Article
Research Support, N.I.H., Extramural
Netherlands
Eur J Pharmacol
1254354
0014-2999
0
Carbazoles
0
Dopamine Plasma Membrane Transport Proteins
0
Dopamine Uptake Inhibitors
0
Receptors, sigma
50-36-2
Cocaine
75859-04-0
rimcazole
IM
Animals
Behavior, Animal
drug effects
Carbazoles
administration & dosage
agonists
pharmacology
Cocaine
administration & dosage
pharmacology
Conditioning, Operant
drug effects
Dopamine Plasma Membrane Transport Proteins
drug effects
metabolism
Dopamine Uptake Inhibitors
administration & dosage
pharmacology
Dose-Response Relationship, Drug
Male
Mice
Motor Activity
drug effects
Rats
Rats, Sprague-Dawley
Receptors, sigma
drug effects
metabolism
Structure-Activity Relationship
12742519
2003
05
13
2009
02
27
2010
11
18
1879-0712
468
2
2003
May
9
European journal of pharmacology
Eur. J. Pharmacol.
Risperidone reduces limited access alcohol drinking in alcohol-preferring rats.
121-7
An atypical antipsychotic drug risperidone reduced ethanol drinking of ethanol-preferring Alko, Alcohol (AA) rats in a limited access paradigm. Its effect was transient at a dose known to preferentially antagonize the 5-HT(2) receptors (0.1 mg/kg, s.c.), but long-lasting when the dose was increased to 1.0 mg/kg that also blocks dopamine D(2) receptors. Risperidone also reduced dose-dependently locomotor activity and limited access saccharin intake of the AA rats, indicating that its effect on ethanol drinking was not selective. Risperidone at 0.1 mg/kg given before four successive daily ethanol-drinking sessions significantly reduced the ethanol intake. These data from an animal model of high ethanol intake suggest that risperidone should be tested in various populations of alcoholics for reducing ethanol consumption.
Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
Ingman
Kimmo
K
Honkanen
Aapo
A
Hyytiä
Petri
P
Huttunen
Matti O
MO
Korpi
Esa R
ER
eng
Journal Article
Research Support, Non-U.S. Gov't
Netherlands
Eur J Pharmacol
1254354
0014-2999
0
Antipsychotic Agents
0
Receptors, Dopamine D2
0
Serotonin 5-HT2 Receptor Antagonists
106266-06-2
Risperidone
81-07-2
Saccharin
IM
Alcohol Drinking
prevention & control
Alcoholism
drug therapy
Animals
Antipsychotic Agents
administration & dosage
pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Male
Motor Activity
drug effects
Rats
Receptors, Dopamine D2
antagonists & inhibitors
Risperidone
administration & dosage
pharmacology
Saccharin
Self Administration
Serotonin 5-HT2 Receptor Antagonists
14594616
2003
11
03
2004
02
02
2004
11
17
1087-2108
9
4
2003
Oct
Dermatology online journal
Dermatol. Online J.
Epidermal nevus.
43
A 20-year-old woman presented with an asymptomatic, life-long, verrucous, hyperpigmented plaque on the face and neck that corresponded to the lines of Blaschko. Histopathologic examination shows an epidermal nevus. This nevus presents a challenge in management because of the location and extent of the lesion.
Ronald O. Perelman Department of Dermatology, New York University, USA.
Cassetty
Christopher T
CT
Leonard
Aimee L
AL
eng
Case Reports
Journal Article
United States
Dermatol Online J
9610776
1087-2108
IM
Adult
Facial Neoplasms
pathology
therapy
Female
Humans
Nevus
pathology
therapy
Skin Neoplasms
pathology
therapy
14668029
2003
12
11
1024-5332
8
6
2003
Dec
Hematology (Amsterdam, Netherlands)
Hematology
Clopidogrel: Interactions with the P2Y12 Receptor and Clinical Relevance.
359-65
Dorsam
Robert T
RT
Murugappan
Swaminathan
S
Ding
Zhongren
Z
Kunapuli
Satya P
SP
eng
Journal Article
England
Hematology
9708388
1024-5332
IM
14668030
2003
12
11
1024-5332
8
6
2003
Dec
Hematology (Amsterdam, Netherlands)
Hematology
Platelet counts and interleukin-6 (IL-6) promoter polymorphism in patients with Gaucher disease.
367-8
Elstein
Deborah
D
Altarescu
Gheona
G
Zimran
Ari
A
eng
Journal Article
England
Hematology
9708388
1024-5332
IM
14695699
2003
12
26
2005
04
12
2006
11
15
1226-0479
9
4
2003
Dec
Taehan Kan Hakhoe chi = The Korean journal of hepatology
Taehan Kan Hakhoe Chi
[The significance of urine sodium measurement after furosemide administration in diuretics-unresponsive patients with liver cirrhosis].
324-31
The diagnosis of refractory ascites means a poor prognosis for patients with liver cirrhosis. The definition of refractory ascites has already been established, but using the dosage of diuretics that correlates with the definition of refractory ascites in an out-patient department will lower the compliance of the patient, as well as causing serious complications, such as hepatic encephalopathy and hyponatremia, as the dosage of diuretics is increased. Due to this fact, it is very difficult to apply this definition of refractory ascites to patients in a domestic out-patient department. In this study, in situations where there are difficulties in applying the diuretics dosage according to definition of refractory ascites, we tried to find out whether measuring the value of urine sodium after the administration of intravenous furosemide can be the standard in early differentiation of the response to diuretics treatment.
We reviewed 16 cases of liver cirrhosis with ascites and classified them into two groups by the response to diuretics. The diuretics-responsive ascites group was 8 cases and the diuretics-unresponsive ascites group consisted of 8 cases. After admission, we examined the patients' CBC, biochemical liver function test, spot urine sodium, and 24 hour creatinine clearance. After the beginning of the experiment, all diuretic therapy was stopped for 3 days. Daily we examined the patients' CBC, biochemical liver function test, and in the 3rd experiment day, we measured 24-hour urine volume and sodium. In the 4th experiment day, after sampling for ADH, plasma renin activity and plasma aldosterone level, we administrated the furosemide 80 mg I.V, and measured the amount of 8 hour urine volume and sodium.
The plasma aldosterone level was significantly higher in the diuretics- unresponsive ascites group than in the diuretics-responsive ascites group. In the 4th experiment day, the amount of urine volume and sodium was very significantly lower in the diuretics-unresponsive ascites group than in the diuretics-responsive ascites group (1297.5 +/-80.9 vs 2003.7 +/-114.6 ml, p<0.005, 77.3 +/-8.2 vs 211.8 +/-12.6 mEq, p<0.001).
In out-patient departments, the measurement of urine sodium 8 hours after administrating 80 mg of intravenous furosemide, will help in differentiating ascites patients with lower treatment response to diuretics.
Research Institute of Digestive Disease, Hanyang University College of Medicine, Seoul, Korea.
Cho
Hyun Seok
HS
Park
Geun Tae
GT
Kim
Young Hoon
YH
Shim
Sung Gon
SG
Kim
Jin Bae
JB
Lee
Oh Young
OY
Choi
Ho Soon
HS
Hahm
Joon Soo
JS
Lee
Min Ho
MH
kor
English Abstract
Journal Article
Korea (South)
Taehan Kan Hakhoe Chi
9607534
1226-0479
0
Diuretics
54-31-9
Furosemide
7440-23-5
Sodium
IM
Adult
Aged
Ascites
drug therapy
etiology
urine
Diuretics
administration & dosage
Female
Furosemide
administration & dosage
Humans
Infusions, Intravenous
Liver Cirrhosis
complications
Male
Middle Aged
Sodium
urine
14729922
2004
01
19
2004
02
11
2009
11
18
1362-4962
32
1
2004
Nucleic acids research
Nucleic Acids Res.
Local homology recognition and distance measures in linear time using compressed amino acid alphabets.
380-5
Methods for discovery of local similarities and estimation of evolutionary distance by identifying k-mers (contiguous subsequences of length k) common to two sequences are described. Given unaligned sequences of length L, these methods have O(L) time complexity. The ability of compressed amino acid alphabets to extend these techniques to distantly related proteins was investigated. The performance of these algorithms was evaluated for different alphabets and choices of k using a test set of 1848 pairs of structurally alignable sequences selected from the FSSP database. Distance measures derived from k-mer counting were found to correlate well with percentage identity derived from sequence alignments. Compressed alphabets were seen to improve performance in local similarity discovery, but no evidence was found of improvements when applied to distance estimates. The performance of our local similarity discovery method was compared with the fast Fourier transform (FFT) used in MAFFT, which has O(L log L) time complexity. The method for achieving comparable coverage to FFT is revealed here, and is more than an order of magnitude faster. We suggest using k-mer distance for fast, approximate phylogenetic tree construction, and show that a speed improvement of more than three orders of magnitude can be achieved relative to standard distance methods, which require alignments.
bob@drive5.com
Edgar
Robert C
RC
eng
Journal Article
2004
01
16
England
Nucleic Acids Res
0411011
0305-1048
0
Amino Acids
0
Proteins
IM
Proteins. 2000 Feb 1;38(2):149-64
10656262
J Mol Biol. 2003 Feb 7;326(1):317-36
12547212
Mol Biol Evol. 2002 Jan;19(1):8-13
11752185
Nucleic Acids Res. 2002 Jul 15;30(14):3059-66
12136088
Nucleic Acids Res. 1998 Jan 1;26(1):316-9
9399863
Bioinformatics. 2003 Mar 1;19(4):513-23
12611807
Protein Eng. 2003 May;16(5):323-30
12826723
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10915-9
1438297
Comput Appl Biosci. 1992 Jun;8(3):275-82
1633570
J Mol Biol. 1991 Jun 5;219(3):555-65
2051488
J Mol Biol. 1990 Oct 5;215(3):403-10
2231712
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8
3162770
Mol Biol Evol. 1987 Jul;4(4):406-25
3447015
J Theor Biol. 1986 Mar 21;119(2):205-18
3461222
Nucleic Acids Res. 1994 Nov 11;22(22):4673-80
7984417
Proc Int Conf Intell Syst Mol Biol. 1996;4:230-40
8877523
Protein Eng. 2000 Mar;13(3):149-52
10775656
Algorithms
Amino Acids
analysis
Computational Biology
methods
Evolution, Molecular
Molecular Sequence Data
Phylogeny
Proteins
chemistry
Sequence Alignment
methods
Sequence Homology, Amino Acid
Software
Time Factors
PMC373290
14744982
2004
01
27
2004
02
02
2009
11
18
1362-4962
32
1
2004
Nucleic acids research
Nucleic Acids Res.
Superior 5' homogeneity of RNA from ATP-initiated transcription under the T7 phi 2.5 promoter.
e14
Transcription from the commonly used GTP- initiating T7 class III promoter phi6.5 frequently produces heterogeneous RNA at both 3' and 5' ends. We demonstrate here that RNA transcripts from the T7 class II promoter phi2.5 have superior 5' homogeneity over those from the phi6.5 promoter, with comparable total RNA yields. The overall homogeneity of RNA transcripts is improved to different degrees depending on RNA sequences, although transcription under phi2.5 does not affect the 3' heterogeneity of RNA. In combination with 3' RNA trimming by DNAzymes or ribozymes, this ATP- initiated transcription system based on the T7 phi2.5 promoter can provide excellent quality of RNA for applications requiring a high degree of RNA size homogeneity.
Department of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406-5043, USA.
Coleman
Tricia M
TM
Wang
Guocan
G
Huang
Faqing
F
eng
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
2004
01
15
England
Nucleic Acids Res
0411011
0305-1048
0
3' Untranslated Regions
0
5' Untranslated Regions
0
RNA, Viral
56-65-5
Adenosine Triphosphate
IM
RNA. 1999 May;5(5):618-21
10334331
RNA. 1999 Sep;5(9):1268-72
10496227
Curr Opin Struct Biol. 2000 Jun;10(3):298-302
10851189
Biochemistry. 2000 Dec 19;39(50):15548-55
11112541
Methods. 2001 Mar;23(3):201-5
11243833
Nucleic Acids Res. 2002 Jun 15;30(12):e56
12060694
Chem Biol. 2002 Nov;9(11):1227-36
12445773
Methods Enzymol. 1995;261:350-80
8569503
Methods Enzymol. 1995;261:300-22
8569501
Nature. 1994 Nov 3;372(6501):68-74
7969422
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3680-4
7682716
J Mol Biol. 1995 Jun 2;249(2):398-408
7540213
Science. 1998 Oct 9;282(5387):259-64
9841391
RNA. 1998 Oct;4(10):1313-7
9769105
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4262-6
9113977
Science. 1996 Sep 20;273(5282):1678-85
8781224
Nucleic Acids Res. 1996 Mar 1;24(5):977-8
8600468
Nucleic Acids Res. 2003 Feb 1;31(3):e8
12560511
Nucleic Acids Res. 2003 Aug 1;31(15):e82
12888534
Nature. 1992 Jan 9;355(6356):184-6
1370345
Nucleic Acids Res. 1992 Sep 11;20(17):4515-23
1383928
RNA. 2003 Dec;9(12):1562-70
14624011
J Biol Chem. 1988 Dec 5;263(34):18123-7
3192528
Nucleic Acids Res. 1987 Nov 11;15(21):8783-98
3684574
J Mol Biol. 1983 Jun 5;166(4):477-535
6864790
3' Untranslated Regions
genetics
metabolism
5' Untranslated Regions
genetics
metabolism
Adenosine Triphosphate
metabolism
pharmacology
Bacteriophage T7
genetics
Base Sequence
Gene Expression Regulation, Viral
Molecular Sequence Data
Molecular Weight
Promoter Regions, Genetic
genetics
RNA, Viral
chemistry
genetics
metabolism
Transcription, Genetic
drug effects
PMC373309
14749521
2004
01
29
2004
02
23
2004
11
17
1539-6150
2004
4
2004
Jan
28
Science of aging knowledge environment : SAGE KE
Sci Aging Knowledge Environ
Hampering a heartbreaker. Antibiotic might stem injury from heart attack.
nf13
A TV ad urges people who think they're having a heart attack to pop an aspirin before rushing to the emergency room. They might be even better off taking antibiotics, according to a new study. The work shows that an antibiotic stems a previously untreatable form of heart damage not by killing bugs but by suppressing cellular enzymes.
Leslie
Mitch
M
eng
News
2004
01
28
United States
Sci Aging Knowledge Environ
101146039
1539-6150
0
Enzyme Inhibitors
56-75-7
Chloramphenicol
IM
Animals
Chloramphenicol
therapeutic use
Enzyme Inhibitors
therapeutic use
Humans
Myocardial Infarction
enzymology
prevention & control
Myocardial Ischemia
enzymology
prevention & control
Myocardial Reperfusion Injury
enzymology
prevention & control
Rats
14991249
2004
04
16
2005
03
15
0364-2348
33
5
2004
May
Skeletal radiology
Skeletal Radiol.
Spontaneous resolution of solitary osteochondroma in the young adult.
303-5
Spontaneous resolution of a solitary osteochondroma is rare. Such a case is presented in a patient nearing skeletal maturity. Based on a search of the English literature this is the first such report in a patient of this age.
Department of Orthopaedics, Queen Alexandra Hospital, Portsmouth, UK.
Reston
S C
SC
Savva
N
N
Richards
R H
RH
eng
Case Reports
Journal Article
2004
02
26
Germany
Skeletal Radiol
7701953
0364-2348
IM
Adolescent
Bone Neoplasms
diagnosis
Femur
radiography
Follow-Up Studies
Humans
Male
Osteochondroma
diagnosis
Remission, Spontaneous
11431089
2004
04
20
2005
06
08
0924-7947
7
2001
Archives of gerontology and geriatrics. Supplement
Arch Gerontol Geriatr Suppl
An investigation on behavioral problems in centenarians.
375-8
Department of Aging Science, Policlinico Umberto I, University La Sapienza, Roma, Italy.
Tafaro
L
L
Cicconetti
P
P
Martella
S
S
Tedeschi
G
G
Zannino
G
G
Troisi
G
G
Pastena
I
I
Fioravanti
M
M
Marigliano
V
V
eng
Journal Article
Ireland
Arch Gerontol Geriatr Suppl
8911786
0924-7947
15110832
2004
04
27
2004
12
10
2006
11
15
0968-0896
12
10
2004
May
15
Bioorganic & medicinal chemistry
Bioorg. Med. Chem.
Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage.
2509-15
Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N*) and iminyl (R2C=N*) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350 nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular phiX174 RFI DNA at pH 6.0 resulted in single-strand cleavage of DNA. Attachment of the electron-donating OMe group to arylhydrazones increased their DNA-cleaving activity. Results from systematic studies indicate that both the aminyl and the iminyl radicals possessed DNA-cleaving ability.
Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan, ROC. jrhwu@mx.nthu.edu.tw
Hwu
Jih Ru
JR
Lin
Chun Chieh
CC
Chuang
Shih Hsien
SH
King
Ke Yung
KY
Su
Tzu-Rong
TR
Tsay
Shwu-Chen
SC
eng
Journal Article
Research Support, Non-U.S. Gov't
England
Bioorg Med Chem
9413298
0968-0896
0
Hydrazones
IM
DNA Damage
Hydrazones
chemical synthesis
chemistry
Molecular Structure
Photolysis
15117668
2004
04
30
2004
05
10
0022-2895
22
3
1990
Sep
Journal of motor behavior
J Mot Behav
The First Conference on Motor Control in Down Syndrome.
444-6
Latash
M L
ML
eng
Journal Article
United States
J Mot Behav
0236512
0022-2895
15206831
2004
06
21
2004
07
29
2007
11
14
0896-4289
29
3
2003
Fall
Behavioral medicine (Washington, D.C.)
Behav Med
Warm partner contact is related to lower cardiovascular reactivity.
123-30
The authors investigated the relationship between brief warm social and physical contact among cohabitating couples and blood pressure (BP) reactivity to stress in a sample of healthy adults (66 African American, 117 Caucasian; 74 women, 109 men). Prior to stress, the warm contact group underwent a 10-minute period of handholding while viewing a romantic video. Followed by a 20-second hug with their partner, while the no contact group rested quietly for 10 minutes and 20 seconds. In response to a public speaking task, individuals receiving prestress partner contact demonstrated lower systolic BP diastolic BP, and heart rate increases compared with the no contact group. The effects of warm contact were comparable for men and women and were greater for African Americans compared with Caucasians. These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health.
Department of Psychiatry, University of North Carolina at Chapel Hill, 27599-7175, USA. karen_grewen@med.unc.edu
Grewen
Karen M
KM
Anderson
Bobbi J
BJ
Girdler
Susan S
SS
Light
Kathleen C
KC
eng
HL64927
HL
NHLBI NIH HHS
United States
RR00046
RR
NCRR NIH HHS
United States
Journal Article
Research Support, U.S. Gov't, P.H.S.
United States
Behav Med
8804264
0896-4289
IM
Adult
Affect
Blood Pressure
physiology
Body Temperature
Female
Heart Rate
physiology
Humans
Life Change Events
Male
Marriage
psychology
Middle Aged
Speech
Spouses
Touch
15228064
2004
07
01
2004
08
06
2005
11
16
1080-6032
15
2
2004
Summer
Wilderness & environmental medicine
Wilderness Environ Med
Acute coronary ischemia following centipede envenomation: case report and review of the literature.
109-12
This is the first known case report of electrocardiographic (ECG) changes suggestive of coronary vasospasm following a centipede envenomation. A 60-year-old man presented to the emergency department (ED) 1 hour after being stung by a 12-cm centipede. He complained of right great toe pain that did not radiate to his leg. The patient had no known ischemic heart disease. He did not describe any exertional symptoms but admitted experiencing weakness. During the ED course, concurrent with obtaining peripheral intravenous access, the patient experienced diaphoresis, dizziness, hypotension, and bradycardia. His ECG showed new ST-T wave changes, which suggested an acute ischemic process. The patient's blood pressure was 89/60 mm Hg, his pulse rate was 47 beats/min, and his respiration rate was 28 breaths/min. In the following hours, ECG findings returned to baseline. His blood pressure improved gradually with fluid resuscitation after approximately 5 hours. Cardiac markers returned to normal in the 13th hour after the event, and the patient underwent exercise stress testing, which was negative. The patient was discharged with cardiology follow-up. Adult patients with centipede envenomation should be closely monitored in anticipation of possible myocardial ischemia due to vasospasm, hypotension, and myocardial toxic effects of the venom. A child receiving the same amount of venom would be potentially at greater risk.
Dokuz Eylul University School of Medicine, Department of Emergency Medicine, Inciralti, Izmir, Turkey. mozsarac@hotmail.com
Ozsarac
Murat
M
Karcioglu
Ozgur
O
Ayrik
Cuneyt
C
Somuncu
Fatih
F
Gumrukcu
Serhat
S
eng
Case Reports
Journal Article
Review
United States
Wilderness Environ Med
9505185
1080-6032
IM
Animals
Arachnidism
complications
diagnosis
therapy
Arthropods
Diagnosis, Differential
Electrocardiography
Emergency Treatment
Humans
Male
Middle Aged
Myocardial Ischemia
complications
diagnosis
therapy
18
15278624
2004
07
27
2005
02
07
2009
11
03
0913-8668
5
3
1991
Jul
Journal of anesthesia
J Anesth
Hypoxic ventilatory response in cats lightly anesthetized with ketamine: effects of halothane and sevoflurane in low concentrations.
233-8
The effect of low concentration sevoflurane and halothane on the ventilatory response to isocapnic hypoxia was studied in sixteen cats. The cats were divided into two groups, sevoflurane group and halothane group, of eight subjects each. As parameters of the hypoxic ventilatory response, A value [the slope of the hyperbolic curve, V(E) = V(0) + A/(Pa(O)(2)-32)] and ratio of V(50) (the minute volume obtained from the hyperbolic equation when Pa(O)(2) = 50 mmHg) to V(0) were studied. These two parameters were examined at three states, sedative state with ketamine as the control, ketamine plus 0.1 MAC inhalation anesthetic, and ketamine plus 0.5 MAC inhalation anesthetic. In the sevoflurane group, the A values were 4789 +/- 1518, 2187 +/- 1214, 1730 +/- 880 (mean +/- SE. ml.min(-1).mmHg) at the control state, 0.1 MAC and 0.5 MAC, respectively. In the halothane group, the A values were 6411 +/- 2368, 2529 +/- 842 and 2372 +/- 545, respectively. The ratios of V(50) to V(0) were 1.32 +/- 0.09, 1.22 +/- 0.09, 1.25 +/- 0.08 in the sevoflurane group, 1.47 +/- 0.18, 1.32 +/- 0.11, 1.54 +/- 0.18 in the halothane group, respectively. The A value at 0.1 MAC of the halothane group was less than the control value significantly. This proved that even low concentration halothane depressed the hypoxic ventilatory responses. The depression of hypoxic ventilatory response could cause postanesthetic hypoventilation. On the other hand, we could not find significant depression on the hypoxic ventilatory response in the sevoflurane group, but we should notice that variances of the hypoxic ventilatory response were large.
Department of Anesthesiology and Critical Care Medicine, Hamamatsu University School of Medicine, Japan.
Tamura
C
C
Doi
M
M
Ikeda
K
K
eng
Journal Article
Japan
J Anesth
8905667
0913-8668
15284444
2004
08
12
2004
09
29
2010
09
21
0027-8424
101
32
2004
Aug
10
Proceedings of the National Academy of Sciences of the United States of America
Proc. Natl. Acad. Sci. U.S.A.
Tubular precipitation and redox gradients on a bubbling template.
11537-41
Tubular structures created by precipitation abound in nature, from chimneys at hydrothermal vents to soda straws in caves. Their formation is controlled by chemical gradients within which precipitation occurs, defining a surface that templates the growing structure. We report a self-organized periodic templating mechanism producing tubular structures electrochemically in iron-ammonium-sulfate solutions; iron oxides precipitate on the surface of bubbles that linger at the tube rim and then detach, leaving behind a ring of material. The acid-base and redox gradients spontaneously generated by diffusion of ammonia from the bubble into solution organize radial compositional layering within the tube wall, a mechanism studied on a larger scale by complex Liesegang patterns of iron oxides formed as ammonia diffuses through a gel containing FeSO(4). When magnetite forms within the wall, a tube may grow curved in an external magnetic field. Connections with free-boundary problems in speleothem formation are emphasized.
Department of Soil, Water, and Environmental Science, Program in Applied Mathematics, University of Arizona, Tucson, AZ 85721, USA.
Stone
David A
DA
Goldstein
Raymond E
RE
eng
Journal Article
2004
07
29
United States
Proc Natl Acad Sci U S A
7505876
0027-8424
J Geol Soc London. 1997 May;154(3):377-402
11541234
Nature. 2002 May 9;417(6885):139
12000951
Philos Trans R Soc Lond B Biol Sci. 2003 Jan 29;358(1429):59-83; discussion 83-5
12594918
J Am Chem Soc. 2003 Apr 9;125(14):4338-41
12670257
Science. 2003 Oct 24;302(5645):580-1
14576411
Science. 2004 Mar 12;303(5664):1656-8
15016997
PMC511016
5757641
1970
03
22
1970
03
22
2003
11
14
15
1968
Trudy Instituta fiziologii, Akademiia nauk Gruzinskoĭ SSR
Tr Inst Fiz Akad Nauk Gruz Ssr
[The effect of immediate stimulation of the hippocampus on reflex reactions in animals].
86-96
Tevzadze
V G
VG
geo
Journal Article
O vliianii neposredstvennogo razdrazheniia gippokampa na reflektornye reaktsii zhivotnykh.
USSR
Tr Inst Fiz Akad Nauk Gruz Ssr
7507618
IM
Animals
Dogs
Electric Stimulation
Hippocampus
physiology
Reflex
973217
1976
12
03
1976
12
03
2002
11
13
0095-3814
3
1
1976
Fall
Topics in health care financing
Top Health Care Financ
Hospital debt management and cost reimbursement.
69-81
Blume
F R
FR
eng
Journal Article
UNITED STATES
Top Health Care Financ
7509107
0095-3814
IM
Accounting
Economics, Hospital
Hospital Administration
United States
3549656
1987
05
15
1987
05
15
2006
11
15
0021-8820
40
1
1987
Jan
The Journal of antibiotics
J. Antibiot.
Semisynthetic beta-lactam antibiotics. III. Effect on antibacterial activity and comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid.
22-8
The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid (1a) to metabolism by catechol-O-methyl-transferase (COMT) was increased by introduction of the chlorine atom into the catechol moiety. Penicillins (1b-1d) having one or two chlorine atoms at the positions adjacent to the hydroxyl group were found to have greater stability to COMT. This resulted in greater efficiency in vivo in experimental Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged.
Ohi
N
N
Aoki
B
B
Kuroki
T
T
Matsumoto
M
M
Kojima
K
K
Nehashi
T
T
eng
Comparative Study
Journal Article
JAPAN
J Antibiot (Tokyo)
0151115
0021-8820
0
Anti-Bacterial Agents
0
Indicators and Reagents
0
Penicillins
0
beta-Lactams
88852-54-4
6-(2-(3-(5-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid
92773-65-4
6-(2-(3-(2-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid
92773-66-5
6-(2-(3-(2,5-dichloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid
EC 2.1.1.6
Catechol O-Methyltransferase
IM
Animals
Anti-Bacterial Agents
chemical synthesis
pharmacology
Bacteria
drug effects
Catechol O-Methyltransferase
antagonists & inhibitors
Escherichia coli Infections
drug therapy
Indicators and Reagents
Male
Mice
Mice, Inbred Strains
Microbial Sensitivity Tests
Penicillins
chemical synthesis
pharmacology
therapeutic use
Pseudomonas Infections
drug therapy
Structure-Activity Relationship
beta-Lactams
1875346
1991
09
25
1991
09
25
2008
11
21
0022-2623
34
8
1991
Aug
Journal of medicinal chemistry
J. Med. Chem.
3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives.
2489-95
Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and acutely in vivo for oral effectiveness as inhibitors of cholesterogenesis in the rat. Of the compounds selected for further biological evaluation, the 6 beta-methyl-5-oxa 10 and 5 alpha-hydroxy 16 derivatives of 3,4,4a,5-tetrahydro 2a, as well as, the 6 beta-epimer 14 of 16 proved orally active as hypocholesterolemic agents in cholestyramine-primed dogs. Subsequent acute oral metabolism studies in dogs demonstrated that compounds 14 and 16 evoke lower peak plasma drug activity and area-under-the-curve values than does compound 10 and led to the selection of 14 and 16 for toxicological evaluation.
Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
Duggan
M E
ME
Alberts
A W
AW
Bostedor
R
R
Chao
Y S
YS
Germershausen
J I
JI
Gilfillan
J L
JL
Halczenko
W
W
Hartman
G D
GD
Hunt
V
V
Imagire
J S
JS
eng
Journal Article
UNITED STATES
J Med Chem
9716531
0022-2623
0
6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
0
Acetates
0
Anticholesteremic Agents
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
57-88-5
Cholesterol
75330-75-5
Lovastatin
7782-44-7
Oxygen
79902-63-9
Simvastatin
IM
Acetates
metabolism
Animals
Anticholesteremic Agents
chemical synthesis
pharmacokinetics
pharmacology
Chemical Phenomena
Chemistry
Cholesterol
biosynthesis
Dogs
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Kinetics
Lovastatin
analogs & derivatives
chemical synthesis
chemistry
pharmacokinetics
pharmacology
Male
Molecular Conformation
Molecular Structure
Oxygen
Rats
Simvastatin
Structure-Activity Relationship
1669026
1993
11
15
1993
11
15
2008
11
21
0377-8231
Anniv No Pt 1
1991
Bulletin et mémoires de l'Académie royale de médecine de Belgique
Bull. Mem. Acad. R. Med. Belg.
[150th Anniversary Celebration of the Royal Academy of Medicine of Belgium. Part 1. Bruxelles, 26-28 September 1991].
1-191
fre
Congresses
Overall
Portraits
Célébration du CL Anniversaire de l'Académie Royal de Médecine de Belgique. Première partie. Bruxelles, 26-28 septembre 1991.
BELGIUM
Bull Mem Acad R Med Belg
7608462
0377-8231
IM
Academies and Institutes
Belgium
8219565
1993
12
08
1993
12
08
2004
11
17
1051-0443
4
5
1993 Sep-Oct
Journal of vascular and interventional radiology : JVIR
J Vasc Interv Radiol
Transcatheter manipulation of asymmetrically opened titanium Greenfield filters.
687-90
The problem of asymmetric opening of the modified hook titanium Greenfield inferior vena cava filter necessitating transcatheter manipulation was evaluated in a retrospective study.
Titanium Greenfield filters were placed in 166 patients over a 36-month period. The radiographic reports of all patients were reviewed to identify cases in which the filter failed to open symmetrically after deployment and catheter or wire manipulation of the filter was performed. The reports and angiograms from these patients were reviewed with respect to the circumstances surrounding filter placement and methods to achieve more symmetric opening.
Transcatheter manipulation of asymmetrically opened filters was performed in 15 of 166 cases (9%). In 12 of these patients, acceptable and uneventful opening of the filter was achieved with a guide wire, pigtail catheter, or occlusion balloon catheter. In one case manipulation only partly improved orientation of the limbs, while in another case successful manipulation was complicated by distal migration. In the final case, the asymmetric filter covered only part of the lumen of the vena cava despite manipulations and a second filter was placed for optimal caval interruption. No specific cause for incomplete expansion was identified in any case.
Marked asymmetry in opening of the modified hook titanium Greenfield filter that warrants manipulation occurs infrequently, but recognition and proper management may be important to ensure optimal caval interruption.
Department of Radiology, University of California at San Diego 92103.
Moore
B S
BS
Valji
K
K
Roberts
A C
AC
Bookstein
J J
JJ
eng
Journal Article
UNITED STATES
J Vasc Interv Radiol
9203369
1051-0443
7440-32-6
Titanium
IM
J Vasc Interv Radiol. 1993 Sep-Oct;4(5):617-20
8219555
J Vasc Interv Radiol. 1994 May-Jun;5(3):526-7
8054760
J Vasc Interv Radiol. 1994 May-Jun;5(3):528-32
8054761
Catheterization, Central Venous
Humans
Titanium
Vena Cava Filters
Vena Cava, Inferior
radiography
8119288
1994
04
01
1994
04
01
2007
07
23
0014-2956
220
1
1994
Feb
15
European journal of biochemistry / FEBS
Eur. J. Biochem.
Purification and characterisation of a water-soluble ferrochelatase from Bacillus subtilis.
201-8
Bacillus subtilis ferrochelatase is encoded by the hemH gene of the hemEHY gene cluster and catalyses the incorporation of Fe2+ into protoporphyrin IX. B. subtilis ferrochelatase produced in Escherichia coli was purified. It was found to be a monomeric, water-soluble enzyme of molecular mass 35 kDa which in addition to Fe2+ can incorporate Zn2+ and Cu2+ into protoporphyrin IX. Chemical modification experiments indicated that the single cysteine residue in the ferrochelatase is required for enzyme activity although it is not a conserved residue compared to other ferrochelatases. In growing B. subtilis, the ferrochelatase constitutes approximately 0.05% (by mass) of the total cell protein, which corresponds to some 600 ferrochelatase molecules/cell. The turnover number of isolated ferrochelatase, 18-29 min-1, was found to be consistent with the rate of haem synthesis in exponentially growing cells (0.2 mol haem formed/min/mol enzyme). It is concluded that the B. subtilis ferrochelatase has enzymic properties which are similar to those of other characterised ferrochelatases of known primary structure, i.e. ferrochelatases of the mitochondrial inner membrane of yeast and mammalian cells. However, in contrast to these enzymes the B. subtilis enzyme is a water-soluble protein and should be more amenable to structural analysis.
Department of Microbiology, Lund University, Sweden.
Hansson
M
M
Hederstedt
L
L
eng
Journal Article
Research Support, Non-U.S. Gov't
GERMANY
Eur J Biochem
0107600
0014-2956
7732-18-5
Water
EC 4.99.1.1
Ferrochelatase
IM
hemE
hemH
hemY
Amino Acid Sequence
Bacillus subtilis
enzymology
genetics
Catalysis
Cloning, Molecular
Escherichia coli
enzymology
genetics
Ferrochelatase
genetics
isolation & purification
metabolism
Gene Deletion
Genes, Bacterial
Kinetics
Molecular Sequence Data
Molecular Weight
Solubility
Water
11537092
1995
06
16
1995
06
16
2008
11
21
0033-183X
163
1991
Protoplasma
Protoplasma
Cytoplasmic calcium levels in protoplasts from the cap and elongation zone of maize roots.
181-8
Calcium has been implicated as a key component in the signal transduction process of root gravitropism. We measured cytoplasmic free calcium in protoplasts isolated from the elongation zone and cap of primary roots of light-grown, vertically oriented seedlings of Zea mays L. Protoplasts were loaded with the penta-potassium salts of fura-2 and indo-1 by incubation in acidic solutions of these calcium indicators. Loading increased with decreasing pH but the pH dependence was stronger for indo-1 than for fura-2. In the case of fura-2, loading was enhanced only at the lowest pH (4.5) tested. Dyes loaded in this manner were distributed predominantly in the cytoplasm as indicated by fluorescence patterns. As an alternative method of loading, protoplasts were incubated with the acetoxymethylesters of fura-2 and indo-1. Protoplasts loaded by this method exhibited fluorescence both in the cytoplasm and in association with various organelles. Cytoplasmic calcium levels measured using spectrofluorometry, were found to be 160 +/- 40 nM and 257 +/- 27 nM, respectively, in populations of protoplasts from the root cap and elongation zone. Cytoplasmic free calcium did not increase upon addition of calcium to the incubation medium, indicating that the passive permeability to calcium was low.
Department of Plant Biology, Ohio State University, Columbus.
Kiss
H G
HG
Evans
M L
ML
Johnson
J D
JD
eng
DMB 8608673
MB
BHP HRSA HHS
United States
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
AUSTRIA
Protoplasma
9806853
0033-183X
0
Fluorescent Dyes
0
Indoles
7440-70-2
Calcium
96314-96-4
indo-1
96314-98-6
Fura-2
S
Calcium
analysis
physiology
Cytoplasm
chemistry
Fluorescent Dyes
Fura-2
Gravitropism
physiology
Gravity Sensing
physiology
Indoles
Plant Root Cap
cytology
growth & development
physiology
Plant Roots
cytology
growth & development
physiology
Protoplasts
chemistry
physiology
Signal Transduction
Zea mays
cytology
growth & development
physiology
00015446
NASA Discipline Number 40-50
NASA Discipline Plant Biology
NASA Program Space Biology
Non-NASA Center
Evans
M L
ML
Ohio St U, Columbus, Dept Physiological Chemistry
Grant numbers: NAGW 297
11540070
1995
12
11
1995
12
11
2008
11
21
0735-2689
6
1
1987
Critical reviews in plant sciences
CRC Crit Rev Plant Sci
Calcium messenger system in plants.
47-103
Department of Horticulture, Washington State University, Pullman, USA.
Poovaiah
B W
BW
Reddy
A S
AS
eng
DCB-8502215
DC
NIDCD NIH HHS
United States
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review
UNITED STATES
CRC Crit Rev Plant Sci
9889759
0735-2689
0
Calcium-Binding Proteins
0
Calmodulin
0
Plant Growth Regulators
7440-70-2
Calcium
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinases
S
Amino Acid Sequence
Calcium
physiology
Calcium-Binding Proteins
physiology
Calcium-Calmodulin-Dependent Protein Kinases
metabolism
Calmodulin
metabolism
Gene Expression Regulation, Plant
Gravitropism
physiology
Molecular Sequence Data
Plant Growth Regulators
metabolism
Plant Physiological Phenomena
Plants
cytology
genetics
Second Messenger Systems
Signal Transduction
physiology
363
00012050
The purpose of this review is to delineate the ubiquitous and pivotal role of Ca2+ in diverse physiological processes. Emphasis will be given to the role of Ca2+ in stimulus-response coupling. In addition to reviewing the present status of research, our intention is to critically evaluate the existing data and describe the newly developing areas of Ca2+ research in plants.
NASA Edited
NASA Discipline Number 40-30
NASA Discipline Plant Biology
NASA Program Space Biology
Non-NASA Center
Poovaiah
B W
BW
WA St U, Pullman, Dept Horticulture
Grant numbers: NAG-10-0032
8655018
1996
07
30
1996
07
30
2008
11
21
0017-0011
67
1
1996
Jan
Ginekologia polska
Ginekol. Pol.
[Effect of fetal and neonatal growth on the occurrence of some diseases in adults].
34-6
The findings of many authors show that reduced fetal growth is followed by increased mortality from cardiovascular disease in adult life. They are further evidence that cardiovascular disease originates, among other risk factors, through programming of the bodies structure and metabolism during fetal and early post-natal life. Wrong maternal nutrition may have an important influence on programming.
Katedry i Zakładu Chemii i Analizy Leków, AM w Katowicach.
Jendryczko
A
A
Poreba
R
R
pol
English Abstract
Journal Article
Retracted Publication
Review
Wpływ przebiegu rozwoju płodu i noworodka na ujawnienie sie niektórych chorób okresu dorosłego.
POLAND
Ginekol Pol
0374641
0017-0011
IM
Ginekol Pol. 1998 Jul;69(7):561
9867475
Ginekol Pol. 1998 Jul;69(7):559-60
9867474
Adult
Cardiovascular Diseases
etiology
mortality
Child Development
physiology
Embryonic and Fetal Development
physiology
Fetal Growth Retardation
complications
physiopathology
Humans
Infant, Newborn
Nutritional Physiological Phenomena
Risk Factors
Survival Rate
11
9110943
1996
10
23
1996
10
23
2007
11
15
1059-2725
Doc No 200-201
1996
Jul
30
The Online journal of current clinical trials
Online J Curr Clin Trials
Conservative management of mechanical neck disorders. A systematic overview and meta-analysis.
[34457 words; 185 paragraphs]
This overview reports the efficacy of conservative treatments (drug therapy, manual therapy, patient education, physical medicine modalities) in reducing pain in adults with mechanical neck disorders.
Computerized bibliographic database searches from 1985 to December 1993, information requests from authors, and bibliography screenings were used to identify published and unpublished research. Applying strict criteria, two investigators independently reviewed the blinded articles. Each selected trial was evaluated independently for methodologic quality.
Twenty-four randomized controlled trials (RCTs) and eight before-after studies met our selection criteria. Twenty RCTs rated moderately strong or better in terms of methodologic quality. Five trials using manual therapy in combination with other treatments were clinically similar, were statistically not heterogeneous (p = 0.98), and were combined to yield an effect size of -0.6 (95% CI: -0.9, -0.4), equivalent to a 16 point improvement on a 100 point pain scale. Four RCTs using physical medicine modalities were combined using the inverse chi-square method: two using electromagnetic therapy produced a significant reduction in pain (p < 0.01); and two using laser therapy did not differ significantly from a placebo (p = 0.63). Little or no scientific evidence exists for other therapies, including such commonly used treatments as medication, rest and exercise.
Within the limits of methodologic quality, the best available evidence supports the use of manual therapies in combination with other treatments for short-term relief of neck pain. There is some support for the use of electromagnetic therapy and against the use of laser therapy. In general, other interventions have not been studied in enough detail adequately to assess efficacy or effectiveness. This overview provides the foundation for an evidence-based approach to practice. More robust design and methodology should be used in future research, in particular, the use of valid and reliable outcomes measures.
Chedoke-McMaster Hospitals & Schools of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Gross
A R
AR
Aker
P D
PD
Goldsmith
C H
CH
Peloso
P
P
eng
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
UNITED STATES
Online J Curr Clin Trials
9300367A
1059-2725
IM
Acupuncture Therapy
Adult
Chiropractic
Databases, Bibliographic
Humans
Manipulation, Orthopedic
Neck Injuries
Pain
drug therapy
rehabilitation
therapy
Patient Education as Topic
Physical Therapy Modalities
Randomized Controlled Trials as Topic
Reproducibility of Results
Wounds and Injuries
drug therapy
rehabilitation
therapy
11612527
1991
03
18
1991
03
18
2007
11
15
0032-4728
44
3
1990
Nov
Population studies
Popul Stud (Camb)
On the origins of the United States Government's international population policy.
385-99
Donaldson
P J
PJ
eng
Historical Article
Journal Article
ENGLAND
Popul Stud (Camb)
0376427
0032-4728
E
Q
QO
Demography
History, Modern 1601-
Politics
Statistics as Topic
history
United States
World Health
36117
Agency for International Development
Genetics and Reproduction
50 fn.
KIE Bib: population control
11620107
1988
11
16
1988
11
16
2007
11
15
0511-0726
24
1984
A.A.G. bijdragen / Afdeling Agrarische Geschiedenis, Landbouwhogeschool
A A G Bijdr
Demographic transition in the Netherlands: a statisticsl analysis of regional differences in the level and development of the birth rate and of fertility, 1850-1890.
1-57
Boonstra
O W
OW
van der Woude
A M
AM
eng
Historical Article
Journal Article
NETHERLANDS
A A G Bijdr
100966038
0511-0726
Q
QO
Demography
History, Modern 1601-
Netherlands
Statistics as Topic
history
11675721
1976
07
01
1976
07
01
2007
11
15
0024-2160
2
2
1974
Jun
The Library
Library (Lond)
Thomas Dover's "Ancient physician's legacy".
228
Payne
L M
LM
eng
Biography
Historical Article
Journal Article
ENGLAND
Library (Lond)
100969413
0024-2160
Q
QO
Bibliography as Topic
Great Britain
History, Modern 1601-
Printing
history
Dover
T
T
8863847
1996
11
25
1996
11
25
2009
11
19
0026-895X
50
4
1996
Oct
Molecular pharmacology
Mol. Pharmacol.
Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.
1000-9
The mitogenic effect of extracellular ATP was examined in cultured rat aortic smooth muscle cells (VSMCs). ATP, 2-methylthio-ATP, and ADP stimulated [3H]thymidine and [3H]leucine incorporation and cell growth. AMP, adenosine, UTP, and P2x agonists showed little of these effects. Reactive blue 2, a P2Y purinoceptor antagonist, was effective in suppressing the mitogenic effect of ATP and 2-methylthio-ATP, indicating that extracellular ATP-induced VSMC proliferation is mediated by P2Y purinoceptors. The P2Y purinoceptor activation was coupled to a pertussis toxin (PTX)-insensitive G protein (Gq) and triggered phosphoinositide hydrolysis with subsequent activation of protein kinase C (PKC), Raf-1, and mitogen-activated protein kinase (MAPK) in VSMCs. In response to ATP, both 42-and 44-kDa MAPKs were activated, and tyrosine was phosphorylated. Western blot analysis using PKC isozyme-specific antibodies indicated that VSMCs express PKC-alpha, PKC-delta, and PKC-zeta. A complete down-regulation of PKC-alpha and PKC-delta was seen after 24-hr treatment with 12-O-tetradecanoylphorbol-13-acetate. When cells were pretreated with 12-O-tetradecanoyl-phorbol-13-acetate for 24 hr and subsequently challenged with ATP, Raf-1 activation and 42-kDa as well as 44-kDa MAPK tyrosine phosphorylation failed to be induced. These results demonstrate that ATP-induced Raf-1 and MAPK activations involve the activation of PKC-alpha and PKC-delta. P2Y purinoceptor stimulation with ATP also caused accumulation of c-fos and c-myc mRNAs. Both Reactive blue 2 and staurosporine significantly blocked this increase by ATP. In conclusion, the mitogenic effect of ATP seemed to be triggered by activation of the Gq protein-coupled P2Y purinoceptor that led to the formation of inositol trisphosphate and activation of PKC. PKC and, in turn, Raf-1 and MAPK were then activated, leading eventually to DNA synthesis and cell proliferation.
Department of Pharmacology, Chang Gung College of Medicine and Technology, Kwei-San, Tao-Yuan, Taiwan. smyu@cguaplo.cgu.edu
Yu
S M
SM
Chen
S F
SF
Lau
Y T
YT
Yang
C M
CM
Chen
J C
JC
eng
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Retracted Publication
UNITED STATES
Mol Pharmacol
0035623
0026-895X
0
Proto-Oncogene Proteins
0
RNA, Messenger
0
Receptors, Purinergic P2
0
Transcription Factors
10028-17-8
Tritium
50-89-5
Thymidine
56-65-5
Adenosine Triphosphate
61-90-5
Leucine
9007-49-2
DNA
EC 2.7.11.1
Protein-Serine-Threonine Kinases
EC 2.7.11.1
Proto-Oncogene Proteins c-raf
EC 2.7.11.13
Protein Kinase C
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinases
EC 3.6.1.-
GTP-Binding Proteins
IM
Mol Pharmacol 1997 Mar;51(3):533
Wu D, Yang CM, Lau YT, Chen JC. Mol Pharmacol. 1998 Feb;53(2):346
9499167
Adenosine Triphosphate
pharmacology
Animals
Aorta
cytology
drug effects
metabolism
Calcium-Calmodulin-Dependent Protein Kinases
metabolism
Cell Count
Cell Division
drug effects
Cells, Cultured
DNA
biosynthesis
Enzyme Activation
Extracellular Space
metabolism
GTP-Binding Proteins
metabolism
physiology
Leucine
metabolism
Muscle, Smooth, Vascular
cytology
drug effects
metabolism
Protein Kinase C
metabolism
Protein-Serine-Threonine Kinases
metabolism
Proto-Oncogene Proteins
metabolism
Proto-Oncogene Proteins c-raf
RNA, Messenger
metabolism
Rats
Rats, Sprague-Dawley
Receptors, Purinergic P2
physiology
Signal Transduction
physiology
Stimulation, Chemical
Thymidine
metabolism
Transcription Factors
biosynthesis
Tritium
8941094
1997
01
02
1997
01
02
2004
11
17
0009-7322
94
11
1996
Dec
1
Circulation
Circulation
Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201Tl tomography versus dobutamine echocardiography.
2712-9
To date, late redistribution after resting 201Tl injection has not been evaluated. In addition, the concordance between resting 201Tl imaging and dobutamine echocardiography in identifying viable myocardium has not been assessed.
Forty patients with coronary artery disease underwent rest-4-hour-24-hour 201Tl tomography and dobutamine echocardiography (5 to 10 micrograms.kg-1.min-1). Late redistribution occurred in 46 (21%) of 219 persistent defects at 4 hours. Systolic function and contractile reserve were similar among persistent defects at 4 hours with and without late redistribution. Contractile reserve was more frequent in segments with normal 201Tl uptake (59%), completely reversible defects (53%), or mild to moderate defects at 4 hours (56%) compared with severe defects (14%; P < .02 versus all). Of 105 hypokinetic segments, 99 (94%) were viable by 201Tl, and 88 (84%) showed contractile reserve. In contrast, of 155 akinetic segments, 119 (77%) were viable by 201Tl, but only 34 (22%) had contractile reserve. Concordance between 201Tl and dobutamine was 82% in hypokinetic segments but 43% in akinetic segments. In 109 revascularized segments, positive accuracy for functional recovery was 72% for 201Tl and 92% for dobutamine, whereas negative accuracy was 100% and 65%, respectively. Sensitivity was 100% for 201Tl and 79% for dobutamine.
Late redistribution occurs in one fifth of persistent defects at 4 hours, and it does not correlate to systolic function or contractile reserve. Dobutamine and 201Tl yield concordant information in the majority of hypokinetic segments, whereas concordance is low in akinetic segments. Dobutamine demonstrates higher positive accuracy and sensitivity in predicting recovery of dysfunctional myocardium, whereas 201Tl shows higher negative predictive accuracy but reduced positive accuracy.
Division of Cardiology, Federico II University Medical School, Naples, Italy.
Perrone-Filardi
P
P
Pace
L
L
Prastaro
M
M
Squame
F
F
Betocchi
S
S
Soricelli
A
A
Piscione
F
F
Indolfi
C
C
Crisci
T
T
Salvatore
M
M
Chiariello
M
M
eng
Journal Article
UNITED STATES
Circulation
0147763
0009-7322
0
Thallium Radioisotopes
34368-04-2
Dobutamine
AIM
IM
Circulation. 1997 Oct 21;96(8):2740-2
9355926
Circulation. 1996 Dec 1;94(11):2681-4
8941086
Circulation. 1996 Dec 1;94(11):2674-80
8941085
Circulation. 1996 Dec 1;94(11):2685-8
8941087
Aged
Cell Survival
Chronic Disease
Circadian Rhythm
Coronary Disease
physiopathology
radionuclide imaging
ultrasonography
Dobutamine
diagnostic use
Echocardiography
Follow-Up Studies
Heart
radionuclide imaging
Humans
Male
Middle Aged
Myocardial Contraction
Myocardial Revascularization
Rest
Systole
Thallium Radioisotopes
diagnostic use
pharmacokinetics
Time Factors
Ventricular Dysfunction, Left
radionuclide imaging
therapy
ultrasonography
10168751
1997
08
28
1997
08
28
2006
11
15
0168-8510
40
3
1997
Jun
Health policy (Amsterdam, Netherlands)
Health Policy
Health technology assessment: decentralized and fragmented in the US compared to other countries.
177-98
This paper presents the results of the first comprehensive international survey to catalogue health technology assessment (HTA) activities. By 1995, there were formal HTA programs in 24 countries established mostly in the late 1980s and early 1990s. European countries generally have one or two federal or provincial HTA programs each, Canada has an extensive network of federal and regional organizations coordinated by a central body and the US has 53 HTA organizations, the vast majority of which are in the private sector. While the commitment of the US government to HTA has been erratic, the private sector has been witness to an expansion of HTA activities by insurance companies, hospitals, medical/device manufacturers, consulting firms and health professional societies. In contrast to other developed countries, the current state of technology assessment in the US is decentralized, fragmented and duplicative. We conclude by discussing the importance of a US HTA agency at the national level.
Medical Technology and Practice Patterns Institute, WHO Collaborating Center on Health Technology Assessment, Washington, DC 20007, USA.
Perry
S
S
Thamer
M
M
eng
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
IRELAND
Health Policy
8409431
0168-8510
H
Health Policy 1997 Dec;42(3):269-90
Canada
Diffusion of Innovation
Europe
Health Care Surveys
Health Policy
Information Services
Private Sector
Technology Assessment, Biomedical
legislation & jurisprudence
methods
organization & administration
statistics & numerical data
United States
United States Office of Technology Assessment
9394824
1998
01
02
1998
01
02
2006
11
15
0014-2980
27
11
1997
Nov
European journal of immunology
Eur. J. Immunol.
Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells.
2959-64
In this work we have microdissected lamina propria plasma cells and used polymerase chain reaction and sequencing to investigate immunoglobulin (Ig) gene rearrangements and mutations in human intestine. In addition, specific primers were designed for individual Ig gene rearrangements to analyze the distribution of related B cell and plasma cell clones at different sites along the bowel. Confirming our earlier work, intestinal IgVH genes were highly mutated in plasma cells from older individuals (> 30 years). IgVH genes were significantly less mutated in samples taken from patients aged 11-30 years, and there were fewer mutations again in samples from young children (< 11 years). In age-matched specimens the number of mutations was equivalent in the duodenum and colon. Using complementarity-determining region 3 primers to amplify specific Ig gene rearrangements, evidence was also found for the existence of related lamina propria plasma cells along the small bowel and colon, although these were quite scarce. In addition, analysis of the numbers of related clones in a random sampling from discrete areas of lamina propria indicates that the local population is diverse. These results suggest that the highly mutated IgVH genes in adult intestinal plasma cells are a consequence of chronic antigen exposure with age. Duodenal plasma cells are as highly mutated as colonic plasma cells, despite the fact that the upper bowel has no indigenous microbial flora (the stimulus for intestinal plasma cells). They also show that the plasma cell population is diverse and can be widely disseminated along the bowel.
Department of Histopathology, UMDS, London, Great Britain.
Dunn-Walters
D K
DK
Boursier
L
L
Spencer
J
J
eng
GENBANK
Z93128
Z93129
Z93130
Z93131
Z93132
Z93133
Z93134
Z93135
Z93136
Z93137
Z93138
Z93139
Z93140
Z93141
Z93142
Z93143
Z93144
Z93145
Z93146
Z93147
Z93148
Z93149
Z93150
Z93151
Z93152
Z93153
Z93154
Z93155
Z93156
Z93157
Journal Article
Research Support, Non-U.S. Gov't
GERMANY
Eur J Immunol
1273201
0014-2980
0
Immunoglobulin Heavy Chains
0
Immunoglobulin Variable Region
IM
Adolescent
Adult
Aged
Aged, 80 and over
Aging
genetics
immunology
Base Sequence
Child
Colon
immunology
metabolism
Duodenum
immunology
metabolism
Gene Rearrangement
immunology
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
genetics
Immunoglobulin Variable Region
genetics
Infant
Intestinal Mucosa
cytology
immunology
Middle Aged
Molecular Sequence Data
Mutation
Organ Specificity
genetics
immunology
Plasma Cells
immunology
metabolism
9482442
1998
03
18
1998
03
18
2004
11
17
0140-6736
351
9101
1998
Feb
14
Lancet
Lancet
A woman with nodules in her lungs.
494
Department of Medicine, Turku University Central Hospital, Finland.
Järveläinen
H
H
Vainionpää
H
H
Kuopio
T
T
Lehtonen
A
A
eng
Case Reports
Journal Article
ENGLAND
Lancet
2985213R
0140-6736
0
Powders
7631-86-9
Silicon Dioxide
AIM
IM
Lancet 1998 Mar 7;351(9104):760
Lancet 1998 Jun 27;351(9120):1968
Aged
Female
Humans
Naturopathy
Powders
Silicon Dioxide
administration & dosage
Silicosis
etiology
radiography
9505772
1998
03
24
1998
03
24
2004
11
17
0007-0912
80
1
1998
Jan
British journal of anaesthesia
Br J Anaesth
Myocardial ischaemia after coronary artery bypass grafting: early vs late extubation.
20-5
The technique of early extubation after coronary artery bypass grafting is increasing in popularity, but its safety and effect on myocardial ischaemia remain to be established. In a randomized, prospective study, patients undergoing routine elective coronary artery bypass grafting were managed with either early or late tracheal extubation. The incidence and severity of electrocardiographic myocardial ischaemia were compared. Data were analysed from 85 patients (43 early extubation; 42 late extubation). Median time to extubation was 110 min in the early extubation patients and 757 min in the late extubation patients. After correction for randomization bias, there were no significant differences between groups in ischaemic burden, maximal ST-segment deviation, incidence of ischaemia and area under the ST deviation-time curve (integral of ST deviation and time). Similarly, there were no differences between groups in postoperative creatine kinase MB-isoenzyme concentrations and duration of stay in the ICU or hospital. Therefore, this study provides evidence for the safety of early extubation after routine coronary artery bypass grafting.
Cardiothoracic Centre Liverpool-NHS Trust.
Berry
P D
PD
Thomas
S D
SD
Mahon
S P
SP
Jackson
M
M
Fox
M A
MA
Fabri
B
B
Weir
W I
WI
Russell
G N
GN
eng
Clinical Trial
Journal Article
Randomized Controlled Trial
ENGLAND
Br J Anaesth
0372541
0007-0912
IM
Br J Anaesth 1998 Apr;80(4):572
Br J Anaesth 1998 Jul;81(1):111
Adult
Aged
Coronary Artery Bypass
adverse effects
Electrocardiography
Female
Humans
Intubation, Intratracheal
methods
Male
Middle Aged
Myocardial Ischemia
etiology
Postoperative Care
methods
Postoperative Period
Prospective Studies
Treatment Outcome
9575322
1998
05
12
1998
05
12
2007
11
15
0002-838X
57
8
1998
Apr
15
American family physician
Am Fam Physician
Lumbar spine stenosis: a common cause of back and leg pain.
1825-34, 1839-40
Lumbar spine stenosis most commonly affects the middle-aged and elderly population. Entrapment of the cauda equina roots by hypertrophy of the osseous and soft tissue structures surrounding the lumbar spinal canal is often associated with incapacitating pain in the back and lower extremities, difficulty ambulating, leg paresthesias and weakness and, in severe cases, bowel or bladder disturbances. The characteristic syndrome associated with lumbar stenosis is termed neurogenic intermittent claudication. This condition must be differentiated from true claudication, which is caused by atherosclerosis of the pelvofemoral vessels. Although many conditions may be associated with lumbar canal stenosis, most cases are idiopathic. Imaging of the lumbar spine performed with computed tomography or magnetic resonance imaging often demonstrates narrowing of the lumbar canal with compression of the cauda equina nerve roots by thickened posterior vertebral elements, facet joints, marginal osteophytes or soft tissue structures such as the ligamentum flavum or herniated discs. Treatment for symptomatic lumbar stenosis is usually surgical decompression. Medical treatment alternatives, such as bed rest, pain management and physical therapy, should be reserved for use in debilitated patients or patients whose surgical risk is prohibitive as a result of concomitant medical conditions.
University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio, USA.
Alvarez
J A
JA
Hardy
R H
RH
Jr
eng
Journal Article
Review
UNITED STATES
Am Fam Physician
1272646
0002-838X
AIM
IM
Am Fam Physician. 1999 Jan 15;59(2):280, 283-4
9930124
Diagnosis, Differential
Humans
Low Back Pain
etiology
Lumbosacral Region
Pain
etiology
Patient Education as Topic
Spinal Stenosis
complications
diagnosis
physiopathology
therapy
Teaching Materials
13
9626910
1998
08
12
1998
08
12
2006
11
15
0047-1828
62
5
1998
May
Japanese circulation journal
Jpn. Circ. J.
Hepatitis C virus infection and heart diseases: a multicenter study in Japan.
389-91
As a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, a questionnaire was sent out to 19 medical institutions in Japan in order to examine the possible association between hepatitis C virus (HCV) infection and cardiomyopathies. Hepatitis C virus antibody was found in 74 of 697 patients (10.6%) with hypertrophic cardiomyopathy (mean age, 57.7 years) and in 42 of 663 patients (6.3%) with dilated cardiomyopathy (mean age, 56.5 years); these prevalences were significantly higher than that found in volunteer blood donors in Japan (2.4%, 50-59 years of age, each p<0.0001). The prevalence was significantly higher in patients suffering from hypertrophic cardiomyopathy as opposed to those with dilated cardiomyopathy (p<0.01). The presence of HCV antibody was detected in 650 of 11,967 patients (5.4%) patients seeking care in 5 academic hospitals. Various cardiac abnormalities were found among these patients, arrhythmias being the most frequent. These observations suggest that HCV infection is an important cause of a variety of otherwise unexplained heart diseases.
Kyoto University, Japan.
Matsumori
A
A
Ohashi
N
N
Hasegawa
K
K
Sasayama
S
S
Eto
T
T
Imaizumi
T
T
Izumi
T
T
Kawamura
K
K
Kawana
M
M
Kimura
A
A
Kitabatake
A
A
Matsuzaki
M
M
Nagai
R
R
Tanaka
H
H
Hiroe
M
M
Hori
M
M
Inoko
H
H
Seko
Y
Y
Sekiguchi
M
M
Shimotohno
K
K
Sugishita
Y
Y
Takeda
N
N
Takihara
K
K
Tanaka
M
M
Yokoyama
M
M
eng
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
AUSTRALIA
Jpn Circ J
7806868
0047-1828
0
Hepatitis C Antibodies
IM
Cardiomyopathies
epidemiology
etiology
virology
Heart
virology
Heart Diseases
epidemiology
etiology
virology
Hepacivirus
immunology
Hepatitis C
complications
Hepatitis C Antibodies
blood
Humans
Japan
epidemiology
Middle Aged
Myocardium
immunology
pathology
Prevalence
Questionnaires
9627170
1998
08
25
1998
08
25
2006
11
15
1435-2443
383
1
1998
Mar
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie
Langenbecks Arch Surg
Outcome of patients with sepsis and septic shock after ICU treatment.
44-8
OBJECTIVE: Today, sepsis syndrome is the leading cause of death in adult, non-coronary intensive care units (ICUs) and is of great clinical importance. The purpose of this review was to evaluate recent prospective studies concerning the short- and long-term prognosis of patients suffering from systemic inflammatory-response syndrome (SIRS), sepsis, severe sepsis and septic shock. It has been shown in multicentre prospective surveys that 1% and 0.3% of all patients admitted to hospitals suffer, respectively, from bacteraemia alone and bacteraemia with severe sepsis. This rate increases, of course, when only admissions to the ICUs are considered: the above-mentioned rates increase then by a factor of 8 and 30, respectively. Thus, approximately 10% of patients in the ICU suffer from sepsis, 6% from severe sepsis and 2-3% from septic shock. SIRS occurs more frequently and its occurrence ranges from 40% to 70% of all patients admitted to ICUs. Thereby, 40-70% suffering from SIRS progress to a more severe septic-disease state. The overall prognosis is still poor, despite the recent advances in ICU treatment. The mortality rate of SIRS ranges from 6% to 7% and in septic shock amounts to over 50%. In particular, abdominal sepsis exhibits the highest mortality rate with 72%. The long-term prognosis is equally poor; only approximately 30% survived the first year after hospital admission. CONCLUSION: The prognosis of sepsis and septic shock remains poor, despite the advances in ICU treatment. Although prognostic factors have been identified for some patients, groups have not yet been able to identify the immediate or long-term prognosis for the majority of these septic patients.
Department of General Surgery, University of Ulm, Germany.
Schoenberg
M H
MH
Weiss
M
M
Radermacher
P
P
eng
Journal Article
Review
GERMANY
Langenbecks Arch Surg
9808285
1435-2443
IM
Adult
Bacteremia
mortality
therapy
Cause of Death
Female
Humans
Intensive Care
Male
Prognosis
Prospective Studies
Shock, Septic
mortality
therapy
Surgical Wound Infection
mortality
therapy
Survival Rate
Systemic Inflammatory Response Syndrome
mortality
therapy
21
9634358
1998
06
18
1998
06
18
2004
03
31
0022-1899
177
6
1998
Jun
The Journal of infectious diseases
J. Infect. Dis.
Retraction: A rabbit model for human cytomeglovirus--induced chorioretinal disease (J Infect Dis 1993;168:336-44).
1778
Dunkel
E C
EC
Scheer
D I
DI
Zhu
Q
Q
Whitley
R J
RJ
Schaffer
P A
PA
Pavan-Langston
D
D
Whitely
R J
RJ
eng
Retraction of Publication
UNITED STATES
J Infect Dis
0413675
0022-1899
AIM
IM
J Infect Dis 1998 Aug;178(2):601
Whitely RJ [corrected to Whitley RJ]
Dunkel EC, de Freitas D, Scheer DI, Siegel ML, Zhu Q, Whitley RJ, Schaffer PA, Pavan-Langston D. J Infect Dis. 1993 Aug;168(2):336-44
8393056
9861576
1999
03
29
1999
03
29
2010
02
25
0268-1315
13
6
1998
Nov
International clinical psychopharmacology
Int Clin Psychopharmacol
Cardiac side-effects of two selective serotonin reuptake inhibitors in middle-aged and elderly depressed patients.
263-7
Selective serotonin reuptake inhibitors (SSRIs) are the 'new' drugs of first choice for the treatment of depression in the older patient. Systematic studies on the effects of SSRIs on cardiac function are scarce, despite the high prevalence of cardiac disorders in the older depressed patient. This is a study which systematically assessed cardiac function by echocardiography in middle-aged and elderly depressed patients treated with SSRI. In a double-blind randomized trial, 20 patients were assigned to receive fluvoxamine 100 mg/day [DOSAGE ERROR CORRECTED] or fluoxetine 20 mg/day [DOSAGE ERROR CORRECTED] for 6 weeks. Cardiac function was assessed by left ventricle ejection fraction, aortic flow integral and early or passive/late or active mitral inflow, and electrocardiography. Neither SSRI significantly affected cardiac function. Compared with patients without a history of myocardial infarction and/or hypertension, patients with such a history showed a significant improvement in left ventricular ejection fraction. Despite our small study sample, these data indicate that both fluoxetine and fluvoxamine do not affect cardiac function adversely.
Department of Psychiatry, Maastricht University Hospital, The Netherlands.
Strik
J J
JJ
Honig
A
A
Lousberg
R
R
Cheriex
E C
EC
Van Praag
H M
HM
eng
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
ENGLAND
Int Clin Psychopharmacol
8609061
0268-1315
0
Serotonin Uptake Inhibitors
54739-18-3
Fluvoxamine
54910-89-3
Fluoxetine
IM
Int Clin Psychopharmacol 1999 Mar;14(2):138
Dosage error in published abstract; MEDLINE/PubMed abstract corrected
Aged
Aged, 80 and over
Cardiovascular Diseases
chemically induced
physiopathology
Depressive Disorder
complications
drug therapy
Double-Blind Method
Echocardiography
Electrocardiography
drug effects
Female
Fluoxetine
adverse effects
therapeutic use
Fluvoxamine
adverse effects
therapeutic use
Humans
Male
Middle Aged
Serotonin Uptake Inhibitors
adverse effects
therapeutic use
9885794
1999
03
29
1999
03
29
2010
09
15
0893-133X
20
2
1999
Feb
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Neuropsychopharmacology
Antipsychotic potential of CCK-based treatments: an assessment using the prepulse inhibition model of psychosis.
141-9
Systemic injections of cholecystokinin (CCK), a "gut-brain" peptide, have been shown to modulate brain dopamine function and produce neuroleptic-like effects on such dopamine-regulated behaviors as locomotor activity. However, clinical trials of CCK agonists in schizophrenia patients showed mixed results. To re-examine the antipsychotic potential of CCK-based treatments, we examined systemic injections of CCK analogs in an animal model with strong face and construct validity for sensorimotor-gating deficits seen in schizophrenia patients and with strong predictive validity for antipsychotic drug activity. Prepulse inhibition (PPI) occurs when a weak acoustic lead stimulus ("prepulse") inhibits the startle response to a sudden loud sound ("pulse"). PPI is significantly reduced in schizophrenia patients and rats treated with dopamine agonists. Antipsychotics reverse decreased PPI in rats to a degree highly correlated with their clinical efficacy. Subcutaneous (s.c.) injections of caerulein (10 micrograms/kg) a mixed CCKA/B agonist, partially reversed amphetamine-induced reduction of PPI; whereas, s.c. haloperidol (0.5 mg/kg) totally reversed amphetamine-induced disruption of PPI. Caerulein's effect on PPI was blocked by pretreatment with a CCKA antagonist (devazepide) but not a CCKB antagonist (L-365,260). CCK-4, a preferential CCKB agonist, had no significant effect on PPI. These results suggest that caerulein produces a weak neuroleptic-like effect on PPI that is mediated by stimulation of CCKA receptors. Possible circuities in this effect are discussed. In a separate experiment, s.c. caerulein produced to a more potent neuroleptic-like profile on amphetamine-induced hyperlocomotion, suggesting that selection of preclinical paradigms may be important in evaluating the antipsychotic potential of CCK-based treatments.
Department of Psychiatry, University of California, San Diego, La Jolla 92093-8620, USA.
Feifel
D
D
Reza
T
T
Robeck
S
S
eng
Journal Article
Research Support, Non-U.S. Gov't
UNITED STATES
Neuropsychopharmacology
8904907
0
Antipsychotic Agents
0
Gastrointestinal Agents
0
Receptors, Cholecystokinin
17650-98-5
Caerulein
1947-37-1
Tetragastrin
52-86-8
Haloperidol
9011-97-6
Cholecystokinin
IM
Animals
Antipsychotic Agents
administration & dosage
therapeutic use
Behavior, Animal
drug effects
Caerulein
therapeutic use
Cholecystokinin
physiology
Gastrointestinal Agents
therapeutic use
Haloperidol
administration & dosage
therapeutic use
Injections, Subcutaneous
Male
Motor Activity
drug effects
Psychotic Disorders
drug therapy
psychology
Rats
Rats, Sprague-Dawley
Receptors, Cholecystokinin
antagonists & inhibitors
drug effects
Startle Reaction
drug effects
Tetragastrin
antagonists & inhibitors
pharmacology
9929727
1999
04
28
1999
04
28
2004
11
17
0300-2896
34
11
1998
Dec
Archivos de bronconeumología
Arch. Bronconeumol.
[Tobacco control in children, adolescents and young people: knowledge, prevention and action].
564
de Granda Orive
J I
JI
Peña Miguel
T
T
Morato Arnáiz
A
A
spa
Comment
Letter
La lucha contra el tabaco en los niños, adolescentes y jóvenes: conocimiento, prevención y actuación.
SPAIN
Arch Bronconeumol
0354720
0300-2896
IM
Arch Bronconeumol. 1998 Apr;34(4):199-203
9611655
Adolescent
Adult
Child
Female
Health Knowledge, Attitudes, Practice
Humans
Male
Smoking
prevention & control
10078868
1999
06
09
1999
06
09
2005
11
17
0041-0101
37
2
1999
Feb
Toxicon : official journal of the International Society on Toxinology
Toxicon
Bibliography of toxinology.
399-404
eng
Bibliography
ENGLAND
Toxicon
1307333
0041-0101
0
Toxins, Biological
IM
Toxins, Biological
10083987
1999
05
11
1999
05
11
2004
11
17
0832-610X
46
2
1999
Feb
Canadian journal of anaesthesia = Journal canadien d'anesthésie
Can J Anaesth
Complete airway obstruction.
99-104
Crosby
E T
ET
eng
fre
Comment
Editorial
CANADA
Can J Anaesth
8701709
0832-610X
0
Anesthetics, Local
IM
Can J Anaesth. 1999 Feb;46(2):176-8
10083999
Airway Obstruction
etiology
surgery
Anesthesiology
education
Anesthetics, Local
administration & dosage
Cervical Vertebrae
injuries
Conscious Sedation
adverse effects
methods
Humans
Intubation, Intratracheal
adverse effects
instrumentation
methods
Laryngoscopes
Laryngoscopy
adverse effects
methods
Tracheostomy
10097079
1999
05
12
1999
05
12
2009
11
18
0027-8424
96
7
1999
Mar
30
Proceedings of the National Academy of Sciences of the United States of America
Proc. Natl. Acad. Sci. U.S.A.
Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species.
3578-83
The genome sequence of the extremely thermophilic archaeon Methanococcus jannaschii provides a wealth of data on proteins from a thermophile. In this paper, sequences of 115 proteins from M. jannaschii are compared with their homologs from mesophilic Methanococcus species. Although the growth temperatures of the mesophiles are about 50 degrees C below that of M. jannaschii, their genomic G+C contents are nearly identical. The properties most correlated with the proteins of the thermophile include higher residue volume, higher residue hydrophobicity, more charged amino acids (especially Glu, Arg, and Lys), and fewer uncharged polar residues (Ser, Thr, Asn, and Gln). These are recurring themes, with all trends applying to 83-92% of the proteins for which complete sequences were available. Nearly all of the amino acid replacements most significantly correlated with the temperature change are the same relatively conservative changes observed in all proteins, but in the case of the mesophile/thermophile comparison there is a directional bias. We identify 26 specific pairs of amino acids with a statistically significant (P < 0.01) preferred direction of replacement.
Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA.
Haney
P J
PJ
Badger
J H
JH
Buldak
G L
GL
Reich
C I
CI
Woese
C R
CR
Olsen
G J
GJ
eng
GENBANK
AF078607
AF078608
AF078609
AF078610
AF078611
AF078612
AF078613
AF078614
AF078615
AF078616
AF078617
AF078618
AF078619
AF078620
AF078621
AF078622
AF078623
AF078624
AF078625
AF078626
AF078627
AF078628
AF078629
AF078630
AF078631
AF078632
AF078633
AF078634
AF078635
AF078636
GM07283
GM
NIGMS NIH HHS
United States
Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
UNITED STATES
Proc Natl Acad Sci U S A
7505876
0027-8424
0
Bacterial Proteins
IM
S
Biochemistry. 1991 Jul 23;30(29):7142-53
1854726
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1988046
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2207096
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2231712
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2315699
Biochemistry. 1990 Mar 6;29(9):2403-8
2337607
Proteins. 1989;5(1):22-37
2664764
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2684274
J Mol Biol. 1989 Mar 20;206(2):397-406
2716053
Adv Protein Chem. 1988;39:191-234
3072868
J Mol Biol. 1988 Feb 5;199(3):525-37
3127592
Nature. 1988 Dec 15;336(6200):651-6
3200317
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3257756
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3464944
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518863
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6048539
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7108955
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7151796
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7408869
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7462208
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7618889
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7758464
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7877172
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8594554
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8611563
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8637847
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8688087
Protein Eng. 1996 Jan;9(1):27-36
9053899
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9144797
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9217266
Gene. 1997 Dec 31;205(1-2):309-16
9461405
Proc Natl Acad Sci U S A. 1992 May 1;89(9):3751-5
1570293
Nature. 1975 May 15;255(5505):256-9
1143325
J Theor Biol. 1975 Mar;50(1):167-83
1127956
Science. 1974 Sep 6;185(4154):862-4
4843792
Crit Rev Biochem Mol Biol. 1991;26(1):1-52
1678690
Acclimatization
Amino Acid Sequence
Amino Acid Substitution
Bacterial Proteins
chemistry
genetics
Methanococcus
genetics
metabolism
Molecular Sequence Data
Protein Conformation
Species Specificity
Temperature
PMC22336
NASA Discipline Exobiology
Non-NASA Center
Woese
C R
CR
U IL, Urbana
10101342
1999
04
15
1999
04
15
2007
11
15
0733-8627
17
1
1999
Feb
Emergency medicine clinics of North America
Emerg. Med. Clin. North Am.
Evaluation of the patient with extremity trauma: an evidence based approach.
77-95, viii
This article reviews relevant literature to provide evidence based guidelines for the evaluation of patients with extremity trauma in the emergency department. The development of clinical decision rules for extremity trauma in the ankle and knee, and guidelines for obtaining postreduction radiographs of shoulder dislocations and nursemaid's elbows are discussed.
Division of Emergency Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
Kaufman
D
D
Leung
J
J
eng
Journal Article
UNITED STATES
Emerg Med Clin North Am
8219565
0733-8627
IM
Ankle Injuries
etiology
radiography
therapy
Decision Support Techniques
Emergencies
Extremities
injuries
radiography
Fractures, Bone
etiology
radiography
therapy
Humans
Knee Injuries
etiology
radiography
therapy
Practice Guidelines as Topic
Shoulder Dislocation
etiology
radiography
therapy
10188493
1999
04
13
1999
04
13
2004
11
17
1354-5760
5
8
1998 Dec-1999 Jan
Nursing management (Harrow, London, England : 1994)
Nurs Manag (Harrow)
Women's health osteopathy: an alternative view.
6-9
Hyne
J
J
eng
Journal Article
ENGLAND
Nurs Manag (Harrow)
9433248
1354-5760
N
Female
Great Britain
Humans
Osteopathic Medicine
methods
State Medicine
Women's Health
10192114
1999
06
01
1999
06
01
2007
01
29
0031-7144
54
3
1999
Mar
Die Pharmazie
Pharmazie
Antimicrobial activity of some Nepalese medicinal plants.
232-4
Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany.
Rajbhandari
M
M
Schöpke
T
T
eng
Journal Article
Research Support, Non-U.S. Gov't
GERMANY
Pharmazie
9800766
0031-7144
0
Anti-Bacterial Agents
0
Plant Extracts
IM
Anti-Bacterial Agents
isolation & purification
pharmacology
Gram-Positive Bacteria
drug effects
Microbial Sensitivity Tests
Nepal
Plant Extracts
pharmacology
Plants, Medicinal
chemistry
10192115
1999
06
01
1999
06
01
2007
01
29
0031-7144
54
3
1999
Mar
Die Pharmazie
Pharmazie
Different kinetics of hydroquinone depletion in various medicinal plant tissue cultures producing arbutin.
234-5
Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
Jahodár
L
L
Dusková
J
J
Polásek
M
M
Papugová
P
P
eng
Journal Article
GERMANY
Pharmazie
9800766
0031-7144
0
Hydroquinones
497-76-7
Arbutin
IM
Arbutin
analysis
biosynthesis
Culture Techniques
Flow Injection Analysis
Hydroquinones
analysis
chemistry
Kinetics
Plants, Medicinal
metabolism
10331748
1999
06
01
1999
06
01
2009
11
11
0031-9023
79
5
1999
May
Physical therapy
Phys Ther
Looking for the Forrest.
454-5
Rothstein
J M
JM
eng
Editorial
UNITED STATES
Phys Ther
0022623
0031-9023
AIM
IM
Empathy
Humans
Knowledge
Physical Therapy Modalities
Professional-Patient Relations
Social Change
Violence
psychology
10331749
1999
06
01
1999
06
01
2009
11
11
0031-9023
79
5
1999
May
Physical therapy
Phys Ther
Effects of side lying on lung function in older individuals.
456-66
Body positioning exerts a strong effect on pulmonary function, but its effect on other components of the oxygen transport pathway are less well understood, especially the effects of side-lying positions. This study investigated the interrelationships between side-lying positions and indexes of lung function such as spirometry, alveolar diffusing capacity, and inhomogeneity of ventilation in older individuals.
Nineteen nonsmoking subjects (mean age=62.8 years, SD=6.8, range=50-74) with no history of cardiac or pulmonary disease were tested over 2 sessions. The test positions were sitting and left side lying in one session and sitting and right side lying in the other session. In each of the positions, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), single-breath pulmonary diffusing capacity (DLCO/VA), and the slope of phase III (DN2%/L) of the single-breath nitrogen washout test to determine inhomogeneity of ventilation were measured.
Compared with measurements obtained in the sitting position, FVC and FEV1 were decreased equally in the side-lying positions, but no change was observed in DLCO/VA or DN2%/L.
Side-lying positions resulted in decreases in FVC and FEV1, which is consistent with the well-documented effects of the supine position. These findings further support the need for prescriptive rather than routine body positioning of patients with risks of cardiopulmonary compromise and the need to use upright positions in which lung volumes and capacities are maximized.
Family Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Manning
F
F
Dean
E
E
Ross
J
J
Abboud
R T
RT
eng
Journal Article
Research Support, Non-U.S. Gov't
UNITED STATES
Phys Ther
0022623
0031-9023
AIM
IM
S
Aged
physiology
Breath Tests
Female
Forced Expiratory Volume
physiology
Heart Diseases
prevention & control
Humans
Lung Diseases
prevention & control
Male
Middle Aged
Posture
physiology
Predictive Value of Tests
Pulmonary Diffusing Capacity
physiology
Spirometry
Vital Capacity
physiology
10389168
1999
07
15
1999
07
15
2006
11
15
0869-8139
85
1
1999
Jan
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk
Ross Fiziol Zh Im I M Sechenova
[Ethanol modifies the ion selectivity of sodium channels in the rat sensory neurons].
110-8
Ethanol was shown to decrease the reversal potential of tetrodotoxin-resistant (TTXr) and TTX-sensitive channels in short-term culture of the dorsal root ganglion cells. The ethanol led to alterations in ionic selectivity of the TTXr channels (its shifting from the X-th Eisenmann selectivity sequence to the XI-th one). The data obtained suggest that the findings were due to selectivity filter modification because of disturbed hydrogen bounds in the channel macromolecule.
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Krylov
B V
BV
Vilin
Iu Iu
IuIu
Katina
I E
IE
Podzorova
S A
SA
rus
English Abstract
Journal Article
Etanol modifitsiruet ionnuiu izbiratel'nost' natrievykh kanalov sensornykh neĭronov krysy.
RUSSIA
Ross Fiziol Zh Im I M Sechenova
9715665
0869-8139
0
Cations
0
Sodium Channels
4368-28-9
Tetrodotoxin
64-17-5
Ethanol
IM
Animals
Cations
metabolism
Cells, Cultured
Ethanol
pharmacology
Ganglia, Spinal
cytology
Ion Channel Gating
Neurons, Afferent
drug effects
metabolism
Patch-Clamp Techniques
Rats
Rats, Wistar
Sodium Channels
drug effects
Tetrodotoxin
pharmacology
14796701
1951
12
01
2004
02
15
2008
11
21
0028-0836
166
4234
1950
Dec
23
Nature
Nature
Reduction by molecular hydrogen of acetoacetate to butyrate by butyric acid bacteria.
1077-8
COHEN
G N
GN
COHEN-BAZIRE
G
G
eng
Journal Article
Not Available
Nature
0410462
0028-0836
0
Acetoacetates
107-92-6
Butyric Acid
541-50-4
acetoacetic acid
OM
Acetoacetates
Bacteria
Butyric Acid
5120:27591:5:76:156
ACETOACETIC ACID
BACTERIA
BUTYRIC ACID
14817685
1951
12
01
2004
02
15
2010
01
25
47
52
1950
Dec
29
Svenska läkartidningen
Sven Lakartidn
[The beriberi heart].
3017-23
PALMBORG
G
G
und
Journal Article
Om beriberihjärta.
Not Available
Sven Lakartidn
0030130
OM
Beriberi
Heart Diseases
5120:49529:96:423
BERIBERI
HEART IN VARIOUS DISEASES
13072632
1953
12
01
2003
05
01
2009
11
11
217
2
1953
Jan
5
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol
[Pharmacology of phosphoric acid esters; diethylthiophosphoric acid ester of ethylthioglycol].
144-52
WIRTH
W
W
und
Journal Article
Zur Pharmakologie der Phosphorsäureester; diathylthiophosphorsäureester des Athylthioglykol Systox-Wirkstoff.
Not Available
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol
0054224
0
Insecticides
0
Phosphates
OM
Insecticides
Phosphates
5324:43336:331:494
INSECTICIDES
PHOSPHATES
13634534
1959
12
01
2000
07
01
2006
11
15
0014-2565
71
6
1958
Dec
31
Revista clínica española
Rev Clin Esp
[Physiopathology of phosphorus and calcium changes and of bone lesions in glomerular nephropathies].
365-77
LICHTWITZ
A
A
DE SEZE
S
S
PARLIER
R
R
HIOCO
D
D
BORDIER
P
P
STRAUSS
M
M
FERGOLA-MIRAVET
L
L
spa
Journal Article
Fisiopatología de las modificaciones fosfocálcicas y de las lesiones óseas en las nefropatías glomerulares.
Not Available
Rev Clin Esp
8608576
0014-2565
7440-70-2
Calcium
7723-14-0
Phosphorus
OM
Bone Diseases
physiology
Calcium
metabolism
Glomerulonephritis
physiology
Phosphorus
metabolism
5936:8365:92:105:226:416
BONE DISEASES/physiology
CALCIUM/metabolism
GLOMERULONEPHRITIS/physiology
PHOSPHORUS/metabolism
14177620
1964
11
01
1996
12
01
2006
11
15
0016-5662
68
1963
Dec
31
Gazzetta internazionale di medicina e chirurgia
Gazz Int Med Chir
[JEJUNAL BIOPSY AND LIPEMIA TOLERANCE TEST IN CIRRHOTIC PATIENTS].
SUPPL:4309-22
CESAREBASILE
R
R
GABBRIELLI
L
L
COLAVOLPE
V
V
RULLI
V
V
ita
Journal Article
BIOPSIA DIGIUNALE E LIPEMIA DA CARICO DEL CIRROTICO.
ITALY
Gazz Int Med Chir
0373000
0016-5662
0
Chylomicrons
0
Lipids
0
Lipoproteins
OM
Ascites
Chylomicrons
Diabetes Mellitus
Gastric Acidity Determination
Gastritis
Hepatitis A
Jaundice
Jejunum
Lipid Metabolism
Lipids
blood
Lipoproteins
Liver Cirrhosis
Malaria
Pathology
Pleurisy
Protein Deficiency
ASCITES
BLOOD LIPIDS
CHYLOMICRONS
DIABETES MELLITUS
GASTRIC ACIDITY DETERMINATION
GASTRITIS
HEPATITIS, INFECTIOUS
JAUNDICE
JEJUNUM
LIPID METABOLISM
LIPOPROTEINS
LIVER CIRRHOSIS
MALARIA
PATHOLOGY
PLEURISY
PROTEIN DEFICIENCY
14316043
1965
10
01
1996
12
01
2010
05
11
0042-0255
59
1965 Dec-1966 Jan
University of Toronto undergraduate dental journal
Univ Toronto Undergrad Dent J
THE RESPONSIBILITY OF THE DENTIST AND THE DENTAL PROFESSION WITH RESPECT TO JAW FRACTURES.
5-11
PHILLIPS
H
H
eng
Journal Article
CANADA
Univ Toronto Undergrad Dent J
7905911
0042-0255
D
OM
Dentists
Fracture Fixation
Fractures, Bone
Interprofessional Relations
Jaw
Mandibular Injuries
Maxillofacial Injuries
Practice Management, Dental
DENTISTS
FRACTURE FIXATION
FRACTURES
INTERPROFESSIONAL RELATIONS
JAW
MANDIBULAR INJURIES
MAXILLOFACIAL INJURIES
PRACTICE MANAGEMENT, DENTAL
14337379
1965
12
01
1996
12
01
2005
11
16
0002-9378
93
1965
Oct
1
American journal of obstetrics and gynecology
Am. J. Obstet. Gynecol.
SEROTONIN CONTENT OF HUMAN PLACENTA AND FETUS DURING PREGNANCY.
411-5
KOREN
Z
Z
PFEIFER
Y
Y
SULMAN
F G
FG
eng
Journal Article
UNITED STATES
Am J Obstet Gynecol
0370476
0002-9378
50-67-9
Serotonin
OM
Cesarean Section
Fetus
Histocytochemistry
Metabolism
Placenta
Pregnancy
Serotonin
ABORTION
CESAREAN SECTION
FETUS
HISTOCYTOCHEMISTRY
METABOLISM
PLACENTA
PREGNANCY
SEROTONIN
15611660
2005
03
01
2006
03
23
2006
11
15
1551-4005
4
1
2005
Jan
Cell cycle (Georgetown, Tex.)
Cell Cycle
Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.
3-5
Understanding the biological mechanisms underlying aging and cancer predisposition remains a fundamentally important goal in biomedicine. The generation of a PASG hypomorphic mutant mouse model shows that PASG, an SNF2 family member, is essential for properly maintaining normal DNA methylation and gene expression patterns. Disruption of PASG leads to decreased incorporation of BrdU, accumulation of senescence-associated tumor suppressor genes, and increased senescence-associated beta-galactosidase as well as age-related phenotypes. These observations demonstrate that PASG plays a critical role in maintenance of tissue homeostasis, normal growth and longevity.
Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sun
Lin-Quan
LQ
Arceci
Robert J
RJ
eng
Journal Article
2005
01
03
United States
Cell Cycle
101137841
1551-4005
59-14-3
Bromodeoxyuridine
9007-49-2
DNA
EC 2.1.1.-
Methyltransferases
EC 3.2.1.23
beta-Galactosidase
EC 3.6.1.-
DNA Helicases
EC 5.99.-
Hells protein, mouse
IM
Animals
Bromodeoxyuridine
metabolism
Cell Aging
genetics
Cell Cycle
genetics
physiology
Cell Proliferation
DNA
metabolism
DNA Helicases
antagonists & inhibitors
genetics
physiology
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Developmental
Homeostasis
genetics
physiology
Longevity
genetics
Methyltransferases
physiology
Mice
Mice, Mutant Strains
Mutation
beta-Galactosidase
metabolism
15611661
2005
03
01
2006
03
23
2009
11
19
1551-4005
4
1
2005
Jan
Cell cycle (Georgetown, Tex.)
Cell Cycle
TrkAIII. A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance.
8-9
Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation, differentiation and apoptosis. In cancer, TrkA frequently exhibits suppressor activity in nonmutated form and oncogenic activity upon mutation. Our identification of a novel hypoxia-regulated alternative TrkAIII splice variant, expressed by neural crest-derived neuroblastic tumors, that exhibits neuroblastoma tumor promoting activity, adds significantly to our understanding of potential TrkA involvement in cancer. Our observation that hypoxia, which characterizes the tumor micro-environment, stimulates alternative TrkAIII splicing, provides a way by which TrkA tumor suppressing signals may convert to tumor promoting signals during progression and is consistent with conservation and pathological subversion by neural crest-derived neuroblastic tumors of a mechanism of potential physiological importance to normal neural stem/neural crest progenitors.
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
Tacconelli
Antonella
A
Farina
Antonietta R
AR
Cappabianca
Lucia
L
Gulino
Alberto
A
Mackay
Andrew R
AR
eng
Journal Article
2005
01
05
United States
Cell Cycle
101137841
1551-4005
0
DNA, Neoplasm
EC 2.7.10.1
Receptor, trkA
IM
Alternative Splicing
Cell Differentiation
genetics
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation
DNA, Neoplasm
genetics
Gene Expression Regulation, Neoplastic
Genetic Variation
Humans
Neoplastic Stem Cells
pathology
physiology
Neural Crest
cytology
physiology
Neuroblastoma
genetics
pathology
physiopathology
Receptor, trkA
genetics
physiology
Signal Transduction
genetics
15611667
2005
03
01
2006
03
23
1551-4005
4
1
2005
Jan
Cell cycle (Georgetown, Tex.)
Cell Cycle
Replication timing of human chromosome 6.
172-6
Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms. A replication timing map of the human genome has already been published at a 1Mb resolution. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Woodfine
Kathryn
K
Beare
David M
DM
Ichimura
Koichi
K
Debernardi
Silvana
S
Mungall
Andrew J
AJ
Fiegler
Heike
H
Collins
V Peter
VP
Carter
Nigel P
NP
Dunham
Ian
I
eng
Journal Article
2005
01
05
United States
Cell Cycle
101137841
1551-4005
71-30-7
Cytosine
73-40-5
Guanine
9007-49-2
DNA
IM
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 6
genetics
physiology
Cytosine
analysis
DNA
chemistry
genetics
DNA Repeat Expansion
DNA Replication Timing
Epigenesis, Genetic
G1 Phase
genetics
physiology
Gene Expression Regulation
Guanine
analysis
Humans
Major Histocompatibility Complex
genetics
Oligonucleotide Array Sequence Analysis
methods
S Phase
genetics
physiology
Transcription, Genetic
15739502
2005
03
02
2010
04
15
1000-8713
15
5
1997
Sep
Se pu = Chinese journal of chromatography / Zhongguo hua xue hui
Se Pu
[The determination of olaquindox in feeds by HPLC].
440-1
A liquid chromatographic procedure for the determination of olaquindox in feeds is described. Chromatography was performed on a PC8-10/S2504 (4.0 mm i.d. x 250 mm, 10 microm, Shimadzu Co.) column at 30 degrees C by using a mobile phase of methanol:water (20:80, V/V ) with a flow rate of 0.8 mL/min and UV detection at 260 nm. Acetanilide was used as internal standard. Olaquindox was extracted with dimethylformamide (DMF) from the feeds. The average recoveries of olaquindox were 98.58%-101.63% and the relative standard deviations were 2.67%-4.25%. The method is simple, rapid, reliable and inexpensive.
Institute of Applied Chemistry, Nanchang University, Nanchang, 330047.
Li
L
L
Qiu
S
S
chi
English Abstract
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
China
Se Pu
9424804
1000-8713
0
Food Additives
0
Quinoxalines
23696-28-8
olaquindox
IM
Animal Feed
analysis
Chromatography, High Pressure Liquid
methods
Food Additives
analysis
Quinoxalines
analysis
15810377
2005
04
06
2010
05
21
1000-0593
17
5
1997
Oct
Guang pu xue yu guang pu fen xi = Guang pu
Guang Pu Xue Yu Guang Pu Fen Xi
[Study on cleavage mechanisms of dimer (t-Bu)2NO in several solvent phases].
124-7
In this paper, we studied the cleavage products of dimer t-BuNO in aqueous and organic solutions using method of 1HNMR and UV-Vis, analyzed the reactive kinetics, put forward that dimer (t-Bu)2NO homolytically cleavaged in nonpolar organic solution, and that dimer (t-Bu)2NO homolytically and heterolyticall cleavaged in a competitive manner in polar aqueous solution.
Cancer Research Institute, Hunan Medical University, Changsha.
Ma
X
X
Tang
J
J
chi
English Abstract
Journal Article
China
Guang Pu Xue Yu Guang Pu Fen Xi
9424805
1000-0593
15968009
2005
06
21
2005
06
27
2007
11
14
1539-3704
142
12 Pt 1
2005
Jun
21
Annals of internal medicine
Ann. Intern. Med.
The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial.
953-62
There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE).
To evaluate the effect of hormone replacement therapy (HRT) on disease activity in postmenopausal women with SLE.
Randomized, double-blind, placebo-controlled noninferiority trial conducted from March 1996 to June 2002.
16 university-affiliated rheumatology clinics or practices in 11 U.S. states.
351 menopausal patients (mean age, 50 years) with inactive (81.5%) or stable-active (18.5%) SLE. Interventions: 12 months of treatment with active drug (0.625 mg of conjugated estrogen daily, plus 5 mg of medroxyprogesterone for 12 days per month) or placebo. The 12-month follow-up rate was 82% for the HRT group and 87% for the placebo group.
The primary end point was occurrence of a severe flare as defined by Safety of Estrogens in Lupus Erythematosus, National Assessment-Systemic Lupus Erythematosus Disease Activity Index composite.
Severe flare was rare in both treatment groups: The 12-month severe flare rate was 0.081 for the HRT group and 0.049 for the placebo group, yielding an estimated difference of 0.033 (P = 0.23). The upper limit of the 1-sided 95% CI for the treatment difference was 0.078, within the prespecified margin of 9% for noninferiority. Mild to moderate flares were significantly increased in the HRT group: 1.14 flares/person-year for HRT and 0.86 flare/person-year for placebo (relative risk, 1.34; P = 0.01). The probability of any type of flare by 12 months was 0.64 for the HRT group and 0.51 for the placebo group (P = 0.01). In the HRT group, there were 1 death, 1 stroke, 2 cases of deep venous thrombosis, and 1 case of thrombosis in an arteriovenous graft; in the placebo group, 1 patient developed deep venous thrombosis.
Findings are not generalizable to women with high-titer anticardiolipin antibodies, lupus anticoagulant, or previous thrombosis.
Adding a short course of HRT is associated with a small risk for increasing the natural flare rate of lupus. Most of these flares are mild to moderate. The benefits of HRT can be balanced against the risk for flare because HRT did not significantly increase the risk for severe flare compared with placebo.
Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA. jill.buyon@nyumc.org
Buyon
Jill P
JP
Petri
Michelle A
MA
Kim
Mimi Y
MY
Kalunian
Kenneth C
KC
Grossman
Jennifer
J
Hahn
Bevra H
BH
Merrill
Joan T
JT
Sammaritano
Lisa
L
Lockshin
Michael
M
Alarcón
Graciela S
GS
Manzi
Susan
S
Belmont
H Michael
HM
Askanase
Anca D
AD
Sigler
Lisa
L
Dooley
Mary Anne
MA
Von Feldt
Joan
J
McCune
W Joseph
WJ
Friedman
Alan
A
Wachs
Jane
J
Cronin
Mary
M
Hearth-Holmes
Michelene
M
Tan
Mark
M
Licciardi
Frederick
F
eng
ClinicalTrials.gov
NCT00000419
AR 43727
AR
NIAMS NIH HHS
United States
M01 RR00052
RR
NCRR NIH HHS
United States
M01 RR00096
RR
NCRR NIH HHS
United States
U01 AR42540
AR
NIAMS NIH HHS
United States
Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
United States
Ann Intern Med
0372351
0003-4819
0
Estrogens, Conjugated (USP)
520-85-4
Medroxyprogesterone
AIM
IM
Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1014-5
15968016
Ann Intern Med. 2005 Jun 21;142(12 Pt 1):I22
15968006
Adolescent
Aged
Aged, 80 and over
Double-Blind Method
Estrogen Replacement Therapy
adverse effects
Estrogens, Conjugated (USP)
therapeutic use
Female
Follow-Up Studies
Humans
Lupus Erythematosus, Systemic
physiopathology
Medroxyprogesterone
therapeutic use
Middle Aged
Postmenopause
Risk Factors
16779244
2006
06
16
2007
02
15
2009
11
18
1942-597X
2005
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
AMIA Annu Symp Proc
MeSH Speller + askMEDLINE: auto-completes MeSH terms then searches MEDLINE/PubMed via free-text, natural language queries.
957
Medical terminology is challenging even for healthcare personnel. Spelling errors can make searching MEDLINE/PubMed ineffective. We developed a utility that provides MeSH term and Specialist Lexicon Vocabulary suggestions as it is typed on a search page. The correctly spelled term can be incorporated into a free-text, natural language search or used as a clinical queries search.
Office of High Performance Computing and Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, Maryland 20894, USA.
Fontelo
Paul
P
Liu
Fang
F
Ackerman
Michael
M
eng
NIH0010182610
PHS HHS
United States
Journal Article
United States
AMIA Annu Symp Proc
101209213
1559-4076
IM
J Med Internet Res. 2003 Dec 11;5(4):e31
14713659
JAMA. 1998 Oct 21;280(15):1336-8
9794314
Information Storage and Retrieval
methods
Medical Subject Headings
Natural Language Processing
PubMed
PMC1513542
16776646
2006
06
16
2006
08
09
2008
11
21
0248-4900
98
7
2006
Jul
Biology of the cell / under the auspices of the European Cell Biology Organization
Biol. Cell
Books for free? How can this be? - A PubMed resource you may be overlooking.
439-43
The NCBI (National Center for Biotechnology Information) at the National Institutes of Health collects a wide range of molecular biological data, and develops tools and databases to analyse and disseminate this information. Many life scientists are familiar with the website maintained by the NCBI (http://www.ncbi.nlm.nih.gov), because they use it to search GenBank for homologues of their genes of interest or to search the PubMed database for scientific literature of interest. There is also a database called the Bookshelf that includes searchable popular life science textbooks, medical and research reference books and NCBI reference materials. The Bookshelf can be useful for researchers and educators to find basic biological information. This article includes a representative list of the resources currently available on the Bookshelf, as well as instructions on how to access the information in these resources.
Department of Biology, The Catholic University of America, Washington, DC 20064, USA. corsi@cua.edu
Corsi
Ann K
AK
eng
Journal Article
England
Biol Cell
8108529
0248-4900
IM
Biological Science Disciplines
Books
Humans
Internet
National Library of Medicine (U.S.)
PubMed
Reference Books
Reference Books, Medical
Textbooks as Topic
United States
16888359
2006
08
04
2006
09
28
2009
11
18
1064-3745
338
2006
Methods in molecular biology (Clifton, N.J.)
Methods Mol. Biol.
Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*.
175-90
The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) has emerged as the leading fully public repository for gene expression data. This chapter describes how to use Web-based interfaces, applications, and graphics to effectively explore, visualize, and interpret the hundreds of microarray studies and millions of gene expression patterns stored in GEO. Data can be examined from both experiment-centric and gene-centric perspectives using user-friendly tools that do not require specialized expertise in microarray analysis or time-consuming download of massive data sets. The GEO database is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.
Barrett
Tanya
T
Edgar
Ron
R
eng
Journal Article
United States
Methods Mol Biol
9214969
1064-3745
IM
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13618-23
15353598
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W213-6
15215383
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
11752295
Science. 2003 Jun 13;300(5626):1749-51
12805549
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D562-6
15608262
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D39-45
15608222
PLoS Biol. 2004 Dec;2(12):e427
15562319
Methods Enzymol. 1996;266:141-62
8743683
J Mol Biol. 1990 Oct 5;215(3):403-10
2231712
Algorithms
Animals
Cluster Analysis
Data Interpretation, Statistical
Databases, Genetic
Gene Expression Profiling
statistics & numerical data
Humans
Information Storage and Retrieval
Internet
National Library of Medicine (U.S.)
Oligonucleotide Array Sequence Analysis
statistics & numerical data
Software
United States
NIHMS12705
PMC1619899
16923641
2006
08
22
2007
01
25
0803-9488
60
4
2006
Nordic journal of psychiatry
Nord J Psychiatry
The use of PubMed/Medline in psychiatry. 3: Searching PubMed.
310-5
This paper is the third in a series of three, intended as a tutorial in the use of PubMed/Medline for an inexperienced user. The papers have the following contents: I--a description of NLM, Medline, PubMed and the system of Medical Subject Headings (MeSH), which form the basis for the indexing of scientific articles, books and other items at NLM. II--A description and a tutorial of the PubMed search window. III--The present article deals mainly with the searching for references in PubMed. Ways of restricting and concentrating the search are presented, and exercises are proposed. A reader may also find guidance for a search for medical books in the NLM Catalog, and in the use of tools like Related Articles, Bookshelf, and Index. With eating disorders as an example, more information is presented on the use of MeSH terms.
Division of Psychiatry, Department of Clinical Neuroscience, Lund University, Sweden. sten.theander@med.lu.se
Theander
Sten S
SS
eng
Journal Article
Research Support, Non-U.S. Gov't
Norway
Nord J Psychiatry
100927567
0803-9488
IM
MEDLINE
Medical Subject Headings
Psychiatry
PubMed
16949478
2006
09
04
2006
09
21
1558-3597
48
5
2006
Sep
5
Journal of the American College of Cardiology
J. Am. Coll. Cardiol.
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death).
e247-346
European Heart Rhythm Association
Heart Rhythm Society
Zipes
Douglas P
DP
Camm
A John
AJ
Borggrefe
Martin
M
Buxton
Alfred E
AE
Chaitman
Bernard
B
Fromer
Martin
M
Gregoratos
Gabriel
G
Klein
George
G
Moss
Arthur J
AJ
Myerburg
Robert J
RJ
Priori
Silvia G
SG
Quinones
Miguel A
MA
Roden
Dan M
DM
Silka
Michael J
MJ
Tracy
Cynthia
C
Smith
Sidney C
SC
Jr
Jacobs
Alice K
AK
Adams
Cynthia D
CD
Antman
Elliott M
EM
Anderson
Jeffrey L
JL
Hunt
Sharon A
SA
Halperin
Jonathan L
JL
Nishimura
Rick
R
Ornato
Joseph P
JP
Page
Richard L
RL
Riegel
Barbara
B
Priori
Silvia G
SG
Blanc
Jean-Jacques
JJ
Budaj
Andrzej
A
Camm
A John
AJ
Dean
Veronica
V
Deckers
Jaap W
JW
Despres
Catherine
C
Dickstein
Kenneth
K
Lekakis
John
J
McGregor
Keith
K
Metra
Marco
M
Morais
Joao
J
Osterspey
Ady
A
Tamargo
Juan Luis
JL
Zamorano
José Luis
JL
American College of Cardiology
American Heart Association Task Force
European Society of Cardiology Committee for Practice Guidelines
eng
Journal Article
Practice Guideline
United States
J Am Coll Cardiol
8301365
0735-1097
0
Anti-Arrhythmia Agents
AIM
IM
Anti-Arrhythmia Agents
therapeutic use
Cardiac Output, Low
Cardiomyopathies
complications
Catheter Ablation
Death, Sudden, Cardiac
etiology
prevention & control
Defibrillators, Implantable
Electrocardiography
Heart Arrest
etiology
therapy
Heart Function Tests
Humans
Tachycardia, Ventricular
complications
drug therapy
physiopathology
Ventricular Fibrillation
complications
drug therapy
physiopathology
17059514
2006
10
24
2007
05
07
0269-2813
24
9
2006
Nov
1
Alimentary pharmacology & therapeutics
Aliment. Pharmacol. Ther.
Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: A randomized-controlled trial.
1333-40
Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative therapy is needed for patients intolerant or resistant to thiopurines.
To evaluate the effectiveness of home enteral nutrition as a maintenance therapy regimen in which half of the daily calorie requirement is provided by an elemental diet and the remaining half by a free diet. We refer to this home enteral nutrition therapy as 'half elemental diet'.
Between 2002 and 2005, 51 patients in remission from two hospitals were randomly assigned to a half elemental diet group (n = 26) or a free diet group (n = 25). The primary outcome measure of this study was the occurrence of relapse over the 2-year period.
The relapse rate in the half elemental diet group was significantly lower [34.6% vs. 64.0%; multivariate hazard ratio 0.40 (95% CI: 0.16-0.98)] than that in the free diet group after a mean follow-up of 11.9 months. Compliance was similar in the two groups. No adverse event occurred in any of the patients throughout the study.
This randomized-controlled trial shows the effectiveness of an half elemental diet, which is a promising maintenance therapy for Crohn's disease patients.
Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. stakagi@int3.med.tohoku.ac.jp
Takagi
S
S
Utsunomiya
K
K
Kuriyama
S
S
Yokoyama
H
H
Takahashi
S
S
Iwabuchi
M
M
Takahashi
H
H
Takahashi
S
S
Kinouchi
Y
Y
Hiwatashi
N
N
Funayama
Y
Y
Sasaki
I
I
Tsuji
I
I
Shimosegawa
T
T
eng
Journal Article
Randomized Controlled Trial
England
Aliment Pharmacol Ther
8707234
0269-2813
IM
Adult
Crohn Disease
diet therapy
Enteral Nutrition
methods
Female
Follow-Up Studies
Food, Formulated
Humans
Male
Parenteral Nutrition
methods
Recurrence
Treatment Outcome
17712873
2007
08
21
2007
08
22
2007
10
01
1432-2218
21
6
2007
Jun
Surgical endoscopy
Surg Endosc
Crura ultrastructural alterations in patients with hiatal hernia: a pilot study.
907-11
Unit of Surgical Digestive Physiopathology, Second University of Naples, via Pansini 5, I-80131 Naples, Italy. landino.fei@tin.it
Fei
L
L
del Genio
G
G
Brusciano
L
L
Esposito
V
V
Cuttitta
D
D
Pizza
F
F
Rossetti
G
G
Trapani
V
V
Filippone
G
G
Moccia
F
F
Francesco
M
M
del Genio
A
A
eng
Journal Article
Germany
Surg Endosc
8806653
0930-2794
IM
Surg Endosc. 2007 Aug;21(8):1473
Francesco, M [removed]; Moccia, F [added]
Adult
Biopsy
Connective Tissue
ultrastructure
Diaphragm
abnormalities
ultrastructure
Female
Gastroesophageal Reflux
etiology
surgery
Hernia, Hiatal
etiology
surgery
Humans
Male
Microscopy, Electron, Transmission
Middle Aged
Muscle, Skeletal
ultrastructure
Recurrence
17713168
2007
08
23
2007
10
19
2007
11
30
1359-6535
12
5
2007
Antiviral therapy
Antivir. Ther. (Lond.)
Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort study.
835-9
A major barrier to successful viral suppression in HIV type 1 (HIV-1)-infected individuals is the emergence of virus resistant to antiretroviral drugs. We explored the evolution of genotypic drug resistance prevalence in treatment-failing patients from 1999 to 2005 in a clinical cohort.
Prevalence of major International AIDS Society-USA HIV-1 drug resistance mutations was measured over calendar years in a population with treatment failure and undergoing resistance testing. Predictors of the presence of resistance mutations were analysed by logistic regression.
Significant reductions of the prevalence of resistance to all three drug classes examined were observed. This was accompanied by a reduction in the proportion of treatment-failing patients. Independent predictors of drug resistance were the earlier calendar year, prior use of suboptimal nucleoside analogue therapy, male sex and higher CD4 levels at testing.
In a single clinical cohort, we observed a decrease in the prevalence of resistance to all three examined antiretroviral drug classes over time. If this finding is confirmed in multicentre cohorts it may translate into reduced transmission of drug-resistant virus from treated patients.
Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. simona.digiambenedetto@rm.unicatt.it
Di Giambenedetto
Simona
S
Bracciale
Laura
L
Colafigli
Manuela
M
Colatigli
Manuela
M
Cattani
Paola
P
Pinnetti
Carmen
C
Pannetti
Carmen
C
Bacarelli
Alessandro
A
Prosperi
Mattia
M
Fadda
Giovanni
G
Cauda
Roberto
R
De Luca
Andrea
A
eng
Journal Article
Research Support, Non-U.S. Gov't
England
Antivir Ther
9815705
1359-6535
0
Anti-HIV Agents
0
RNA, Viral
IM
Antivir Ther. 2007;12(7):1145
Colatigli, Manuela [corrected to Colafigli, Manuela; Cattani, Paola [added]; Pannetti, Carmen [corrected to Pinnetti, Carmen]
Adult
Anti-HIV Agents
therapeutic use
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Cohort Studies
Drug Resistance, Viral
genetics
Female
Genotype
HIV Infections
drug therapy
epidemiology
immunology
virology
HIV-1
genetics
Humans
Logistic Models
Male
Middle Aged
Mutation
Odds Ratio
Population Surveillance
Prevalence
RNA, Viral
Risk Assessment
Risk Factors
Sex Factors
Time Factors
Treatment Failure
17823161
2007
09
07
2007
09
17
2010
09
09
1468-5833
335
7618
2007
Sep
8
BMJ (Clinical research ed.)
BMJ
Agency warns about dosing error for amphotericin after patients with cancer die.
467
Hawkes
Nigel
N
eng
News
England
BMJ
8900488
0959-535X
0
Antifungal Agents
1397-89-3
Amphotericin B
AIM
IM
BMJ. 2008 Jan 12;336(7635). doi: 10.1136/bmj.39454.454676.AD
Adult
Amphotericin B
poisoning
Antifungal Agents
poisoning
England
Humans
Male
Medication Errors
Mycoses
drug therapy
Neoplasms
complications
PMC1971151
18122624
1949
12
01
2007
12
27
0891-3633
59 (1 vol.)
1947-1948
Transactions of the Southern Surgical Association. Southern Surgical Association (U.S.)
Trans South Surg Assoc
Mesenteric vascular occlusion.
136-55
RIVES
J D
JD
STRUG
L H
LH
ESSRIG
I M
IM
eng
Journal Article
Not Available
Trans South Surg Assoc
20930080R
0891-3633
OM
4916:397a1
MESENTERY/occlusion
18243949
2008
02
04
0278-0062
4
1
1985
IEEE transactions on medical imaging
IEEE Trans Med Imaging
Electrophoretic recording of electronically stored radiographs.
39-43
Continuous tone hard copies of electronically stored radiographs are recorded on transparent film with a silverless conductive coating by electrophoretic deposition of toner particles. A stationary experimental print head with a row of 320 electrodes (eight electrodes per mm) was employed. The performance of the recording process with regard to the most important parameters, i.e., toner concentration, width of the gap between recording medium and electrodes, recording voltage, and speed will be described. The process exhibits continuous tone characteristics, because the optical density can be varied continuously by the recording voltage. The image resolution which can be achieved is characterized by a modulation transfer function.
Hinz
H D
HD
Lobl
H
H
eng
Journal Article
United States
IEEE Trans Med Imaging
8310780
0278-0062
18311089
2008
03
03
1091-0220
12
3
2008
Mar
Mayo Clinic women's healthsource
Mayo Clin Womens Healthsource
Cancer death rates have fallen faster since 2002.
3
eng
Journal Article
United States
Mayo Clin Womens Healthsource
9891120
1091-0220
K
17926191
2008
03
13
2008
04
09
2009
11
19
1042-8194
48
11
2007
Nov
Leukemia & lymphoma
Leuk. Lymphoma
Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.
2145-51
AML with inv(3)/t(3;3) are generally considered of having a poor prognosis. For further insight in this rare entity the outcome of 65 inv(3)/t(3;3) positive AML cases were examined with special emphasis o n patient a nd disease related factors at diagnosis. Survival data were available from 35 patients. A hematological CR was achieved in 16/35 patients (46%). Eight patients (50%) relapsed. The median duration of remission was 177 days. Probability of OS was 23% at 2 years. Advanced age and high initial WBC count were associated with shorter OS (p = 0.021 and p = 0.005, respectively). Loss of chromosome 7 was the most frequent additional aberration (n = 34; 52%), followed complex aberrant aberrations (n = 5). Cases with monosomy 7 or the presence of FLT3-length mutations (FLT3-LM)--detected in 13% of cases--were not associated with an even more inferior outcome. Allogeneic stem cell translplantation, performed in 12 cases, resulted in a probability of OS of 62% at 2 years. Our data (1) confirm that inv(3)/t(3;3) AML has a poor prognosis (2) show that age and initial WBC are risk factors for prognosis; (3) suggest that this group may benefit from allogeneic stem cell transplantation.
Medical Department III, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany. martin.weisser@gmx.de
Weisser
Martin
M
Haferlach
Claudia
C
Haferlach
Torsten
T
Schnittger
Susanne
S
eng
Evaluation Studies
Journal Article
England
Leuk Lymphoma
9007422
1026-8022
10540-29-1
Tamoxifen
125-84-8
Aminoglutethimide
147-94-4
Cytarabine
17230-88-5
Danazol
65271-80-9
Mitoxantrone
MAC chemotherapy protocol
TAD protocol
IM
Leuk Lymphoma. 2007 Nov;48(11):2096-7
17990175
Adult
Age Factors
Aged
Aged, 80 and over
Aminoglutethimide
therapeutic use
Antineoplastic Combined Chemotherapy Protocols
therapeutic use
Chromosome Inversion
Chromosomes, Human, Pair 3
Cohort Studies
Cytarabine
therapeutic use
Danazol
therapeutic use
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
Humans
Karyotyping
Leukemia, Myeloid, Acute
diagnosis
genetics
mortality
therapy
Leukocyte Count
Male
Middle Aged
Mitoxantrone
therapeutic use
Prognosis
Survival Analysis
Tamoxifen
therapeutic use
Translocation, Genetic
18719013
2008
08
22
2008
09
02
2009
11
18
1468-5833
337
2008
BMJ (Clinical research ed.)
BMJ
Health related quality of life after combined hormone replacement therapy: randomised controlled trial.
a1190
10.1136/bmj.a1190
337/aug21_2/a1190
To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life.
Randomised placebo controlled double blind trial.
General practices in United Kingdom (384), Australia (94), and New Zealand (24).
Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were randomised to combined oestrogen and progestogen (n=1862) or placebo (n=1859). Data on health related quality of life at one year were available from 1043 and 1087 women, respectively.
Conjugated equine oestrogen 0.625 mg plus medroxyprogesterone acetate 2.5/5.0 mg or matched placebo orally daily for one year.
Health related quality of life and psychological wellbeing as measured by the women's health questionnaire. Changes in emotional and physical menopausal symptoms as measured by a symptoms questionnaire and depression by the Centre for Epidemiological Studies depression scale (CES-D). Overall health related quality of life and overall quality of life as measured by the European quality of life instrument (EuroQol) and visual analogue scale, respectively.
After one year small but significant improvements were observed in three of nine components of the women's health questionnaire for those taking combined HRT compared with those taking placebo: vasomotor symptoms (P<0.001), sexual functioning (P<0.001), and sleep problems (P<0.001). Significantly fewer women in the combined HRT group reported hot flushes (P<0.001), night sweats (P<0.001), aching joints and muscles (P=0.001), insomnia (P<0.001), and vaginal dryness (P<0.001) than in the placebo group, but greater proportions reported breast tenderness (P<0.001) or vaginal discharge (P<0.001). Hot flushes were experienced in the combined HRT and placebo groups by 30% and 29% at trial entry and 9% and 25% at one year, respectively. No significant differences in other menopausal symptoms, depression, or overall quality of life were observed at one year.
Combined HRT started many years after the menopause can improve health related quality of life.
ISRCTN 63718836.
MRC General Practice Research Framework, Stephenson House, London NW1 2ND.
Welton
Amanda J
AJ
Vickers
Madge R
MR
Kim
Joseph
J
Ford
Deborah
D
Lawton
Beverley A
BA
MacLennan
Alastair H
AH
Meredith
Sarah K
SK
Martin
Jeannett
J
Meade
Tom W
TW
WISDOM team
eng
ISRCTN
ISRCTN63718836
British Heart Foundation
United Kingdom
Department of Health
United Kingdom
Medical Research Council
United Kingdom
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
2008
08
21
England
BMJ
8900488
0959-535X
0
Estrogens
0
Progestins
AIM
IM
Biol Psychiatry. 2004 Feb 15;55(4):406-12
14960294
N Engl J Med. 2003 May 8;348(19):1839-54
12642637
Climacteric. 2002 Dec;5(4):317-25
12626209
Arch Intern Med. 2003 Jan 27;163(2):205-9
12546611
Menopause. 2003 Jan-Feb;10(1):4-5
12544670
JAMA. 2002 Jul 17;288(3):321-33
12117397
JAMA. 2002 Feb 6;287(5):591-7
11829697
Arch Gen Psychiatry. 2001 Jun;58(6):529-34
11386980
Fertil Steril. 2001 Jun;75(6):1080-7
11384630
Am J Obstet Gynecol. 2000 Aug;183(2):414-20
10942479
J Allergy Clin Immunol. 1998 Jul;102(1):16-7
9679842
Fertil Steril. 2005 Mar;83(3):558-66
15749481
Climacteric. 2005 Mar;8(1):49-55
15804731
BMJ. 2004 Feb 14;328(7436):371
14962874
Qual Life Res. 2004 Mar;13(2):311-20
15085903
J Gen Intern Med. 2004 Jul;19(7):791-804
15209595
Arch Intern Med. 2005 Apr 25;165(8):863-7
15851636
Am J Psychiatry. 1983 Jan;140(1):41-6
6847983
BMJ. 1993 Oct 2;307(6908):836-40
8401125
Decubitus. 1993 Sep;6(5):56-8
8286021
Annu Rev Public Health. 1994;15:535-59
8054098
Soc Sci Med. 1994 Dec;39(11):1537-44
7817218
Am J Obstet Gynecol. 1994 Feb;170(2):618-24
7509570
Support Care Cancer. 1995 Jan;3(1):11-22
7697298
Qual Life Res. 1996 Oct;5(5):469-80
8973126
Horm Behav. 1996 Sep;30(3):244-50
8918680
Br J Obstet Gynaecol. 1997 Oct;104(10):1191-5
9332999
Stroke. 1997 Oct;28(10):1876-82
9341688
Med Care. 1997 Nov;35(11):1109-18
9366890
Stroke. 1998 Jan;29(1):63-8
9445330
Menopause. 2004 Sep-Oct;11(5):508-18
15356403
Health Qual Life Outcomes. 2003;1:24
12848895
Neurology. 2007 Sep 25;69(13):1322-30
17893293
JAMA. 2005 Jul 13;294(2):183-93
16014592
Arch Intern Med. 2005 Sep 26;165(17):1976-86
16186467
Neurobiol Aging. 2006 Jan;27(1):141-9
16298249
Horm Behav. 2006 Apr;49(4):441-9
16257405
N Engl J Med. 2006 Apr 6;354(14):1497-506
16598046
Hypertension. 2006 May;47(5):833-9
16585410
BMC Womens Health. 2007;7:2
17324282
Climacteric. 2007 Jun;10(3):181-94
17487645
BMJ. 2007 Aug 4;335(7613):239
17626056
BMJ. 2009;338:a2597
19139137
BMJ. 2008;337:a1494
18768558
Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):136-7
19229231
Aged
Double-Blind Method
Drug Therapy, Combination
Estrogens
administration & dosage
Female
Health Status
Hormone Replacement Therapy
methods
Humans
Middle Aged
Postmenopause
psychology
Progestins
administration & dosage
Prognosis
Quality of Life
Questionnaires
Women's Health
PMC2518695
Abdalla
M
M
DeStavola
B L
BL
Allen
P
P
Allen
H
H
Bastick
R
R
Brown
H
H
Foulger
K
K
Fox
S
S
Glynn
V
V
Hall
A
A
Hand
L
L
Hill
A
A
Leathem
C
C
Mackinnon
W
W
Marshall
E
E
Williams
A
A
Collins N
N
N
O'Conner
B
B
Darbyshire
J H
JH
Ghali
M
M
Furness
P
P
Islam
M Z
MZ
Harrild
K
K
Knott
C
C
Taylor
L
L
Walgrove
M A
MA
Wilkes
H C
HC
Zhu
C-Q
CQ
Zuhrie
S R
SR
Griffith
E
E
Ryan
P
P
Komesaroff
P
P
Marley
J
J
Paine
B J
BJ
Stocks
N P
NP
Dowell
A
A
Rose
S
S
18941263
2008
10
22
1833-3575
37
3
2008
The HIM journal
HIM J
Issues in the measurement of social determinants of health.
26-32
This article focuses on the measurement of the social determinants of health, and specifically on issues relating to two key variables relevant to the analysis of public health information: poverty and inequality. Although the paper has been written from the perspective of economics, the discipline of the two authors, it is also of relevance to researchers in other disciplines. It is argued that there is a need to ensure that, when considering measurement in this largely neglected area of research, sufficient thought is given to the relationships that are being examined or assessed. We argue further that any attempt at measurement in this area must take into account the historical backdrop and the complex nature of the relationships between these key variables.
Curtin University of Technology, Perth, Western Australia. g.mooney@curtin.edu.au
Mooney
Gavin
G
Fohtung
Nubong G
NG
eng
Journal Article
Australia
HIM J
101122643
1833-3583
H
18964660
2008
10
30
0039-9140
35
12
1988
Dec
Talanta
Talanta
Multiparametric curve fitting-XIII Reliability of formation constants determined by analysis of potentiometric titration data.
981-91
The formation (protonation) constants log K(i), of the acid H(j)L are determined by regression analysis of potentiometric titration data when common parameters (log K(i), i = 1,..., j) and group parameters (E(0)', L(0), H(T)) are refined. The influence of three kinds of error on the protonation constants has been investigated: error from the strategy of minimization, random error, and error from uncertain estimates of group parameters. An analysis of variance of the log K(i), matrix was made for 7 identical titrations and 8 computational strategies, or of 7 identical titrations and 8 different options of group parameters to be refined. The influence of the standard potential E(0) of the glass-electrode cell on the systematic error in log K is greater than that of the acid concentration (L(0)) or the concentration of titrant used (H(T)). The ill-conditioned group parameters should be refined together with the common parameters (K(i)), otherwise the estimates of log K(i), are not accurate enough. Two ways of calibrating the glass electrode cell were compared. Internal calibration (performed during titration) was more accurate than external calibration done separately. Of the programs tested ESAB and ACBA are the most powerful because they permit refinement of group parameters and internal calibration. Citric acid was chosen as model substance.
Department of Analytical Chemistry, College of Chemical Technology, CS-532 10 Pardubice, Czechoslovakia.
Meloun
M
M
Bartos
M
M
Högfeldt
E
E
eng
Journal Article
England
Talanta
2984816R
0039-9140
19771122
2009
09
22
2009
12
11
0146-9592
15
24
1990
Dec
15
Optics letters
Opt Lett
Ultrashort-laser-pulse amplification in a XeF[C --> A] excimer amplifier.
1461-3
Tunable blue-green subpicosecond laser pulses have been amplified in an electron-beam-pumped XeF(C --> A) excimer amplifier. Small-signal gains of 3.5% cm(-1) were measured using a 50-cm active gain length. At output energy densities as high as 170 mJ/cm(2), only a small degree of saturation occurred, resulting in a gain of 2.5% cm(-1).
Department of Electrical and Computer Engineering, Rice University, P.O. Box 1892, Houston, Texas 77251, USA.
Sharp
T E
TE
Hofmann
T
T
Dane
C B
CB
Wilson
W L
WL
Jr
Tittel
F K
FK
Wisoff
P J
PJ
Szabó
G
G
eng
Journal Article
United States
Opt Lett
7708433
0146-9592
20405411
2010
04
20
1828-1427
44
1
2008 Jan-Mar
Veterinaria italiana
Vet. Ital.
Long distance animal transport: the way forward.
43-7
Too often, the issue of animal welfare during transport is the subject of emotional debates. For farmers within the International Federation of Agricultural Producers, it is important that the economic, scientific and practical aspects be taken into account when setting international rules for animal welfare. Farmers also stress the need to combine scientific data with their practical experience. Raising awareness, adopting a risk-based approach, education, labelling, slaughterhouse capacity and animal health, as well as standards and rules, are issues of importance for developing a long distance transportation infrastructure respectful of animal welfare around the world.
International Federation of Agricultural Producers/LTO Netherland, Drachten, The Netherlands. klaasjohan@yahoo.com
Osinga
Klaas Johan
KJ
eng
Journal Article
Italy
Vet Ital
0201543
0505-401X
IM
21002435
1946
12
01
2010
10
28
0002-9955
132
12
1946
Nov
23
Journal of the American Medical Association
J Am Med Assoc
BRUTALITIES of Nazi physicians.
714
eng
Journal Article
Not Available
J Am Med Assoc
7507176
0002-9955
OM
4611:956w
RESEARCH, MEDICAL/human experimentation
WAR/crimes
21007460
1946
12
01
2010
10
28
1944-1945
The Proceedings of the Cardiff Medical Society
Proc Cardiff Med Soc
Social psychiatry in the post-war world.
55-9
REES
J R
JR
eng
Journal Article
Not Available
Proc Cardiff Med Soc
7505858
OM
4610:216i1
PSYCHIATRY/social
21024418
1946
12
01
2010
11
12
64
1944-1945
Transactions. Ophthalmological Society of the United Kingdom
Trans Opthal Soc U K
Preventable blindness in war.
165-78
CRUISE
R
R
eng
Journal Article
Not Available
Trans Opthal Soc U K
0201270
OM
4610:1030s
BLINDNESS/in war
MILITARY MEDICINE/ophthalmology